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==Overview==
==Overview==
==Classification==
==Classification==
Thyroid adenomas are classified into 2 subtype: follicular adenoma and others. Others include papillary adenoma which is very rare. Almost all [[thyroid]] adenomas are follicular adenomas.<ref name="isbn0-7216-0187-1">{{cite book |author=Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=1117 |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref> Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.<ref name="urlEndocrine Pathology">{{cite web |url=http://library.med.utah.edu/WebPath/ENDOHTML/ENDO037.html |title=Endocrine Pathology |format= |work= |accessdate=2009-05-08}}</ref> [[Histopathological]]ly, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types:
* Thyroid adenomas are classified into 2 subtype: follicular adenoma and others.  
* Others include papillary adenoma which is very rare.<ref name=Kelley2008>[http://emedicine.medscape.com/article/850823-overview#aw2aab6b4 emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules] By Daniel J Kelley and Arlen D Meyers. Updated: Oct 17, 2008</ref> Almost all [[thyroid]] adenomas are follicular adenomas.<ref name="isbn0-7216-0187-1">{{cite book |author=Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=1117 |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref>  
* Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.<ref name="urlEndocrine Pathology">{{cite web |url=http://library.med.utah.edu/WebPath/ENDOHTML/ENDO037.html |title=Endocrine Pathology |format= |work= |accessdate=2009-05-08}}</ref>  
* [[Histopathological]]ly, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types depicted in the flowchart.
{{Familytree/start}}
{{Familytree/start}}
{{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01= Thyroid adenoma}}
{{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01= Thyroid adenoma}}
{{Familytree|boxstyle=background: #E0FFFF;| | |,|-|-|-|v|-|-|-|v|-|-|-|^|-|-|-|v|-|-|-|v|-|-|-|.| | | | | | | | | | | | | |}}
{{Familytree|boxstyle=background: #E0FFFF;| | |,|-|-|-|v|-|-|-|v|-|-|-|^|-|-|-|v|-|-|-|.| | | | | | | | | | | | | | | | | |}}
{{Familytree|boxstyle=background: #E0FFFF;| | B01 | | B02 | | B03 | | | | | | B04 | | B05 | | B06 | | | | | | | | | | | | | | | | |B01=Microfollicular adenoma (Fetal adenoma)|B02=Macrofollicular adenoma (Colloid adenoma)|B03=Hürthle cell adenoma (Oxyphil or oncocytic tumor)|B04=Atypical embryonal adenoma|B05=Hyalinizing trabecular adenoma|B06=Papillary adenoma}}
{{Familytree|boxstyle=background: #E0FFFF;| | B01 | | B02 | | B03 | | | | | | B04 | | B05 | | | | | | | | | | | | | | | | | | | |B01=Microfollicular adenoma (Fetal adenoma)|B02=Macrofollicular adenoma (colloid adenoma)|B03=Hürthle cell adenoma (oxyphil or oncocytic tumor)|B04=Atypical embryonal adenoma|B05=Hyalinizing trabecular adenoma}}
{{Familytree/end}}
{{Familytree/end}}
Almost all [[thyroid]] adenomas are follicular adenomas.<ref name="isbn0-7216-0187-1">{{cite book |author=Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=1117 |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref> Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.<ref name="urlEndocrine Pathology">{{cite web |url=http://library.med.utah.edu/WebPath/ENDOHTML/ENDO037.html |title=Endocrine Pathology |format= |work= |accessdate=2009-05-08}}</ref> [[Histopathological]]ly, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types:
* Below is a table with the description of different types of follicular adenoma:<ref name=CDC>{{cite web | title = TB Classification | url = http://www.cdc.gov/tb/publications/slidesets/selfstudymodules/module1/classification.htm }}</ref>
*Fetal (microfollicular) - these have the potential for microinvasion.<ref name=Kelley2008/> These consist of small, closely packed follicles lined with epithelium.<ref>[http://medical-dictionary.thefreedictionary.com/microfollicular+adenoma TheFreeDictionary > microfollicular adenoma] Citing: Dorland's Medical Dictionary for Health Consumers. Copyright 2007</ref>
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
* Colloid (macrofollicular) - these do ''not'' have any potential for microinvasion<ref name=Kelley2008/>
|valign=top|
* Embryonal (atypical) - have the potential for microinvasion.<ref name=Kelley2008/>
|+
* Hürthle cell adenoma (oxyphil or oncocytic tumor) - have the potential for microinvasion.<ref name=Kelley2008/>
! style="background: #4479BA; width: 50px;" | {{fontcolor|#FFF|Number}}
* Hyalinizing trabecular adenoma<ref>{{Cite journal | pmid = 21940281| year = 2011| author1 = Ünlütürk| first1 = U| title = Hyalinizing trabecular tumor in a background of lymphocytic thyroiditis: A challenging neoplasm of the thyroid| journal = Endocrine Practice| volume = 17| issue = 6| pages = e140–3| last2 = Karaveli| first2 = G| last3 = Sak| first3 = S. D.| last4 = Erdoğan| first4 = M. F.| doi = 10.4158/EP11138.CR}}</ref>
! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Type of follicular adenoma}}
! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Description}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
1
| style="padding: 5px 5px; background: #F5F5F5;" |
* Microfollicular adenoma (Fetal)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consist of small, closely packed follicles lined with epithelium
* Have the potential for microinvasion
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
2
| style="padding: 5px 5px; background: #F5F5F5;" |
* Macrofollicular adenoma (colloid adenoma)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of large amount of colloid
* Do not have the potential for microinvasion
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
3
| style="padding: 5px 5px; background: #F5F5F5;" |
* Hürthle cell adenoma (oxyphil or oncocytic tumor)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of oxyphil cells
* Have the potential for microinvasion
|-


