Splenic marginal zone lymphoma: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(15 intermediate revisions by 5 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Infobox_Disease |
'''For patient information, click [[Non-Hodgkin lymphoma (patient information)|here]]'''
  Name          = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB    = |
  ICD10          = |
  ICD9          = |
  ICDO          = 9689/3 |
  OMIM          = |
  MedlinePlus    = |
  MeshID        = |
}}
'''For patient information, click [[Splenic marginal zone lymphoma (patient information)|here]]'''
{{Splenic marginal zone lymphoma}}
{{Splenic marginal zone lymphoma}}
{{CMG}}
{{CMG}}; {{AE}} {{Affan}}, {{AS}}


{{SK}} SMZL, SLVL, Splenic marginal zone B-cell lymphoma, Splenic B-cell marginal zone lymphoma Splenic lymphoma with circulating villous lymphocytes, splenic lymphoma with villous lymphocytes,
==[[Splenic marginal zone lymphoma overview|Overview]]==


==[[Splenic marginal zone lymphoma historical perspective|Historical Perspective]]==


==Molecular Findings==
==[[Splenic marginal zone lymphoma classification|Classification]]==


===Immunophenotype===
==[[Splenic marginal zone lymphoma pathophysiology|Pathophysiology]]==


{| class="wikitable" style="width: 20em; text-align: left; font-size: 100%;"
==[[Splenic marginal zone lymphoma causes|Causes]]==
|-
! '''Antigen'''
| '''Status'''
|-
! [[CD20]]
| Positive
|-
! [[CD79a]]
| Positive
|-
! [[CD5]]
| Negative
|-
! [[CD10]]
| Negative
|-
! [[CD23]]
| Negative
|-
! [[CD43]]
| Negative
|-
! [[cyclin D1]]
| Negative
|-
|}


The relevant markers that define the immunophenotype for SMZL are shown in the table to the right.<ref name="isa1">
==[[Splenic marginal zone lymphoma differential diagnosis|Differentiating Splenic marginal zone lymphoma from other Diseases]]==
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7949139&query_hl=17&itool=pubmed_ExternalLink]
Isaacson PG, Matutes E, Burke M, Catovsky D. "The histopathology of splenic lymphoma with villous lymphocytes." '''Blood'''. 1994 Dec 1;84(11):3828-34. PMID: 7949139</ref><ref name="mat1">
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8123845&query_hl=20&itool=pubmed_ExternalLink]
Matutes E, Morilla R, Owusu-Ankomah K, Houlihan A, Catovsky D. "The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders."
'''Blood'''. 1994 Mar 15;83(6):1558-62. PMID: 8123845</ref> The  lack of [[CD5]] expression is helpful in the discrimination between SMZL and [[chronic lymphocytic leukemia]]/[[small lymphocytic lymphoma]], and the lack of [[CD10]] expression argues against [[follicular lymphoma]]. [[Mantle cell lymphoma]] is excluded due to the lack of [[CD5]] and [[cyclin-D1]] expression.<ref name="sav1">
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9688179&query_hl=22&itool=pubmed_ExternalLink]
Savilo E, Campo E, Mollejo M, Pinyol M, Piris MA, Zukerberg LR, Yang WI, Koelliker DD, Nguyen PL, Harris NL. "Absence of cyclin D1 protein expression in splenic marginal zone lymphoma."
'''Mod Pathol'''. 1998 Jul;11(7):601-6. PMID: 9688179</ref>


===Genetics===
==[[Splenic marginal zone lymphoma epidemiology and demographics|Epidemiology and Demographics]]==


Clonal rearrangements of the [[immunoglobulin]] genes (heavy and light chains) are frequently seen.<ref name="dun1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9635678&query_hl=24&itool=pubmed_ExternalLink]
==[[Splenic marginal zone lymphoma risk factors|Risk Factors]]==
Dunn-Walters DK, Boursier L, Spencer J, Isaacson PG. "Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation." '''Hum Pathol'''. 1998 Jun;29(6):585-93. PMID: 9635678</ref> The deletion 7q21-32 is seen in 40% of SMZL patients, and translocations of the CDK6 gene located at 7q21 have also been reported.<ref name="cor1">
 
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10597225&query_hl=28&itool=pubmed_ExternalLink]
==[[Splenic marginal zone lymphoma screening|Screening]]==
Corcoran MM, Mould SJ, Orchard JA, Ibbotson RE, Chapman RM, Boright AP, Platt C, Tsui LC, Scherer SW, Oscier DG. "Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations." '''Oncogene'''. 1999 Nov 4;18(46):6271-7. PMID: 10597225</ref>
 
==[[Splenic marginal zone lymphoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Splenic marginal zone lymphoma diagnostic study of choice|Diagnostic study of choice]] | [[Splenic marginal zone lymphoma staging|Staging]] | [[Splenic marginal zone lymphoma history and symptoms|History and Symptoms]] | [[Splenic marginal zone lymphoma physical examination|Physical Examination]] | [[Splenic marginal zone lymphoma laboratory findings|Laboratory Findings]] | [[Splenic marginal zone lymphoma biopsy|Biopsy]] |  [[Splenic marginal zone lymphoma CT|CT]] | [[Splenic marginal zone lymphoma MRI|MRI]] | [[Splenic marginal zone lymphoma ultrasound|Ultrasound]] | [[Splenic marginal zone lymphoma other imaging findings|Other Imaging Findings]] | [[Splenic marginal zone lymphoma other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Splenic marginal zone lymphoma medical therapy|Medical Therapy]] | [[Splenic marginal zone lymphoma surgery|Surgery]] | [[Splenic marginal zone lymphoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Splenic marginal zone lymphoma future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
 
[[Splenic marginal zone lymphoma case study one|Case #1]]


==References==
<div class="references-small"><references/></div>


{{Hematological malignancy histology}}
{{Hematological malignancy histology}}
 
[[Category:Disease]]
[[Category:Hematology|Splenic marginal zone lymphoma]]
[[Category:Hematology|Splenic marginal zone lymphoma]]
[[Category:Types of cancer|Splenic marginal zone lymphoma]]
[[Category:Types of cancer|Splenic marginal zone lymphoma]]
Line 78: Line 44:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Immunology]]

Latest revision as of 15:55, 22 January 2019

For patient information, click here

Splenic marginal zone lymphoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Splenic marginal zone lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Biopsy

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Splenic marginal zone lymphoma On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Splenic marginal zone lymphoma

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Splenic marginal zone lymphoma

CDC on Splenic marginal zone lymphoma

Splenic marginal zone lymphoma in the news

Blogs on Splenic marginal zone lymphoma

Directions to Hospitals Treating Splenic marginal zone lymphoma

Risk calculators and risk factors for Splenic marginal zone lymphoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Muhammad Affan M.D.[2], Sowminya Arikapudi, M.B,B.S. [3]

Synonyms and keywords: SMZL, SLVL, Splenic marginal zone B-cell lymphoma, Splenic B-cell marginal zone lymphoma Splenic lymphoma with circulating villous lymphocytes, splenic lymphoma with villous lymphocytes,

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Splenic marginal zone lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | Staging | History and Symptoms | Physical Examination | Laboratory Findings | Biopsy | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1



Template:WikiDoc Sources