Small cell carcinoma of the lung epidemiology and demographics: Difference between revisions

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Latest revision as of 22:09, 3 September 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2];Rim Halaby, M.D. [3] Mirdula Sharma, MBBS [4]

Overview

Small cell lung cancer (SCLC) represents 13.4% of all the lung cancers in the United States. The majority of small cell lung cancer occurs among patients > 65 years of age. The age-adjusted incidence of small cell lung cancer in the United States is reported to be 6.23 per 100,000 individuals in 2011.

Epidemiology and Demographics

Incidence

In the United States, the age-adjusted incidence of small cell carcinoma is reported to be 8.94 per 100,000 individuals between 1975 and 2011.^[1]
- The age-adjusted incidence of small cell lung cancer in 1975: 6.64 per 100,000 individuals
- The age-adjusted incidence of small cell lung cancer in 1998: 11.39 per 100,000 individuals
- The age-adjusted incidence of small cell lung cancer in 2000: 8.80 per 100,000 individuals
- The age-adjusted incidence of small cell lung cancer in 2011: 6.23 per 100,000 individuals

Small cell lung cancer accounts for 13.4% of all histologically confirmed cases of lung cancers.

Stage Distribution

Among patients with small cell carcinoma, the percentages of the stages of the disease between 2004 and 2010 in the United States are:^[1]
- Localized: 5%
- Regional: 21%
- Distant: 72%
- Unstaged: 3%

Age

Most small cell lung cancers occur in patients > 65 years of age.^[1]
While the overall age-adjusted incidence of small cell lung cancer in the United States between 2007 and 2011 is 7.2 per 100,000 individuals, the age-adjusted incidence of small cell lung cancer by age category is:
- Under 65 years: 2.6 per 100,000
- 65 and over: 3.8 per 100,000

Gender

In the past decade, the male to female ratio of the incidence of small cell lung cancer has decreased and the incidence per gender has come closer.
The incidence of small cell lung cancer in different years is:^[1]
- In 1975: Male to female ratio was 10.33:3.79 per 100,000 individuals
- In 2011: Male to female ratio was 6.81:5.82 per 100,000 individuals
Shown below is an image depicting the incidence of small cell lung cancer by gender. Note the decrease in trend in the incidence of small cell lung cancer in males:^[2]

Race

Shown below is a table depicting the percentage of small cell lung cancer among patients with histologically confirmed lung cancer by race according to the SEER reports in 18 areas in the United States between 2007 and 2011:^[1]

Race	All Races	White	Black	Asian/Pacific Islander	American Indian/Alaska Native*	Hispanic
Percentage of small cell lung cancer	13.4%	14.1%	10.5%	7.9%	18%	11.5%
Adapted from SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD^[1] *Estimates for American Indian/Alaska Native are based on the CHSDA (Contract Health Service Delivery Area) counties.

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
↑ NCCN Clinical Practice Guidelines in Oncology. Small Cell Lung Cancer, version 2.2014

Template:WikiDoc Sources

[SEER-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.

[NCCN-2] NCCN Clinical Practice Guidelines in Oncology. Small Cell Lung Cancer, version 2.2014

