Tyrocidine

WikiDoc Resources for Tyrocidine
Articles
Most recent articles on Tyrocidine Most cited articles on Tyrocidine Review articles on Tyrocidine Articles on Tyrocidine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Tyrocidine Images of Tyrocidine Photos of Tyrocidine Podcasts & MP3s on Tyrocidine Videos on Tyrocidine
Evidence Based Medicine
Cochrane Collaboration on Tyrocidine Bandolier on Tyrocidine TRIP on Tyrocidine
Clinical Trials
Ongoing Trials on Tyrocidine at Clinical Trials.gov Trial results on Tyrocidine Clinical Trials on Tyrocidine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Tyrocidine NICE Guidance on Tyrocidine NHS PRODIGY Guidance FDA on Tyrocidine CDC on Tyrocidine
Books
Books on Tyrocidine
News
Tyrocidine in the news Be alerted to news on Tyrocidine News trends on Tyrocidine
Commentary
Blogs on Tyrocidine
Definitions
Definitions of Tyrocidine
Patient Resources / Community
Patient resources on Tyrocidine Discussion groups on Tyrocidine Patient Handouts on Tyrocidine Directions to Hospitals Treating Tyrocidine Risk calculators and risk factors for Tyrocidine
Healthcare Provider Resources
Symptoms of Tyrocidine Causes & Risk Factors for Tyrocidine Diagnostic studies for Tyrocidine Treatment of Tyrocidine
Continuing Medical Education (CME)
CME Programs on Tyrocidine
International
Tyrocidine en Espanol Tyrocidine en Francais
Business
Tyrocidine in the Marketplace Patents on Tyrocidine
Experimental / Informatics
List of terms related to Tyrocidine

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Tyrocidine is a class of naturally occurring antibiotics produced by some strains of Bacillus brevis.

Tyrocidines A, B, and C are cyclic decapeptides. The biosynthesis of tyrocidine involves three enzymes. Parts of its sequence are identical to gramicidin S.

Tyrocidine A: D-Phe L-Pro L-Phe D-Phe L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu 
Tyrocidine B: D-Phe L-Pro L-Trp D-Phe L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu 
Tyrocidine C: D-Phe L-Pro L-Trp D-Trp L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu 
Tyrocidine D: D-Phe L-Pro L-Trp D-Trp L-Asn L-Gln L-Trp L-Val L-Orn L-Leu 

Tyrocidine and gramicidin are the constituents of tyrothricin, which was originally isolated by René Dubos in 1939, and was the first commercially produced antibiotic. It is used as a topical application; toxicity prevents systemic use. Dubos's discovery helped revive interest in research on penicillin.

Tyrocidine kills bacteria by interacting with their cytoplasmic membrane and causing leakage of their intracellular content. It also affects intracellular membranes such as those of mitochondria.

External links

• Tyrocidine at the US National Library of Medicine Medical Subject Headings (MeSH)