Tumor lysis syndrome natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
If left untreated, patients with tumor lysis syndrome may progress to develop [[nausea]], [[vomiting]], [[diarrhea]], [[anorexia]], [[hematuria]], [[heart palpitations]], and [[muscle cramps]]. Eventually, tumor lysis syndrome may lead to death.<ref name="pmid18509186">{{cite journal| author=Coiffier B, Altman A, Pui CH, Younes A, Cairo MS| title=Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. | journal=J Clin Oncol | year= 2008 | volume= 26 | issue= 16 | pages= 2767-78 | pmid=18509186 | doi=10.1200/JCO.2007.15.0177 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18509186 }} </ref> <ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | |||
If left untreated, patients with tumor lysis syndrome may progress to develop [[nausea]], [[vomiting]], [[diarrhea]], [[anorexia]], [[hematuria]], [[heart palpitations]], [[muscle cramps]].<ref name="pmid18509186">{{cite journal| author=Coiffier B, Altman A, Pui CH, Younes A, Cairo MS| title=Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. | journal=J Clin Oncol | year= 2008 | volume= 26 | issue= 16 | pages= 2767-78 | pmid=18509186 | doi=10.1200/JCO.2007.15.0177 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18509186 }} </ref> <ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | |||
==Complications== | ==Complications== |
Revision as of 20:47, 18 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
If left untreated, patients with tumor lysis syndrome may progress to develop nausea, vomiting, diarrhea, anorexia, hematuria, heart palpitations, muscle cramps. Common complications of tumor lysis syndrome include hyperkalemia, hypocalcemia, and hyperphosphatemia. Prognosis is generally good, if not associated with acute renal failure.[1]
Natural History
If left untreated, patients with tumor lysis syndrome may progress to develop nausea, vomiting, diarrhea, anorexia, hematuria, heart palpitations, and muscle cramps. Eventually, tumor lysis syndrome may lead to death.[1] [2]
Complications
- Life-threatening conditions may result in death or permanent disability within 24 hours if left untreated.[1]
- Hyperkalemia
- Hyperphosphatemia
- Hyperuricemia
- Hypocalcemia
- Acute kidney injury
- Arrhythmia
- Seizures
- Tetany
References
- ↑ 1.0 1.1 1.2 Coiffier B, Altman A, Pui CH, Younes A, Cairo MS (2008). "Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review". J Clin Oncol. 26 (16): 2767–78. doi:10.1200/JCO.2007.15.0177. PMID 18509186.
- ↑ Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.