Tricuspid stenosis medical therapy: Difference between revisions

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__NOTOC__
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{{Tricuspid stenosis}}
{{Tricuspid stenosis}}
{{CMG}}; {{AE}} {{Rim}} {{VKG}}
{{CMG}}; {{AE}} {{VKG}} ;[[User:Mohammed Salih|Mohammed Salih, M.D.]] ;{{Rim}}  


==Overview==
==Overview==
Medical therapy with [[diuretics]] and sodium restriction is the mainstay of treatment among patients with tricuspid stenosis complicated by systemic and pulmonary congestion. Patients with tricuspid stenosis should receive medical therapy for [[left heart failure]], and/or [[pulmonary hypertension]] in case they are present.
Medical therapy with [[diuretics]] and [[sodium]] restriction is the mainstay of treatment among patients with [[tricuspid stenosis]] complicated by [[systemic]] and [[pulmonary congestion]]. Patients with [[tricuspid stenosis]] should receive medical therapy for [[left heart failure]], and/or [[pulmonary hypertension]] in case they are present.
==Medical Therapy==
==Medical Therapy==


*Pharmacologic medical therapies for tricuspid stenosis include diuretic therapy.<ref name="pmid24589852">{{cite journal| author=Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA et al.| title=2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=Circulation | year= 2014 | volume=  | issue=  | pages=  | pmid=24589852 | doi=10.1161/CIR.0000000000000029 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24589852  }} </ref>
*Pharmacologic medical therapies for [[tricuspid stenosis]] include [[diuretic]] therapy.<ref name="pmid24589852">{{cite journal| author=Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA et al.| title=2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=Circulation | year= 2014 | volume=  | issue=  | pages=  | pmid=24589852 | doi=10.1161/CIR.0000000000000029 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24589852  }} </ref>
*Loop diuretics may be helpful in relieving some of the symptoms which include:<ref name="pmid24603191">{{cite journal| author=Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA | display-authors=etal| title=2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=J Am Coll Cardiol | year= 2014 | volume= 63 | issue= 22 | pages= e57-185 | pmid=24603191 | doi=10.1016/j.jacc.2014.02.536 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24603191  }}</ref><ref name="VahanianAlfieri2012">{{cite journal|last1=Vahanian|first1=Alec|last2=Alfieri|first2=Ottavio|last3=Andreotti|first3=Felicita|last4=Antunes|first4=Manuel J.|last5=Barón-Esquivias|first5=Gonzalo|last6=Baumgartner|first6=Helmut|last7=Borger|first7=Michael Andrew|last8=Carrel|first8=Thierry P.|last9=De Bonis|first9=Michele|last10=Evangelista|first10=Arturo|last11=Falk|first11=Volkmar|last12=Iung|first12=Bernard|last13=Lancellotti|first13=Patrizio|last14=Pierard|first14=Luc|last15=Price|first15=Susanna|last16=Schäfers|first16=Hans-Joachim|last17=Schuler|first17=Gerhard|last18=Stepinska|first18=Janina|last19=Swedberg|first19=Karl|last20=Takkenberg|first20=Johanna|last21=Von Oppell|first21=Ulrich Otto|last22=Windecker|first22=Stephan|last23=Zamorano|first23=Jose Luis|last24=Zembala|first24=Marian|last25=Bax|first25=Jeroen J.|last26=Baumgartner|first26=Helmut|last27=Ceconi|first27=Claudio|last28=Dean|first28=Veronica|last29=Deaton|first29=Christi|last30=Fagard|first30=Robert|last31=Funck-Brentano|first31=Christian|last32=Hasdai|first32=David|last33=Hoes|first33=Arno|last34=Kirchhof|first34=Paulus|last35=Knuuti|first35=Juhani|last36=Kolh|first36=Philippe|last37=McDonagh|first37=Theresa|last38=Moulin|first38=Cyril|last39=Popescu|first39=Bogdan A.|last40=Reiner|first40=Željko|last41=Sechtem|first41=Udo|last42=Sirnes|first42=Per Anton|last43=Tendera|first43=Michal|last44=Torbicki|first44=Adam|last45=Vahanian|first45=Alec|last46=Windecker|first46=Stephan|last47=Popescu|first47=Bogdan A.|last48=Von Segesser|first48=Ludwig|last49=Badano|first49=Luigi P.|last50=Bunc|first50=Matjaž|last51=Claeys|first51=Marc J.|last52=Drinkovic|first52=Niksa|last53=Filippatos|first53=Gerasimos|last54=Habib|first54=Gilbert|last55=Kappetein|first55=A. Pieter|last56=Kassab|first56=Roland|last57=Lip|first57=Gregory Y.H.|last58=Moat|first58=Neil|last59=Nickenig|first59=Georg|last60=Otto|first60=Catherine M.|last61=Pepper|first61=John|last62=Piazza|first62=Nicolo|last63=Pieper|first63=Petronella G.|last64=Rosenhek|first64=Raphael|last65=Shuka|first65=Naltin|last66=Schwammenthal|first66=Ehud|last67=Schwitter|first67=Juerg|last68=Mas|first68=Pilar Tornos|last69=Trindade|first69=Pedro T.|last70=Walther|first70=Thomas|title=Guidelines on the management of valvular heart disease (version 2012)|journal=European Heart Journal|volume=33|issue=19|year=2012|pages=2451–2496|issn=1522-9645|doi=10.1093/eurheartj/ehs109}}</ref>
