Thyroid adenoma classification: Difference between revisions

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{{Thyroid adenoma}}
{{Thyroid adenoma}}
{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{RAK}}
==Overview==
==Overview==
Thyroid adenoma may be classified according to the histology into 3 subtypes/groups: follicular adenoma, papillary adenoma, and signet cell adenoma.
Thyroid adenoma may be classified based on [[FNA]] [[cytology]] into 6 groups include macrofollicular, [[Adenomatoid tumor|adenomatoid]], colloid [[adenomas]], [[nodular]] [[goiter]], lymphocytic [[thyroiditis]] and [[granulomatous]] [[thyroiditis]].
 
==Classification==
==Classification==
* Thyroid adenomas are classified into 2 subtype: [[Follicular thyroid adenoma|follicular adenoma]] and others.<ref> Thyroid adenoma. Wikipedia. https://en.wikipedia.org/wiki/Thyroid_adenoma Accessed on October 11, 2015</ref>
*Thyroid adenoma may be classified based on [[Fine needle aspiration]] (FNA) cytology into 6 groups (known as The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC)) :<ref name="pmid198888582">{{cite journal| author=Cibas ES, Ali SZ| title=The Bethesda System for Reporting Thyroid Cytopathology. | journal=Thyroid | year= 2009 | volume= 19 | issue= 11 | pages= 1159-65 | pmid=19888858 | doi=10.1089/thy.2009.0274 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19888858  }}</ref>
* Almost all [[thyroid]] adenomas are follicular adenomas.<ref name="isbn0-7216-0187-1">{{cite book |author=Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=1117 |isbn=0-7216-0187-1 |oclc= |doi= |accessdate=}}</ref> Others include papillary adenoma and signet cell adenoma which are very rare.<ref name=Kelley2008>[http://emedicine.medscape.com/article/850823-overview#aw2aab6b4 emedicine > Thyroid, Evaluation of Solitary Thyroid Nodule > Benign Thyroid Nodules] By Daniel J Kelley and Arlen D Meyers. Updated: Oct 17, 2008</ref>
** Macrofollicular
* Follicular adenomas can be described as "cold", "warm", or "hot" depending on their level of function.<ref name="urlEndocrine Pathology">{{cite web |url=http://library.med.utah.edu/WebPath/ENDOHTML/ENDO037.html |title=Endocrine Pathology |format= |work= |accessdate=2009-05-08}}</ref>  
** [[Adenomatoid tumor|Adenomatoid]]/[[Hyperplasia|hyperplastic]] [[nodules]]
* [[Histopathological]]ly, follicular adenomas can be classified according to their cellular architecture and relative amounts of cellularity and [[colloid]] into the following types depicted in the flowchart.
** [[Colloid]] [[adenomas]]
{{Familytree/start}}
** [[Nodular]] [[goiter]]
{{Familytree|boxstyle=background: #E0FFFF;| | | | | | | | | | | | | A01 | | | | | | | | | | | | | | | | | | |A01= Thyroid adenoma}}
** [[Lymphocytic thyroiditis]]
{{Familytree|boxstyle=background: #E0FFFF;| | |,|-|-|-|v|-|-|-|v|-|-|-|^|-|-|-|v|-|-|-|.| | | | | | | | | | | | | | | | | |}}
** [[Granulomatous thyroiditis]]
{{Familytree|boxstyle=background: #E0FFFF;| | B01 | | B02 | | B03 | | | | | | B04 | | B05 | | | | | | | | | | | | | | | | | | | |B01=Microfollicular adenoma (fetal adenoma)|B02=Macrofollicular adenoma (colloid adenoma)|B03=Hürthle cell adenoma (oxyphil or oncocytic tumor)|B04=Atypical embryonal adenoma|B05=Hyalinizing trabecular adenoma}}
 
{{Familytree/end}}
*For information on the classification of thyroid [[nodules]], [[Thyroid nodule classification|click here]].
* Below is a table with the description of different types of follicular adenoma:
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
|valign=top|
|+
! style="background: #4479BA; width: 50px;" | {{fontcolor|#FFF|Number}}
! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Type of follicular adenoma}}
! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Description}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
1
| style="padding: 5px 5px; background: #F5F5F5;" |
* Microfollicular adenoma (Fetal)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consist of small, closely packed follicles
* Have the potential for microinvasion
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
2
| style="padding: 5px 5px; background: #F5F5F5;" |
* Macrofollicular adenoma (colloid adenoma)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of large amount of [[colloid]]
* Do not have the potential for microinvasion
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
3
| style="padding: 5px 5px; background: #F5F5F5;" |
* Hürthle cell adenoma (oxyphil or oncocytic tumor)
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of oxyphil cells
* Have the potential for microinvasion
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
4
| style="padding: 5px 5px; background: #F5F5F5;" |
* Atypical embryonal adenoma
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of embryonic cells
* Have the potential for microinvasion
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
5
| style="padding: 5px 5px; background: #F5F5F5;" |
* Hyalinizing trabecular adenoma
| style="padding: 5px 5px; background: #F5F5F5;" |
* Consists of hyalinization
* Have the potential for microinvasion
|}


==Reference==
==Reference==
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Endocrinology]]
[[Category:Surgery]]

Latest revision as of 23:55, 11 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Thyroid adenoma may be classified based on FNA cytology into 6 groups include macrofollicular, adenomatoid, colloid adenomas, nodular goiter, lymphocytic thyroiditis and granulomatous thyroiditis.

Classification

Reference

  1. Cibas ES, Ali SZ (2009). "The Bethesda System for Reporting Thyroid Cytopathology". Thyroid. 19 (11): 1159–65. doi:10.1089/thy.2009.0274. PMID 19888858.