Triclosan
{{DrugProjectFormSinglePage |authorTag=Ammu Susheela, M.D. [1] |OTC=Yes |genericName=triclosan |aOrAn=an |drugClass=antiseptic |indicationType=treatment |indication=for hand washing to decrease bacteria on skin |adverseReactions=hypersensitivity |blackBoxWarningTitle=ConditionName: |blackBoxWarningBody=ConditionName:
|fdaLIADAdult=* For hand washing to decrease bacteria on skin
- Recommended for repeated use
|offLabelAdultGuideSupport=There is limited information regarding Off-Label Guideline-Supported Use of Triclosan in adult patients.
|offLabelAdultNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Triclosan in adult patients.
|fdaLIADPed=* For hand washing to decrease bacteria on skin
- Recommended for repeated use
|offLabelPedGuideSupport=There is limited information regarding Off-Label Guideline-Supported Use of Triclosan in pediatric patients.
|offLabelPedNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Triclosan in pediatric patients.
|warnings=* For external use only.
- When using this product avoid contact with eyes. In case of eye contact, flush eyes with water.
- Stop use and ask a doctor if irritation or redness develops, or if condition persists for more than 72 hours.
- Keep out of reach of children.
- If swallowed, get medical help or contact a Poison Control Center right away.
|clinicalTrials=There is limited information regarding Clinical Trial Experience of Triclosan in the drug label. |postmarketing=There is limited information regarding Postmarketing Experience of Triclosan in the drug label.
|drugInteractions= |useInPregnancyFDA=* Pregnancy Category |useInPregnancyAUS=* Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Triclosan in women who are pregnant. |useInLaborDelivery=There is no FDA guidance on use of Triclosan during labor and delivery. |useInNursing=There is no FDA guidance on the use of Triclosan with respect to nursing mothers. |useInPed=There is no FDA guidance on the use of Triclosan with respect to pediatric patients. |useInGeri=There is no FDA guidance on the use of Triclosan with respect to geriatric patients. |useInGender=There is no FDA guidance on the use of Triclosan with respect to specific gender populations. |useInRace=There is no FDA guidance on the use of Triclosan with respect to specific racial populations. |useInRenalImpair=There is no FDA guidance on the use of Triclosan in patients with renal impairment. |useInHepaticImpair=There is no FDA guidance on the use of Triclosan in patients with hepatic impairment. |useInReproPotential=There is no FDA guidance on the use of Triclosan in women of reproductive potentials and males. |useInImmunocomp=There is no FDA guidance one the use of Triclosan in patients who are immunocompromised.
|administration=* Topical |monitoring=There is limited information regarding Monitoring of Triclosan in the drug label. |IVCompat=There is limited information regarding IV Compatibility of Triclosan in the drug label.
|overdose=There is limited information regarding Chronic Overdose of Triclosan in the drug label.
|drugBox=
| Template:Chembox header2 | Triclosan | |
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3D model (JSmol)
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| ECHA InfoCard | Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). |
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| Properties | |
| C12H7Cl3O2 | |
| Molar mass | 289.54 g·mol−1 |
| Hazards | |
| Template:Chembox header2 | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
|mechAction=* At high concentrations, triclosan acts as a biocide with multiple cytoplasmic and membrane targets.[1] However, at the lower concentrations seen in commercial products, triclosan appears bacteriostatic, and it targets bacteria primarily by inhibiting fatty acid synthesis.
- Triclosan binds to bacterial enoyl-acyl carrier protein reductase (ENR) enzyme, which is encoded by the gene FabI. This binding increases the enzyme's affinity for nicotinamide adenine dinucleotide (NAD+). This results in the formation of a stable, ternary complex of ENR-NAD+-triclosan, which is unable to participate in fatty acid synthesis. Fatty acids are necessary for building and reproducing cell membranes. Humans do not have an ENR enzyme and thus are not affected.
|PD=There is limited information regarding Pharmacodynamics of Triclosan in the drug label.
|PK=There is limited information regarding Pharmacokinetics of Triclosan in the drug label.
|nonClinToxic=There is limited information regarding Nonclinical Toxicology of Triclosan in the drug label.
|clinicalStudies=There is limited information regarding Clinical Studies of Triclosan in the drug label.
|packLabel=[[File:Triclosan 01.jpg|thumb|none|400px|This image is provided by the National Library of Medicine.] [[File:Triclosan 02.png|thumb|none|400px|This image is provided by the National Library of Medicine.] |fdaPatientInfo=There is limited information regarding Patient Counseling Information of Triclosan in the drug label.
|alcohol=* Alcohol-Triclosan interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
|brandNames=* ANTIBACTERIAL SPRAY®[2]
|lookAlike= |drugShortage= }} {{#subobject:
|Label Page=Triclosan |Label Name=Triclosan 01.jpg
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{{#subobject:
|Label Page=Triclosan |Label Name=Triclosan 02.png
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- ↑ Russell AD (2004). "Whither triclosan?". J Antimicrob Chemother. 53 (5): 693–5. doi:10.1093/jac/dkh171. PMID 15073159. Check
|pmid=value (help). - ↑ "ANTIBACTERIAL SPRAY - triclosan liquid".