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{{Infobox_gene}}
{{PBB_Controls
'''Ubiquitin-conjugating enzyme E2 E1''' is a [[protein]] that in humans is encoded by the ''UBE2E1'' [[gene]].<ref name="pmid8576257">{{cite journal | vauthors = Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M | title = Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5 | journal = J. Biol. Chem. | volume = 271 | issue = 5 | pages = 2795–800  | date = Mar 1996 | pmid = 8576257 | pmc =  | doi = 10.1074/jbc.271.5.2795 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7324| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_UBE2E1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y6l.
| PDB = {{PDB2|1y6l}}
| Name = Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
| HGNCid = 12477
| Symbol = UBE2E1
| AltSymbols =; UBCH6
| OMIM = 602916
| ECnumber = 
| Homologene = 84372
| MGIid = 107411
| GeneAtlas_image1 = PBB_GE_UBE2E1_212519_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7324
    | Hs_Ensembl = ENSG00000170142
    | Hs_RefseqProtein = NP_003332
    | Hs_RefseqmRNA = NM_003341
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 23822443
    | Hs_GenLoc_end = 23907792
    | Hs_Uniprot = P51965
    | Mm_EntrezGene = 22194
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_975886
    | Mm_RefseqProtein = XP_980980
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)''', also known as '''UBE2E1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7324| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7324| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
UBE2E1 has been shown to [[Protein-protein interaction|interact]] with [[Ataxin 1]]<ref name=pmid18439907>{{cite journal | vauthors = Hong S, Lee S, Cho SG, Kang S | title = UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1 | journal = Biochem. Biophys. Res. Commun. | volume = 371 | issue = 2 | pages = 256–60  | date = Jun 2008 | pmid = 18439907 | doi = 10.1016/j.bbrc.2008.04.066 }}</ref> and [[NEDD4]].<ref name=pmid9990509>{{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes Cells | volume = 3 | issue = 11 | pages = 751–63  | date = Nov 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x }}</ref><ref name=pmid18287095>{{cite journal | vauthors = Malakhova OA, Zhang DE | title = ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response | journal = J. Biol. Chem. | volume = 283 | issue = 14 | pages = 8783–7  | date = Apr 2008 | pmid = 18287095 | pmc = 2276364 | doi = 10.1074/jbc.C800030200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Pickart CM | title = Mechanisms underlying ubiquitination | journal = Annu. Rev. Biochem. | volume = 70 | issue =  | pages = 503–33 | year = 2001 | pmid = 11395416 | doi = 10.1146/annurev.biochem.70.1.503 }}
| citations =
* {{cite journal | vauthors = Chen P, Johnson P, Sommer T, Jentsch S, Hochstrasser M | title = Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor | journal = Cell | volume = 74 | issue = 2 | pages = 357–69 | year = 1993 | pmid = 8393731 | doi = 10.1016/0092-8674(93)90426-Q }}
*{{cite journal | author=Pickart CM |title=Mechanisms underlying ubiquitination. |journal=Annu. Rev. Biochem. |volume=70 |issue=  |pages= 503-33 |year= 2002 |pmid= 11395416 |doi= 10.1146/annurev.biochem.70.1.503 }}
* {{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes Cells | volume = 3 | issue = 11 | pages = 751–63 | year = 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x }}
*{{cite journal | author=Chen P, Johnson P, Sommer T, ''et al.'' |title=Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor. |journal=Cell |volume=74 |issue= 2 |pages= 357-69 |year= 1993 |pmid= 8393731 |doi= }}
* {{cite journal | vauthors = Nyman TA, Matikainen S, Sareneva T, Julkunen I, Kalkkinen N | title = Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes | journal = Eur. J. Biochem. | volume = 267 | issue = 13 | pages = 4011–9 | year = 2000 | pmid = 10866800 | doi = 10.1046/j.1432-1327.2000.01433.x }}
*{{cite journal  | author=Nuber U, Schwarz S, Kaiser P, ''et al.'' |title=Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2795-800 |year= 1996 |pmid= 8576257 |doi=  }}
