Small cell carcinoma of the lung history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
Small cell lung cancer comprises 15% to 25% of bronchogenic carcinomas and it is the cancer most commnoly associated with a plethora of [[paraneoplastic syndromes]].<ref name="pmid18316005">{{cite journal| author=Sher T, Dy GK, Adjei AA| title=Small cell lung cancer. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 3 | pages= 355-67 | pmid=18316005 | doi=10.4065/83.3.355 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18316005 }} </ref> It usually develops in the upper airways and involves the [[hilum]] and [[mediastinum]]. Most of the times, evidence of regional or distant metastases is found at the time patients present with small cell lung carcinoma. <ref name="pmid17873166">{{cite journal| author=Spiro SG, Gould MK, Colice GL, American College of Chest Physicians| title=Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition). | journal=Chest | year= 2007 | volume= 132 | issue= 3 Suppl | pages= 149S-160S | pmid=17873166 | doi=10.1378/chest.07-1358 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17873166 }} </ref> | Small cell lung cancer comprises 15% to 25% of bronchogenic carcinomas and it is the cancer most commnoly associated with a plethora of [[paraneoplastic syndromes]].<ref name="pmid18316005">{{cite journal| author=Sher T, Dy GK, Adjei AA| title=Small cell lung cancer. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 3 | pages= 355-67 | pmid=18316005 | doi=10.4065/83.3.355 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18316005 }} </ref> It usually develops in the upper airways and involves the [[hilum]] and [[mediastinum]]. Most of the times, evidence of regional or distant metastases is found at the time patients present with small cell lung carcinoma. <ref name="pmid17873166">{{cite journal| author=Spiro SG, Gould MK, Colice GL, American College of Chest Physicians| title=Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition). | journal=Chest | year= 2007 | volume= 132 | issue= 3 Suppl | pages= 149S-160S | pmid=17873166 | doi=10.1378/chest.07-1358 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17873166 }} </ref> | ||
==History== | ==History== | ||
==Symptoms== | ==Symptoms== | ||
Early small cell carcinoma of the lung does not have any symptoms. | Early small cell carcinoma of the lung does not have any symptoms. Initial presenting symptoms may be airways related, but are often constitutional and attributable to metastases:<ref name="pmid2181676">{{cite journal| author=Grippi MA| title=Clinical aspects of lung cancer. | journal=Semin Roentgenol | year= 1990 | volume= 25 | issue= 1 | pages= 12-24 | pmid=2181676 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2181676 }} </ref><ref name="pmid4813837">{{cite journal| author=Hyde L, Hyde CI| title=Clinical manifestations of lung cancer. | journal=Chest | year= 1974 | volume= 65 | issue= 3 | pages= 299-306 | pmid=4813837 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4813837 }} </ref> | ||
: | |||
:* | :*[[Cough]] 75% | ||
:*[[Weight loss]] 68% | |||
:*[[Dyspnea]] 60% | |||
:*[[Chest pain]] 49% | |||
:*[[Hemoptysis]] 35% | |||
:*[[Bone pain]] 25% | |||
:*New onset of wheezing | :*[[Clubbing]] 20% | ||
:*[[Fever]] 20% | |||
:*[[Weakness]] 10% | |||
:*[[Superior vena cava obstruction sydrome]] 4% | |||
:*[[Dysphagia]] 2% | |||
:*New onset of [[wheezing]] and [[stridor]] 2% | |||
Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible. | Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible. |
Revision as of 17:04, 9 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-In-Chief: Guillermo Rodriguez Nava, M.D. [2]
Overview
Small cell lung cancer comprises 15% to 25% of bronchogenic carcinomas and it is the cancer most commnoly associated with a plethora of paraneoplastic syndromes.[1] It usually develops in the upper airways and involves the hilum and mediastinum. Most of the times, evidence of regional or distant metastases is found at the time patients present with small cell lung carcinoma. [2]
History
Symptoms
Early small cell carcinoma of the lung does not have any symptoms. Initial presenting symptoms may be airways related, but are often constitutional and attributable to metastases:[3][4]
- Cough 75%
- Weight loss 68%
- Dyspnea 60%
- Chest pain 49%
- Hemoptysis 35%
- Bone pain 25%
Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible.
References
- ↑ Sher T, Dy GK, Adjei AA (2008). "Small cell lung cancer". Mayo Clin Proc. 83 (3): 355–67. doi:10.4065/83.3.355. PMID 18316005.
- ↑ Spiro SG, Gould MK, Colice GL, American College of Chest Physicians (2007). "Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition)". Chest. 132 (3 Suppl): 149S–160S. doi:10.1378/chest.07-1358. PMID 17873166.
- ↑ Grippi MA (1990). "Clinical aspects of lung cancer". Semin Roentgenol. 25 (1): 12–24. PMID 2181676.
- ↑ Hyde L, Hyde CI (1974). "Clinical manifestations of lung cancer". Chest. 65 (3): 299–306. PMID 4813837.