Transitional cell carcinoma classification: Difference between revisions

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===WHO Classification===
===WHO Classification===
The World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) published a consensus opinion classification system for urothelial (transitional cell) tumors
The World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) published a consensus opinion classification system for urothelial (transitional cell) tumors:<ref name="pmid12461053">{{cite journal| author=Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F| title=Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems. | journal=J Clin Pathol | year= 2002 | volume= 55 | issue= 12 | pages= 900-5 | pmid=12461053 | doi= | pmc=PMC1769816 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12461053  }} </ref>


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{{familytree | | | | | B02 | B02= <div style="float: left; text-align: left; width: 30em; padding:1em;">'''Non-invasive urothelial carcinoma'''<ref name="pmid12461053">{{cite journal| author=Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F| title=Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems. | journal=J Clin Pathol | year= 2002 | volume= 55 | issue= 12 | pages= 900-5 | pmid=12461053 | doi= | pmc=PMC1769816 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12461053  }} </ref>
{{familytree | | | | | B02 | B02= <div style="float: left; text-align: left; width: 30em; padding:1em;">'''Non-invasive urothelial carcinoma'''
:*Urothelial carcinoma in situ  
:*Urothelial carcinoma in situ  
:*High grade papillary urothelial carcinoma  
:*High grade papillary urothelial carcinoma  

Revision as of 15:02, 12 February 2016

Transitional cell carcinoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Classification

Based on the growth pattern, transitional cell tumors may be classified into two subtypes:

Type Description

Papillary urothelial carcinoma

  • Have slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity

Flat urothelial carcinomas

  • Lay flat in the lining of the renal pelvis and ureter
  • They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity

WHO Classification

The World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) published a consensus opinion classification system for urothelial (transitional cell) tumors:[1]

 
 
Transitional cell tumors
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Infiltrating urothelial carcinoma
  • with squamous differentiation
  • with glandular differentiation
  • with trophoblastic differentiation
  • Nested
  • Microcystic
  • Micropapillary
  • Lymphoepithelioma-like
  • Lymphoma-like
  • Plasmacytoid
  • Sarcomatoid
  • Giant cell
  • Undifferentiated
 
 
 
 
 
 
 
 
 
Non-invasive urothelial carcinoma
  • Urothelial carcinoma in situ
  • High grade papillary urothelial carcinoma
  • Low grade papillary urothelial carcinoma
  • Non-invasive papillary urothelial neoplasm of low malignant potential
  • Urothelial papilloma
  • Inverted urothelial papilloma

Grading

According to the WHO grading criteria, there are three grades of transitional cell carcinoma based on the degree of cellular differentiation:[2]

Grade Description

Grade 1

  • Tumors with the least degree of cellular anaplasia compatible with a diagnosis of malignancy

Grade 2

  • Histologic features between grades 1 and 3

Grade 3

  • Tumors with the most severe degrees of cellular anaplasia

References

  1. Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F (2002). "Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems". J Clin Pathol. 55 (12): 900–5. PMC 1769816. PMID 12461053.
  2. Grignon, David J (2009). "The current classification of urothelial neoplasms". Modern Pathology. 22: S60–S69. doi:10.1038/modpathol.2008.235. ISSN 0893-3952.

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