*[[Loop diuretics]] may be helpful in relieving some of the [[Symptom|symptoms]] which include:<ref name="pmid24603191">{{cite journal| author=Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA | display-authors=etal| title=2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=J Am Coll Cardiol | year= 2014 | volume= 63 | issue= 22 | pages= e57-185 | pmid=24603191 | doi=10.1016/j.jacc.2014.02.536 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24603191  }}</ref><ref name="VahanianAlfieri2012">{{cite journal|last1=Vahanian|first1=Alec|last2=Alfieri|first2=Ottavio|last3=Andreotti|first3=Felicita|last4=Antunes|first4=Manuel J.|last5=Barón-Esquivias|first5=Gonzalo|last6=Baumgartner|first6=Helmut|last7=Borger|first7=Michael Andrew|last8=Carrel|first8=Thierry P.|last9=De Bonis|first9=Michele|last10=Evangelista|first10=Arturo|last11=Falk|first11=Volkmar|last12=Iung|first12=Bernard|last13=Lancellotti|first13=Patrizio|last14=Pierard|first14=Luc|last15=Price|first15=Susanna|last16=Schäfers|first16=Hans-Joachim|last17=Schuler|first17=Gerhard|last18=Stepinska|first18=Janina|last19=Swedberg|first19=Karl|last20=Takkenberg|first20=Johanna|last21=Von Oppell|first21=Ulrich Otto|last22=Windecker|first22=Stephan|last23=Zamorano|first23=Jose Luis|last24=Zembala|first24=Marian|last25=Bax|first25=Jeroen J.|last26=Baumgartner|first26=Helmut|last27=Ceconi|first27=Claudio|last28=Dean|first28=Veronica|last29=Deaton|first29=Christi|last30=Fagard|first30=Robert|last31=Funck-Brentano|first31=Christian|last32=Hasdai|first32=David|last33=Hoes|first33=Arno|last34=Kirchhof|first34=Paulus|last35=Knuuti|first35=Juhani|last36=Kolh|first36=Philippe|last37=McDonagh|first37=Theresa|last38=Moulin|first38=Cyril|last39=Popescu|first39=Bogdan A.|last40=Reiner|first40=Željko|last41=Sechtem|first41=Udo|last42=Sirnes|first42=Per Anton|last43=Tendera|first43=Michal|last44=Torbicki|first44=Adam|last45=Vahanian|first45=Alec|last46=Windecker|first46=Stephan|last47=Popescu|first47=Bogdan A.|last48=Von Segesser|first48=Ludwig|last49=Badano|first49=Luigi P.|last50=Bunc|first50=Matjaž|last51=Claeys|first51=Marc J.|last52=Drinkovic|first52=Niksa|last53=Filippatos|first53=Gerasimos|last54=Habib|first54=Gilbert|last55=Kappetein|first55=A. Pieter|last56=Kassab|first56=Roland|last57=Lip|first57=Gregory Y.H.|last58=Moat|first58=Neil|last59=Nickenig|first59=Georg|last60=Otto|first60=Catherine M.|last61=Pepper|first61=John|last62=Piazza|first62=Nicolo|last63=Pieper|first63=Petronella G.|last64=Rosenhek|first64=Raphael|last65=Shuka|first65=Naltin|last66=Schwammenthal|first66=Ehud|last67=Schwitter|first67=Juerg|last68=Mas|first68=Pilar Tornos|last69=Trindade|first69=Pedro T.|last70=Walther|first70=Thomas|title=Guidelines on the management of valvular heart disease (version 2012)|journal=European Heart Journal|volume=33|issue=19|year=2012|pages=2451–2496|issn=1522-9645|doi=10.1093/eurheartj/ehs109}}</ref>
**Hepatic congestion
**[[Hepatic]] [[congestion]]
**Decreases the preload
**Decreases the [[Preload (cardiology)|preload]]
**Systemic venous hypertension
**Systemic [[venous]] [[hypertension]]
**Lower extremity edema
**Lower extremity [[edema]]
*Due to the risk of worsening low-flow syndrome diuretics may be used with caution in patients with tricuspid stenosis.
*Due to the risk of worsening low-flow syndrome [[diuretics]] may be used with caution in patients with [[tricuspid stenosis]].
*Medical interventions were also indicated with patients who are having atrial fibrillation in the settings of tricuspid stenosis which include the following:  
*Medical interventions were also indicated with patients who are having [[atrial fibrillation]] in the settings of tricuspid stenosis which include the following:
 
