Staphylococcal scalded skin syndrome

Staphylococcal scalded skin syndrome
ICD-10	L00
ICD-9	695.81
DiseasesDB	29437
eMedicine	derm/402  emerg/782
MeSH	D013206

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Staphylococcal scalded skin syndrome, SSSS, also known as Pemphigus neonatorum or Ritter's disease, is a dermatological condition caused by Staphylococcus aureus.

Pathophysiology

The syndrome is induced by 2 epidermolytic exotoxins A and B, which are released by S. aureus and cause the epidermis to detach from the underlying dermis. One of the exotoxins is produced by the bacterial chromosome, while the other is produced by a plasmid. (Bacterial plasmids are pieces of self-replicating DNA that often code for secondary characteristics, such as antibiotic resistance, and toxin production.)

Symptoms

The disease presents with the widespread formation of fluid filled blisters that are thin walled and easily ruptured. Ritter's Disease of the Newborn is the most severe form of SSSS with similar signs and symptoms.

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