Testicular cancer classification: Difference between revisions

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Latest revision as of 16:19, 28 May 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into six subtypes: germ cell tumors, sex-cord stromal tumors, tumors containing both germ cell and sex-cord stromal elements, miscellaneous tumors of the testis, hematolymphoid tumors, and tumors of collecting duct and rete testis.

Classification

WHO Classification of testicular Tumors

WHO classifies testicular tumors as follows:^[1]^[2]

Testicular Cancer
Germ cell tumors	Sex-cord stromal tumors	Miscellaneous tumors of the testis	Hematolymphoid tumors	Tumors of collecting duct and rete testis	Tumors containing both germ cell and sex-cord stromal elements
Germ cell tumors derived from germ cell neoplasia in situ: Non-invasive germ cell neoplasia Germ cell neoplasia in situ Specific forms of intratubular germ cell tumor neoplasia Tumors of a single histological type (pure forms) Seminoma Seminoma with syncytiotrophoblast cells Non-seminomatous germ cell tumors Embryonal carcinoma Yolk sac tumor, postpubertal-type Trophoblastic tumors Choriocarcinoma Non-choriocarcinomatous trophoblastic tumors Placental site trophoblastic tumor Epitheliol trophoblastic tumor Cystic trophoblastic tumor Teratoma, postpubertal-type Teratoma with somatic-type Non-seminomatous germ cell type tumor of more than one histological type Mixed germ cell tumors Germ cell tumors of unknown type Regressed germ cell tumors Germ cell tumors unrelated to germ cell neoplasia in situ: Spermatocytic tumor Teratoma, prepubertal-type Dermoid cyst Epidermoid cyst Well-differentiated neuroendocrine tumor (monodermal teratoma) Mixed teratoma and yolk sac tumor, prepubertal-type Yolk sac tumor, prepubertal-type	Pure tumors Leydig cell tumor Malignant leydig cell tumor Sertoli cell tumor Malignant Sertoli cell tumor Large cell calcifying Sertoli cell tumor Intratubular large cell hyalinizing Sertoli cell neoplasia Granulosa cell tumor Adult granulosa cell tumor Juvenile granulosa cell tumor Tumors in the fibroma-thecoma group Mixed and unclassified sex-stromal tumors Mixed sex cord-stromal tumor Unclassified sex cord-stromal tumor	Ovarian epithelial-type tumors Serous cystadenoma Serous tumor of borderline malignancy Serous cystadenocarcinoma Mucinous borderline tumor Mucinous cystadenocarcinoma Endometrioid adenocarcinoma Clear cell adenocarcinoma Brenner tumor Juvenile Xanthogranuloma Hemangioma	Diffuse large B-cell lymphoma Follicular lymphoma, NOS Extranodal NK/T-cell lymphoma, nasal type Plasmacytoma Myeloid sarcoma Rosai-Dorfman disease	Adenoma Adenocarcinoma	Gonadoblastoma

References

↑ Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
↑ Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

Template:WikiDoc Sources |}

[pmid27747907-1] Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.

[pmid26935559-2] Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
-{{CMG}}
 {{Testicular cancer}}
+{{CMG}}; {{AE}} {{G.D.}}, {{SC}}
 ==Overview==
+Testicular cancer is a very rare type of [[Cancer (disease)|cancer]]. Based on the [[histopathological]] features, testicular cancer may be classified into six subtypes: [[germ cell tumors]], [[Sex (activity)|sex]]-[[cord]] [[stromal]] [[tumors]], [[tumors]] containing both [[germ cell]] and [[Sex (activity)|sex]]-[[cord]] [[stromal]] elements, miscellaneous [[tumors]] of the [[testis]], hematolymphoid [[tumors]], and [[tumors]] of [[collecting duct]] and [[rete testis]].
 ==Classification==
-=== Germ cell tumors of the testis ===
+=== WHO Classification of testicular Tumors ===
-{{main|Germ cell tumor}}
+'''WHO''' classifies testicular tumors as follows:<ref name="pmid27747907">{{cite journal |vauthors=Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM |title=The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel |journal=Histopathology |volume=70 |issue=3 |pages=335–346 |date=February 2017 |pmid=27747907 |doi=10.1111/his.13102 |url=}}</ref><ref name="pmid26935559">{{cite journal |vauthors=Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM |title=The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours |journal=Eur. Urol. |volume=70 |issue=1 |pages=93–105 |date=July 2016 |pmid=26935559 |doi=10.1016/j.eururo.2016.02.029 |url=}}</ref>
-* Mixed (usually teratoma plus another)
+{| class="wikitable"
-* [[Seminoma]] ([[germinoma]] of the testis)
+|- style="vertical-align:top;"
-* [[Embryonal carcinoma]]
+! colspan="6" style="background:#4479BA; color: #FFFFFF;" align="center" + |Testicular Cancer
-* [[Teratoma]] (pure)
+|-
-* [[Choriocarcinoma]]
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Germ cell tumors
-* [[Gonadoblastoma]]
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Sex-cord stromal tumors
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Miscellaneous tumors of the testis
-Also:  Intratubular germ cell [[neoplasm]]s (the in-situ stage of germ cell tumors)
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Hematolymphoid tumors
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Tumors of collecting duct and rete testis
-===Non-germ cell tumors of the testis===
+! style="background:#4479BA; color: #FFFFFF;" align="center" + |Tumors containing both germ cell and sex-cord stromal elements
+|- style="vertical-align:top;"
-* [[Sertoli-Leydig cell tumour|Sertoli-Leydig cell tumor]] (usually [[benign]])
+|'''[[Germ cell tumors]] derived from [[Germ cell neoplasm|germ cell neoplasia]] [[in situ]]:'''
-* Gonadoblastomas
+* Non-invasive [[germ cell]] [[neoplasia]]
+**[[Germ cell]] [[neoplasia]] [[in situ]]
+**Specific forms of intratubular [[germ cell]] tumor [[neoplasia]]
+* [[Tumor|Tumors]] of a single [[histological]] type (pure forms)
+**[[Seminoma]]
+**[[Seminoma|Seminoma with syncytiotrophoblast cells]]
+**Non-seminomatous [[germ cell]] [[tumors]]
+**[[Embryonal carcinoma]]
+**[[Yolk sac tumor]], postpubertal-type
+**[[Trophoblastic|Trophoblastic tumors]]
+***[[Choriocarcinoma]]
+***Non-choriocarcinomatous [[Trophoblastic|trophoblastic tumors]]
+***[[Placental]] site [[trophoblastic]] [[tumor]]
+***Epitheliol [[Trophoblastic|trophoblastic tumor]]
+***[[Cystic]] [[trophoblastic]] tumor
+**[[Teratoma]], postpubertal-type
+**[[Teratoma]] with somatic-type
+*Non-seminomatous [[Germ cell tumor|germ cell type tumor]] of more than one [[histological]] type
+**[[Germ cell tumors|Mixed germ cell tumors]]
+*[[Germ cell tumors]] of unknown type
+**Regressed [[germ cell tumors]]
+'''[[Germ cell tumors]] unrelated to [[Germ cell neoplasm|germ cell neoplasia]] [[in situ]]:'''
+*Spermatocytic [[tumor]]
+*[[Teratoma]], prepubertal-type
+**[[Dermoid cyst]]
+**[[Epidermoid cyst]]
+**Well-differentiated [[neuroendocrine]] [[tumor]] ([[monodermal teratoma]])
+*Mixed [[teratoma]] and [[yolk sac tumor]], prepubertal-type
+*[[Yolk sac tumor]], prepubertal-type
+|
+*Pure [[tumors]]
+*[[Leydig cell tumor]]
+**[[Leydig cell tumor|Malignant leydig cell tumor]]
+*[[Sertoli cell|Sertoli cell tumor]]
+**[[Malignant]] [[Sertoli cell]] [[tumor]]
+**[[Large cell]] calcifying [[Sertoli cell]] [[tumor]]
+**Intratubular large cell hyalinizing [[Sertoli cell]] [[neoplasia]]
+*[[Granulosa cell tumor]]
+**[[Granulosa cell tumor|Adult granulosa cell tumor]]
+**[[Granulosa cell tumor|Juvenile granulosa cell tumor]]
+*[[Tumors]] in the [[fibroma]]-[[thecoma]] group
+*Mixed and unclassified sex-[[Stromal|stromal tumors]]
+*Mixed [[sex cord-stromal tumor]]
+*Unclassified [[sex cord-stromal tumor]]
+|'''[[Ovarian]] epithelial-type tumors'''
+*[[Serous]] cystadenoma
+*Serous [[tumor]] of borderline [[malignancy]]
+*Serous cystadenocarcinoma
+*[[Mucinous]] borderline [[tumor]]
+*Mucinous cystadenocarcinoma
+*[[Endometrioid tumor|Endometrioid]] [[adenocarcinoma]]
+*[[Adenocarcinoma|Clear cell adenocarcinoma]]
+*Brenner tumor
+'''Juvenile Xanthogranuloma'''
-===Secondary tumors of the testis===
+'''Hemangioma'''
-* [[Lymphoma]]
+|
-* Leukemic infiltration of the testis
+*[[Diffuse large B-cell lymphoma]]
-* [[Metastasis|Metastatic]] tumors
+*[[Follicular lymphoma]], NOS
+*[[Extranodal NK-T-cell lymphoma|Extranodal]] [[Lymphoma|NK/T-cell lymphoma]], nasal type
+*[[Plasmacytoma]]
+*[[Myeloid]] [[sarcoma]]
+*[[Rosai-Dorfman disease]]
+|
+*[[Adenoma]]
+*[[Adenocarcinoma]]
+|
+*[[Gonadoblastoma]]
+|}
 ==References==
@@ Line 36: / Line 99: @@
 [[Category:Andrology]]
 [[Category:Types of cancer]]
+ [[Category:Up-To-Date]]
 [[Category:Oncology]]
-[[Category:Mature chapter]]
+[[Category:Medicine]]
+[[Category:Urology]]
+|}