Thyroid adenoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Classification
Thyroid adenomas are classified into 2 subtype: follicular adenoma and others. Others include papillary adenoma which is very rare. Almost all thyroid adenomas are follicular adenomas.[1] Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.[2] Histopathologically, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types:
| Thyroid adenoma | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Microfollicular adenoma (Fetal adenoma) | Macrofollicular adenoma (Colloid adenoma) | Hürthle cell adenoma (Oxyphil or oncocytic tumor) | Atypical embryonal adenoma | Hyalinizing trabecular adenoma | Papillary adenoma | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Almost all thyroid adenomas are follicular adenomas.[1] Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.[2] Histopathologically, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types:
- Fetal (microfollicular) - these have the potential for microinvasion.[3] These consist of small, closely packed follicles lined with epithelium.[4]
- Colloid (macrofollicular) - these do not have any potential for microinvasion[3]
- Embryonal (atypical) - have the potential for microinvasion.[3]
- Hürthle cell adenoma (oxyphil or oncocytic tumor) - have the potential for microinvasion.[3]
- Hyalinizing trabecular adenoma[5]
Papillary adenomas are very rare.[3]
Reference
- ↑ 1.0 1.1 Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 1117. ISBN 0-7216-0187-1.
- ↑ 2.0 2.1 "Endocrine Pathology". Retrieved 2009-05-08.
- ↑ 3.0 3.1 3.2 3.3 3.4 emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules By Daniel J Kelley and Arlen D Meyers. Updated: Oct 17, 2008
- ↑ TheFreeDictionary > microfollicular adenoma Citing: Dorland's Medical Dictionary for Health Consumers. Copyright 2007
- ↑ Ünlütürk, U; Karaveli, G; Sak, S. D.; Erdoğan, M. F. (2011). "Hyalinizing trabecular tumor in a background of lymphocytic thyroiditis: A challenging neoplasm of the thyroid". Endocrine Practice. 17 (6): e140–3. doi:10.4158/EP11138.CR. PMID 21940281.