Testicular cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into two subtypes: germ cell tumors and non–germ cell tumors.

Classification

WHO Classification of testicular Tumors

WHO classifies testicular tumors as follows:^[1]^[2]


Testicular Cancer
Germ cell tumors	Sex-cord stromal tumors	Tumors containing both germ cell and sex-cord stromal elements	Miscellaneous tumors of the testis	Hematolymphoid tumors	Tumors of collecting duct and rete testis
Serous tumors: Benign (cystadenoma) Borderline tumors (serous borderline tumor) Malignant (serous adenocarcinoma) Mucinous tumors: Benign (cystadenoma) Borderline tumors (mucinous borderline tumor) Malignant (mucinous adenocarcinoma) Endometrioid tumors: Benign (cystadenoma) Borderline tumors (endometrioid borderline tumor) Malignant (endometrioid adenocarcinoma) Clear cell tumors: Benign Borderline tumors Malignant (clear cell adenocarcinoma) Transitional cell tumors: Brenner tumor Brenner tumor of borderline malignancy Malignant Brenner tumor Transitional cell carcinoma (non-Brenner type) Epithelial-stromal: Adenosarcoma Carcinosarcoma (formerly mixed Müllerian tumors)	Pure stromal tumors: Fibroma Cellular fibroma Thecoma Luteinized thecoma associated with sclerosing peritonitis Fibrosarcoma Sclerosing stromal tumor Signet-ring stromal tumor Microcystic stromal tumor Leydig cell tumor Steroid cell tumor Steroid cell tumor, malignant Pure sex cord tumors: Adult granulosa cell tumor Juvenile granulosa cell tumor Sertoli cell tumor Sex cord tumor with annular tubules Mixed sex cord-stromal tumors Sertoli-Leydig cell tumors - Well-differentiated - Moderately differentiated with heterologous elements - Poorly differentiated with heterologous elements - Retiform with heterologous elements Sex cord-stromal tumours, NOS*	Teratoma Immature Mature Solid Cystic (dermoid cyst) Dysgerminoma Endometrial Sinus tumors Embryonal carcinoma Polyembryoma Choriocarcinoma Mixed germ cell tumors tumors	Gonadoblastoma Germ cell sex cord-stromal tumor of nongonadoblastoma type Tumors of rete ovarii Mesothelial tumors Tumors of uncertain origin and miscellaneous tumors Gestational trophoblastic diseases Soft tissue tumors not specific to ovary Malignant lymphomas leukemias, and plasmacytomas Unclassified tumors Secondary (metastatic) tumors Tumor-like lesions

Testicular cancer may be classified according to WHO classification into two subtypes:

Germ cell tumors

Germ cell neoplasia in situ-derived

Seminomas
Non-seminomas

Choriocarcinoma
Other trophoblastic tumors

Teratoma, postpubertal type

Somatic malignant

Not germ cell neoplasia in situ-derived

Non–germ cell tumors

Sex cord stromal tumors

Mixed germ cell and stromal tumors

Gonadoblastoma

Adnexal and paratesticular tumors

Adenocarcinoma of the rete testis
Adenocarcinoma of the epididymis
Malignant mesothelioma

Other tumors

References

↑ Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
↑ Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

Template:WikiDoc Sources

[pmid27747907-1] Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.

[pmid26935559-2] Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

[1]

[2]

Testicular cancer classification

Overview

Classification

WHO Classification of testicular Tumors

References

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