== 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines<ref name="pmid33332150">{{cite journal| author=Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, Gentile F | display-authors=etal| title=2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. | journal=Circulation | year= 2021 | volume= 143 | issue= 5 | pages= e72-e227 | pmid=33332150 | doi=10.1161/CIR.0000000000000923 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33332150  }}</ref> ==
{| class="wikitable" style="width: 80%;"
|-
| colspan="1" style="text-align:center; background:LemonChiffon" |[[ACC AHA guidelines classification scheme#Classification of Recommendations|Class IIa]]
|-
| bgcolor="LemonChiffon" |1.   In patients with signs and symptoms of right-sided HF attributable to severe TR (Stages C and D), diuretics can be useful. ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C-EO]])'' <nowiki>"</nowiki>
2.   In patients with signs and symptoms of right-sided HF attributable to severe secondary TR (Stages C and D), therapies to treat the primary cause of HF (eg, pulmonary vasodilators to reduce elevated pulmonary artery pressures, GDMT for HF with reduced LVEF, or rhythm control of AF) can be useful. ''([[ACC AHA guidelines classification scheme#Level of Evidence|Level of Evidence: C-EO]])''
|}
 
=====Pharmacological Cardioversion=====
=====Pharmacological Cardioversion=====


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|}
|}


* Medical interventions were also indicated with patients who are having systemic rheumatic diseases and endocarditis as the cause of tricuspid stenosis.
* Medical interventions were also indicated with patients who are having systemic [[Rheumatism|rheumatic diseases]] and [[endocarditis]] as the cause of tricuspid stenosis.
*Treating the patients who are having systemic lupus erythematosus (SLE) and antiphospholipid antibodies (APLA) may reduce the coating over the infected valves and chordae and in turn reduces the stenosis and regurgitation.<ref name="pmid28706863">{{cite journal| author=Adler DS| title=Non-functional tricuspid valve disease. | journal=Ann Cardiothorac Surg | year= 2017 | volume= 6 | issue= 3 | pages= 204-213 | pmid=28706863 | doi=10.21037/acs.2017.04.04 | pmc=5494423 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28706863  }}</ref><ref name="pmid18222317">{{cite journal| author=Shah PM, Raney AA| title=Tricuspid valve disease. | journal=Curr Probl Cardiol | year= 2008 | volume= 33 | issue= 2 | pages= 47-84 | pmid=18222317 | doi=10.1016/j.cpcardiol.2007.10.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18222317  }}</ref>
*<nowiki/>Treating the patients who are having [[systemic lupus erythematosus]] ([[SLE]]) and [[antiphospholipid antibodies]] (APLA) may reduce the coating over the infected valves and chordae and in turn reduces the [[stenosis]] and [[regurgitation]].<ref name="pmid28706863">{{cite journal| author=Adler DS| title=Non-functional tricuspid valve disease. | journal=Ann Cardiothorac Surg | year= 2017 | volume= 6 | issue= 3 | pages= 204-213 | pmid=28706863 | doi=10.21037/acs.2017.04.04 | pmc=5494423 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28706863  }}</ref><ref name="pmid18222317">{{cite journal| author=Shah PM, Raney AA| title=Tricuspid valve disease. | journal=Curr Probl Cardiol | year= 2008 | volume= 33 | issue= 2 | pages= 47-84 | pmid=18222317 | doi=10.1016/j.cpcardiol.2007.10.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18222317  }}</ref>
 
