Smallpox natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Natural History

Complications

Common complications of smallpox include:

  • Respiratory complications (viral or bacterial):

Prognosis

The prognosis of smallpox depends on the form of the disease:

Variola major

Ordinary smallpox

  • Fatality rate about 10% for patients with discrete lesions and 60% for those with confluent lesions[1]
  • In fatal cases, death usually occurs between the tenth and sixteenth days of the illness
  • Unclear cause of death, however infection was known to involve multiple organs
  • Possible contributors include:

Flat-type smallpox

Hemorrhagic-type smallpox

Variola minor

References

  1. Moore, Zack S; Seward, Jane F; Lane, J Michael (2006). "Smallpox". The Lancet. 367 (9508): 425–435. doi:10.1016/S0140-6736(06)68143-9. ISSN 0140-6736.

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