Papillary adenomas are very rare.<ref name=Kelley2008>[http://emedicine.medscape.com/article/850823-overview#aw2aab6b4 emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules] By Daniel J Kelley and Arlen D Meyers. Updated: Oct 17, 2008</ref>
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
4
| style="padding: 5px 5px; background: #F5F5F5;" |
* Atypical embryonal adenoma
 
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of embryonic cells
* Have the potential for microinvasion
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
5
| style="padding: 5px 5px; background: #F5F5F5;" |
* Hyalinizing trabecular adenoma
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of hyalinization
* Have the potential for microinvasion
|}
==Reference==
==Reference==
{{Reflist}}
{{Reflist}}

Revision as of 04:49, 12 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Classification

  • Thyroid adenomas are classified into 2 subtype: follicular adenoma and others.
  • Others include papillary adenoma which is very rare.[1] Almost all thyroid adenomas are follicular adenomas.[2]
  • Follicular adenomas can be described as "cold", "warm" or "hot" depending on their level of function.[3]
  • Histopathologically, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types depicted in the flowchart.
 
 
 
 
 
 
 
 
 
 
 
 
Thyroid adenoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Microfollicular adenoma (Fetal adenoma)
 
Macrofollicular adenoma (colloid adenoma)
 
Hürthle cell adenoma (oxyphil or oncocytic tumor)
 
 
 
 
 
Atypical embryonal adenoma
 
Hyalinizing trabecular adenoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • Below is a table with the description of different types of follicular adenoma:[4]
Number Type of follicular adenoma Description

1

  • Microfollicular adenoma (Fetal)
  • Consist of small, closely packed follicles lined with epithelium
  • Have the potential for microinvasion

2

  • Macrofollicular adenoma (colloid adenoma)
  • Consists of large amount of colloid
  • Do not have the potential for microinvasion

3

  • Hürthle cell adenoma (oxyphil or oncocytic tumor)
  • Consists of oxyphil cells
  • Have the potential for microinvasion

4

  • Atypical embryonal adenoma
  • Consists of embryonic cells
  • Have the potential for microinvasion

5

  • Hyalinizing trabecular adenoma
  • Consists of hyalinization
  • Have the potential for microinvasion

Reference

  1. ↑ emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules By Daniel J Kelley and Arlen D Meyers. Updated: Oct 17, 2008
  2. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 1117. ISBN 0-7216-0187-1.
  3. ↑ "Endocrine Pathology". Retrieved 2009-05-08.
  4. ↑ "TB Classification".
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