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Small cell carcinoma of the lung}}
-{{CMG}}{{AE}} {{AL}}
+{{CMG}}; {{AE}} {{AL}};{{Rim}}{{MGS}}
 ==Overview==
-Small cell lung cancer represents 13.4% of all lung cancers in the US and it is most common in white population.
+Small cell lung cancer (SCLC) represents 13.4% of all the [[Lung cancer|lung cancers]] in the United States.  The majority of small cell lung cancer occurs among patients > 65 years of age. The age-adjusted [[Incidence (epidemiology)|incidence]] of small cell lung cancer in the United States is reported to be 6.23 per 100,000 individuals in 2011.
-==Epidemiology==
+==Epidemiology and Demographics==
 ===Incidence===
-* The expected number for new cases of [[lung cancer]] in the United States for 2014 is 224,210.<ref name="SiegelMa2014">{{cite journal|last1=Siegel|first1=Rebecca|last2=Ma|first2=Jiemin|last3=Zou|first3=Zhaohui|last4=Jemal|first4=Ahmedin|title=Cancer statistics, 2014|journal=CA: A Cancer Journal for Clinicians|volume=64|issue=1|year=2014|pages=9–29|issn=00079235|doi=10.3322/caac.21208}}</ref>   small cell lung cancer represents 13.6% of all lung cancers. 30,397 cases per year of small cell lung cancer  have been reported between 2007 and 2011.<ref name="SEER"></ref>   The male to female ratio has decreased, and overall, the incidence of lung cancer has decreased.
+* In the United States, the age-adjusted [[incidence]] of small cell carcinoma is reported to be 8.94 per 100,000 individuals between 1975 and 2011.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
+**'''The age-adjusted [[incidence]] of small cell lung cancer in 1975:''' 6.64 per 100,000 individuals
+**'''The age-adjusted [[incidence]] of small cell lung cancer in 1998:''' 11.39 per 100,000 individuals
+**'''The age-adjusted [[incidence]] of small cell lung cancer in 2000:''' 8.80 per 100,000 individuals
+**'''The age-adjusted [[incidence]] of small cell lung cancer in 2011:''' 6.23 per 100,000 individuals
+* Small cell lung cancer accounts for 13.4% of all [[histologically]] confirmed cases of [[Lung cancer|lung cancers]].
+===Stage Distribution===
+*Among [[Patient|patients]] with small cell carcinoma, the percentages of the stages of the [[disease]] between 2004 and 2010 in the United States are:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
+**'''Localized:''' 5%
+**'''Regional:''' 21%
+**'''Distant:''' 72%
+**'''Unstaged:''' 3%
-==Demographics==
 ===Age===
-* Most small cell lung cancer occur in patients > 65 years of age.  The incidence of small cell lung cancer in patients older than 65 years is 38.8 per 100,000, in contrast with 2.6 per 100,000 in patients younger than 65 years.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
+* Most small cell lung cancers occur in [[Patient|patients]] > 65 years of age.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
+* While the overall age-adjusted [[incidence]] of small cell lung cancer in the United States between 2007 and 2011 is 7.2 per 100,000 individuals, the age-adjusted [[incidence]] of small cell lung cancer by age category is:
+**'''Under 65 years:''' 2.6 per 100,000
+**'''65 and over:''' 3.8 per 100,000
 ===Gender===
-* Lung cancer is more prevalent in males, however, in the past decade this ratio has shifted. The male to female ratio has decreased and the incidence per gender has come closer. (US reported cases from 2006-2010: Male 116,000 vs Female 108,210).<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
+* In the past decade, the male to female ratio of the [[incidence]] of small cell lung cancer has decreased and the [[incidence]] per gender has come closer.
-* The incidence is decreasing in men but increasing in women.
+*The [[incidence]] of small cell lung cancer in different years is:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
-* In 1975, the incidence of small cell lung cancer in males was 10.33 per 100,000; and 3.79 per 100,000 in females. Compared to 2011, where the incidence of small cell lung cancer in males was 6.81 per 100,000; and 5.82 per 100,000 in females.
+**'''In 1975:''' Male to female ratio was 10.33:3.79 per 100,000 individuals
+**'''In 2011:''' Male to female ratio was 6.81:5.82 per 100,000 individuals
+* Shown below is an image depicting the [[incidence]] of small cell lung cancer by gender. Note the decrease in trend in the [[incidence]] of small cell lung cancer in males:<ref name="NCCN">[http://www.nccn.org/professionals/physician_gls/f_guidelines_nojava.asp NCCN Clinical Practice Guidelines in Oncology. Small Cell Lung Cancer, version 2.2014] </ref>
 <br>
@@ Line 23: / Line 41: @@
 ===Race===
-* African Americans have a high incidence of [[lung cancer]] overall, however, for small cell lung cancer the incidence is higher in white population.
+* Shown below is a table depicting the percentage of small cell lung cancer among [[Patient|patients]] with [[Histology|histologically]] confirmed [[lung cancer]] by race according to the [[SEER]] reports in 18 areas in the United States between 2007 and 2011:<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
-* For whites, the percentage for small cell lung cancer of the total cases of lung cancer between 2007 and 2011 is 14.1%; and for African Americans the percentage is 10.5%.<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref>
+{| style="cellpadding=0; cellspacing= 0; width: 600px;"
+|-
+| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''Race''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''All Races''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''White''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''Black''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''Asian/Pacific Islander'''  || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''American Indian/Alaska Native*'''  || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''Hispanic'''
+|-
+| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF; width: 10%" align="center" |'''Percentage of small cell lung cancer'''
+! style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" |13.4% !! style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" | 14.1% !! style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" | 10.5% !! style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" | 7.9% !! style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" | 18% !! style="font-size: 100; padding: 0 5px; background: #B8B8B8" align="left" | 11.5%
+|-
+| colspan="7" |<small>Adapted from SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD<ref name="SEER">Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.</ref> <br> *Estimates for American Indian/Alaska Native are based on the CHSDA (Contract Health Service Delivery Area) counties.</small>
+|}
 ==References==
@@ Line 33: / Line 60: @@
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 [[Category:Lung cancer]]
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