Tyrocidine
|
WikiDoc Resources for Tyrocidine |
|
Articles |
|---|
|
Most recent articles on Tyrocidine |
|
Media |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Tyrocidine at Clinical Trials.gov Clinical Trials on Tyrocidine at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Tyrocidine
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Tyrocidine Discussion groups on Tyrocidine Patient Handouts on Tyrocidine Directions to Hospitals Treating Tyrocidine Risk calculators and risk factors for Tyrocidine
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Tyrocidine |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Tyrocidine is a class of naturally occurring antibiotics produced by some strains of Bacillus brevis.
Tyrocidines A, B, and C are cyclic decapeptides. The biosynthesis of tyrocidine involves three enzymes. Parts of its sequence are identical to gramicidin S.
Tyrocidine A: D-Phe L-Pro L-Phe D-Phe L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu Tyrocidine B: D-Phe L-Pro L-Trp D-Phe L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu Tyrocidine C: D-Phe L-Pro L-Trp D-Trp L-Asn L-Gln L-Tyr L-Val L-Orn L-Leu Tyrocidine D: D-Phe L-Pro L-Trp D-Trp L-Asn L-Gln L-Trp L-Val L-Orn L-Leu
Tyrocidine and gramicidin are the constituents of tyrothricin, which was originally isolated by René Dubos in 1939, and was the first commercially produced antibiotic. It is used as a topical application; toxicity prevents systemic use. Dubos's discovery helped revive interest in research on penicillin.
Tyrocidine kills bacteria by interacting with their cytoplasmic membrane and causing leakage of their intracellular content. It also affects intracellular membranes such as those of mitochondria.
External links
- Tyrocidine at the US National Library of Medicine Medical Subject Headings (MeSH)