Sickle-cell disease surgery: Difference between revisions

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{{Sickle-cell disease}}
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==Overview==
==Overview==
There is generally no role for surgery in the primary management of sickle cell disease. However, certain surgeries can be done for specific complications.
Surgical intervention is generally not recommended for the management of sickle-cell disease. However, certain surgeries may be performed for specific complications.


==Surgery==
==Surgery==
Surgery is generally not used for treatment of sickle cell disease. However, elective splenectomy can be performed after the first episode of a splenic sequestration crisis.<ref name="pmid22924029">{{cite journal| author=Ballas SK, Kesen MR, Goldberg MF, Lutty GA, Dampier C, Osunkwo I et al.| title=Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management. | journal=ScientificWorldJournal | year= 2012 | volume= 2012 | issue=  | pages= 949535 | pmid=22924029 | doi=10.1100/2012/949535 | pmc=3415156 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22924029  }} </ref> Cholecystectomy can be done for patients who develop cholecystitis or symptoms of gallbladder disease. The cause of cholecystitis in sickle cell disease is due to the development of bilirubin stones (pigmented stones), which can cause inflammation of the gallbladder.<ref name="pmid22924029">{{cite journal| author=Ballas SK, Kesen MR, Goldberg MF, Lutty GA, Dampier C, Osunkwo I et al.| title=Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management. | journal=ScientificWorldJournal | year= 2012 | volume= 2012 | issue=  | pages= 949535 | pmid=22924029 | doi=10.1100/2012/949535 | pmc=3415156 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22924029  }} </ref> This occurs when hemoglobin breaks down to biliverdin then bilirubin. For patients who develop choledocholithiasis, endoscopic retrograde cholangiopancreatography (ERCP) can be done.  
Surgical intervention is generally not recommended for the management of sickle-cell disease. However, elective splenectomy can be performed after the first episode of a splenic sequestration crisis.<ref name="pmid22924029">{{cite journal| author=Ballas SK, Kesen MR, Goldberg MF, Lutty GA, Dampier C, Osunkwo I et al.| title=Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management. | journal=ScientificWorldJournal | year= 2012 | volume= 2012 | issue=  | pages= 949535 | pmid=22924029 | doi=10.1100/2012/949535 | pmc=3415156 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22924029  }} </ref> [[Cholecystectomy]] can be done for patients who develop [[cholecystitis\\ or symptoms of [[gallbladder disease]].<ref name="pmid22924029">{{cite journal| author=Ballas SK, Kesen MR, