Terbutaline (oral)

Terbutaline (oral)

Clinical data
Pregnancy category	B
Routes of administration	SQ, Oral, Inhaled
ATC code	R03AC03 (WHO) R03CC03 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Metabolism	GI tract (oral), liver; CYP450: unknown
Elimination half-life	urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h
Identifiers
IUPAC name 5-(1-hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol
CAS Number	23031-25-6
PubChem CID	5403
DrugBank	APRD00589
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H19NO3
Molar mass	225.284 g/mol

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Overview

Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β₂-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.

Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. It is a pregnancy category 'B' medication and is routinely prescribed to stop contractions.

Side Effects

Maternal - tachycardia, nervousness, tremors, headache and possible pulmonary edema. Fetal - tachycardia and hypoglycemia. Terbutaline is preferred over Ritodrine because it has minimal effects on blood pressure.

References

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