Thyroid adenoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Classification

 
 
 
 
 
 
 
 
 
 
 
 
Thyroid adenoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Microfollicular adenoma
 
Macrofollicular adenoma
 
Atypical Embryonal adenoma
 
 
 
 
 
Hürthle cell adenoma
 
Hyalinizing trabecular adenoma
 
Papillary adenoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Almost all thyroid adenomas are follicular adenomas.[1] Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.[2] Histopathologically, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types:

  • Fetal (microfollicular) - these have the potential for microinvasion.[3] These consist of small, closely packed follicles lined with epithelium.[4]
  • Colloid (macrofollicular) - these do not have any potential for microinvasion[3]
  • Embryonal (atypical) - have the potential for microinvasion.[3]
  • Hürthle cell adenoma (oxyphil or oncocytic tumor) - have the potential for microinvasion.[3]
  • Hyalinizing trabecular adenoma[5]

Papillary adenomas are very rare.[3]

Reference

  1. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 1117. ISBN 0-7216-0187-1.
  2. "Endocrine Pathology". Retrieved 2009-05-08.
  3. 3.0 3.1 3.2 3.3 3.4 emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules By Daniel J Kelley and Arlen D Meyers. Updated: Oct 17, 2008
  4. TheFreeDictionary > microfollicular adenoma Citing: Dorland's Medical Dictionary for Health Consumers. Copyright 2007
  5. Ünlütürk, U; Karaveli, G; Sak, S. D.; Erdoğan, M. F. (2011). "Hyalinizing trabecular tumor in a background of lymphocytic thyroiditis: A challenging neoplasm of the thyroid". Endocrine Practice. 17 (6): e140–3. doi:10.4158/EP11138.CR. PMID 21940281.