Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Associate Editor-In-Chief: Atif Mohammad, M.D.
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Overview
SYNTAX which is the abbreviation for "Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery" was a prospective clinical trial conducted in 85 sites in 17 countries across Europe and the United States.The purpose of this study was to assess objective revascularization strategy and treatment protocol for patients with previously untreated 3-vessel disease or left main coronary artery disease and identify the populations for whom only one will be better.Previous clinical trials comparing bare metal stents with CABG have shown similar survival rates but higher revascularization rates in patients having bare metal stents. Randomized clinical trials have also shown Drug Eluting Stents (DES)as compared with Bare Metal Stents (BMS), to show better results in terms of repeat revascularization, myocardial infarction and deaths especially in more complex anatomical cases .Currently, the guidelines for 3 vessel disease or left main is the patient to go for bypass surgery.The SYNTAX trial was conducted to assess the efficacy of Taxus which is a Paclitaxel coated drug eluting stent as compared to CABG for effective means of revascularization in patients with three vessel disease or left main disease.[1]
- ↑ Eagle KA, Guyton RA, Davidoff R; et al. (2004). "ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery)". Circulation. 110 (14): e340–437. PMID 15466654. Unknown parameter
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