* {{cite journal | vauthors = Lenk U, Sommer T | title = Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization | journal = J. Biol. Chem. | volume = 275 | issue = 50 | pages = 39403–10 | year = 2000 | pmid = 10991948 | doi = 10.1074/jbc.M006949200 }}
*{{cite journal | author=Anan T, Nagata Y, Koga H, ''et al.'' |title=Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. |journal=Genes Cells |volume=3 |issue= 11 |pages= 751-63 |year= 1999 |pmid= 9990509 |doi= }}
* {{cite journal | vauthors = Pringa E, Martinez-Noel G, Muller U, Harbers K | title = Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19617–23 | year = 2001 | pmid = 11274149 | doi = 10.1074/jbc.M100192200 }}
*{{cite journal | author=Nyman TA, Matikainen S, Sareneva T, ''et al.'' |title=Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes. |journal=Eur. J. Biochem. |volume=267 |issue= 13 |pages= 4011-9 |year= 2000 |pmid= 10866800 |doi= }}
* {{cite journal | vauthors = Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y | title = N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8 | journal = Eur. J. Biochem. | volume = 268 | issue = 9 | pages = 2725–32 | year = 2001 | pmid = 11322894 | doi = 10.1046/j.1432-1327.2001.02169.x }}
*{{cite journal | author=Lenk U, Sommer T |title=Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39403-10 |year= 2001 |pmid= 10991948 |doi= 10.1074/jbc.M006949200 }}
* {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | year = 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
*{{cite journal | author=Pringa E, Martinez-Noel G, Muller U, Harbers K |title=Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19617-23 |year= 2001 |pmid= 11274149 |doi= 10.1074/jbc.M100192200 }}
* {{cite journal | vauthors = Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H | title = Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme | journal = J. Biochem. | volume = 138 | issue = 6 | pages = 711–9 | year = 2005 | pmid = 16428300 | doi = 10.1093/jb/mvi172 }}
*{{cite journal | author=Ito K, Adachi S, Iwakami R, ''et al.'' |title=N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. |journal=Eur. J. Biochem. |volume=268 |issue= 9 |pages= 2725-32 |year= 2001 |pmid= 11322894 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Takeuchi T, Iwahara S, Saeki Y, ''et al.'' |title=Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. |journal=J. Biochem. |volume=138 |issue= 6 |pages= 711-9 |year= |pmid= 16428300 |doi= 10.1093/jb/mvi172 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Latest revision as of 03:19, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[1][2]

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]

Interactions

UBE2E1 has been shown to interact with Ataxin 1[3] and NEDD4.[4][5]

References

  1. ↑ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257.
  2. ↑ 2.0 2.1 "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".
  3. ↑ Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907.
  4. ↑ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509.
  5. ↑ Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi:10.1074/jbc.C800030200. PMC 2276364. PMID 18287095.

Further reading

  • Pickart CM (2001). "Mechanisms underlying ubiquitination". Annu. Rev. Biochem. 70: 503–33. doi:10.1146/annurev.biochem.70.1.503. PMID 11395416.
  • Chen P, Johnson P, Sommer T, Jentsch S, Hochstrasser M (1993). "Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor". Cell. 74 (2): 357–69. doi:10.1016/0092-8674(93)90426-Q. PMID 8393731.
  • Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509.
  • Nyman TA, Matikainen S, Sareneva T, Julkunen I, Kalkkinen N (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi:10.1046/j.1432-1327.2000.01433.x. PMID 10866800.
  • Lenk U, Sommer T (2000). "Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization". J. Biol. Chem. 275 (50): 39403–10. doi:10.1074/jbc.M006949200. PMID 10991948.
  • Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149.
  • Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894.
  • Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H (2005). "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.


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