Tongue cancer causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
(→Causes) |
||
| Line 12: | Line 12: | ||
*These point mutations lead to deregulation of [[tumor suppressor genes]] (''[[TP53]]''), which is located on [[chromosome 17]]. | *These point mutations lead to deregulation of [[tumor suppressor genes]] (''[[TP53]]''), which is located on [[chromosome 17]]. | ||
*The other [[oncogenes]] associated with oral [[Squamous cell carcinoma|squamous cell cancers]] of tongue include ''[[c-myc]]'' and ''erb -b1''. | *The other [[oncogenes]] associated with oral [[Squamous cell carcinoma|squamous cell cancers]] of tongue include ''[[c-myc]]'' and ''erb -b1''. | ||
*Tobacco exposure causes progressive sequential histological changes to the oral mucosa. Prolonged period of exposure eventually leads to neoplastic transformation, in particular changes in the expression of ''[[p53]]'' [[mutations]]. | *Tobacco exposure causes progressive sequential histological changes to the oral mucosa. | ||
*Prolonged period of exposure eventually leads to neoplastic transformation, in particular changes in the expression of ''[[p53]]'' [[mutations]]. | |||
==References== | ==References== | ||
Latest revision as of 15:22, 21 December 2017
|
Tongue cancer Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Tongue cancer causes On the Web |
|
American Roentgen Ray Society Images of Tongue cancer causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2] Mohammed Abdelwahed M.D[3]
Overview
Tongue cancer is caused by a point mutation in the tumor suppressor gene (TP53). The other oncogenes associated with oral squamous cell cancers of tongue include c-myc and erb -b1.
Causes
The main cause of tongue cancer is genetic mutations due to precancerous lesions or chronic inflammation as follows:[1]
- The mutations in tumor suppressor genes has been reported in patients with cancers of the oral cavity.
- The most abundant carcinogens in tobacco constitute nitrosamines. Nitrosamines can damage DNA, leading to point mutations.
- These point mutations lead to deregulation of tumor suppressor genes (TP53), which is located on chromosome 17.
- The other oncogenes associated with oral squamous cell cancers of tongue include c-myc and erb -b1.
- Tobacco exposure causes progressive sequential histological changes to the oral mucosa.
- Prolonged period of exposure eventually leads to neoplastic transformation, in particular changes in the expression of p53 mutations.
References
- ↑ Abbas NF, Labib El-Sharkawy S, Abbas EA, Abdel Monem El-Shaer M (2007). "Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103 (3): 385–90. doi:10.1016/j.tripleo.2005.11.008. PMID 17321451.