===Disease Name===


* '''1 Stage 1 - Name of stage'''
== References ==
** 1.1 '''Specific Organ system involved 1'''
*** 1.1.1 '''Adult'''
**** Preferred regimen (1): [[drug name]] 100 mg PO q12h for 10-21 days '''(Contraindications/specific instructions)''' 
**** Preferred regimen (2): [[drug name]] 500 mg PO q8h for 14-21 days
**** Preferred regimen (3): [[drug name]] 500 mg q12h for 14-21 days
**** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days 
**** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
**** Alternative regimen (3): [[drug name]] 500 mg PO q6h for 14–21 days
*** 1.1.2 '''Pediatric'''
**** 1.1.2.1 (Specific population e.g. '''children < 8 years of age''')
***** Preferred regimen (1): [[drug name]] 50 mg/kg PO per day q8h (maximum, 500 mg per dose) 
***** Preferred regimen (2): [[drug name]] 30 mg/kg PO per day in 2 divided doses (maximum, 500 mg per dose)
***** Alternative regimen (1): [[drug name]]10 mg/kg PO q6h (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h (maximum, 500 mg per dose)
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
****1.1.2.2 (Specific population e.g. '<nowiki/>'''''children < 8 years of age'''''')
***** Preferred regimen (1): [[drug name]] 4 mg/kg/day PO q12h(maximum, 100 mg per dose)
***** Alternative regimen (1): [[drug name]] 10 mg/kg PO q6h (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h (maximum, 500 mg per dose) 
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h (maximum, 500 mg per dose)
** 1.2 '''Specific Organ system involved 2'''
*** 1.2.1 '''Adult'''
**** Preferred regimen (1): [[drug name]] 500 mg PO q8h
*** 1.2.2  '''Pediatric'''
**** Preferred regimen (1): [[drug name]] 50 mg/kg/day PO q8h (maximum, 500 mg per dose)


