Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein is a protein that in humans is encoded by the HERPUD1gene.[1][2][3]
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.[3]
↑Kokame K, Agarwala KL, Kato H, Miyata T (Nov 2000). "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress". J Biol Chem. 275 (42): 32846–53. doi:10.1074/jbc.M002063200. PMID10922362.
↑van Laar T, Schouten T, Hoogervorst E, van Eck M, van der Eb AJ, Terleth C (Apr 2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway". FEBS Lett. 469 (1): 123–31. doi:10.1016/S0014-5793(00)01253-9. PMID10708769.
↑ 4.04.1Kim, Tae-Yeon; Kim Eunmin; Yoon Sungjoo Kim; Yoon Jong-Bok (May 2008). "Herp enhances ER-associated protein degradation by recruiting ubiquilins". Biochem. Biophys. Res. Commun. United States. 369 (2): 741–6. doi:10.1016/j.bbrc.2008.02.086. PMID18307982.
Further reading
van Laar T, van der Eb AJ, Terleth C (2002). "Mif1: a missing link between the unfolded protein response pathway and ER-associated protein degradation?". Curr. Protein Pept. Sci. 2 (2): 169–90. doi:10.2174/1389203013381189. PMID12370023.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID7584026.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID8619474.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Kokame K, Kato H, Miyata T (2001). "Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response". J. Biol. Chem. 276 (12): 9199–205. doi:10.1074/jbc.M010486200. PMID11112790.
Sai X, Kawamura Y, Kokame K, et al. (2002). "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein". J. Biol. Chem. 277 (15): 12915–20. doi:10.1074/jbc.M112372200. PMID11799129.
Sai X, Kokame K, Shiraishi H, et al. (2003). "The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generation". FEBS Lett. 553 (1–2): 151–6. doi:10.1016/S0014-5793(03)01009-3. PMID14550564.
Schulze A, Standera S, Buerger E, et al. (2006). "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway". J. Mol. Biol. 354 (5): 1021–7. doi:10.1016/j.jmb.2005.10.020. PMID16289116.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID16713569.
Lenz B, Bleich S, Beutler S, et al. (2007). "Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites". Exp. Cell Res. 312 (20): 4049–55. doi:10.1016/j.yexcr.2006.09.004. PMID17020760.