* 2 '''Stage 2 - Name of stage'''
** 2.1 '''Specific Organ system involved 1 '''
**: '''Note (1):'''
**: '''Note (2)''':
**: '''Note (3):'''
*** 2.1.1 '''Adult'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 2 g IV q24h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 2 g IV q8h for 14 (14–21) days
***** Alternative regimen (2): [[drug name]] 18–24 MU/day IV q4h for 14 (14–21) days
**** Oral regimen
***** Preferred regimen (1): [[drug name]] 500 mg PO q8h for 14 (14–21) days
***** Preferred regimen (2): [[drug name]] 100 mg PO q12h for 14 (14–21) days
***** Preferred regimen (3): [[drug name]] 500 mg PO q12h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days 
***** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
***** Alternative regimen (3):[[drug name]] 500 mg PO q6h for 14–21 days
*** 2.1.2 '''Pediatric'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
***** Alternative regimen (1): [[drug name]] 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
***** Alternative regimen (2):  [[drug name]] 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day) '<nowiki/>'''''(Contraindications/specific instructions)''''''
**** Oral regimen
***** Preferred regimen (1):  [[drug name]] 50 mg/kg/day PO q8h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Preferred regimen (2): [[drug name]] '''(for children aged ≥ 8 years)''' 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
***** Preferred regimen (3): [[drug name]] 30 mg/kg/day PO q12h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Alternative regimen (1):  [[drug name]] 10 mg/kg PO q6h 7–10 days  (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h for 14–21 days  (maximum, 500 mg per dose)
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h for 14–21 days  (maximum,500 mg per dose)
** 2.2  '<nowiki/>'''''Other Organ system involved 2''''''
**: '''Note (1):'''
**: '''Note (2)''':
**: '''Note (3):'''
*** 2.2.1 '''Adult'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 2 g IV q24h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 2 g IV q8h for 14 (14–21) days
***** Alternative regimen (2): [[drug name]] 18–24 MU/day IV q4h for 14 (14–21) days
**** Oral regimen
***** Preferred regimen (1): [[drug name]] 500 mg PO q8h for 14 (14–21) days
***** Preferred regimen (2): [[drug name]] 100 mg PO q12h for 14 (14–21) days
***** Preferred regimen (3): [[drug name]] 500 mg PO q12h for 14 (14–21) days
***** Alternative regimen (1): [[drug name]] 500 mg PO q6h for 7–10 days 
***** Alternative regimen (2): [[drug name]] 500 mg PO q12h for 14–21 days
***** Alternative regimen (3):[[drug name]] 500 mg PO q6h for 14–21 days
*** 2.2.2 '''Pediatric'''
**** Parenteral regimen
***** Preferred regimen (1): [[drug name]] 50–75 mg/kg IV q24h for 14 (14–21) days (maximum, 2 g)
***** Alternative regimen (1): [[drug name]] 150–200 mg/kg/day IV q6–8h for 14 (14–21) days (maximum, 6 g per day)
***** Alternative regimen (2):  [[drug name]] 200,000–400,000 U/kg/day IV q4h for 14 (14–21) days (maximum, 18–24 million U per day)
**** Oral regimen
***** Preferred regimen (1):  [[drug name]] 50 mg/kg/day PO q8h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Preferred regimen (2): [[drug name]] 4 mg/kg/day PO q12h for 14 (14–21) days (maximum, 100 mg per dose)
***** Preferred regimen (3): [[drug name]] 30 mg/kg/day PO q12h for 14 (14–21) days  (maximum, 500 mg per dose)
***** Alternative regimen (1):  [[drug name]] 10 mg/kg PO q6h 7–10 days  (maximum, 500 mg per day)
***** Alternative regimen (2): [[drug name]] 7.5 mg/kg PO q12h for 14–21 days  (maximum, 500 mg per dose)
***** Alternative regimen (3): [[drug name]] 12.5 mg/kg PO q6h for 14–21 days  (maximum,500 mg per dose)


==References==
*
{{Reflist|2}}
{{Reflist|2}}



Latest revision as of 14:13, 8 December 2022

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2] ;Mohammed Salih, M.D. ;Rim Halaby, M.D. [3]

Overview

Medical therapy with diuretics and sodium restriction is the mainstay of treatment among patients with tricuspid stenosis complicated by systemic and pulmonary congestion. Patients with tricuspid stenosis should receive medical therapy for left heart failure, and/or pulmonary hypertension in case they are present.

Medical Therapy

2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines[4]

Class IIa
1.   In patients with signs and symptoms of right-sided HF attributable to severe TR (Stages C and D), diuretics can be useful. (Level of Evidence: C-EO) "

2.   In patients with signs and symptoms of right-sided HF attributable to severe secondary TR (Stages C and D), therapies to treat the primary cause of HF (eg, pulmonary vasodilators to reduce elevated pulmonary artery pressures, GDMT for HF with reduced LVEF, or rhythm control of AF) can be useful. (Level of Evidence: C-EO)

Pharmacological Cardioversion
Class I
"1. Flecainide, dofetilide, propafenone, and intravenous ibutilide are useful for pharmacological cardioversion of AF or atrial flutter provided contraindications to the selected drug are absent. (Level of Evidence: A) "
Class III: Harm
"1. Dofetilide therapy should not be initiated out of hospital owing to the risk of excessive QT prolongation that can cause torsades de pointes. (Level of Evidence: B) "
Class IIa
"1. Administration of oral amiodarone is a reasonable option for pharmacological cardioversion of AF. (Level of Evidence: A) "
"2. Propafenone or flecainide (“pill-in-the-pocket”) in addition to a beta blocker or nondihydropyridine calcium channel antagonist is reasonable to terminate AF outside the hospital once this treatment has been observed to be safe in a monitored setting for selected patients. (Level of Evidence: B) "

References

  1. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA; et al. (2014). "2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". Circulation. doi:10.1161/CIR.0000000000000029. PMID 24589852.
  2. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA; et al. (2014). "2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". J Am Coll Cardiol. 63 (22): e57–185. doi:10.1016/j.jacc.2014.02.536. PMID 24603191.
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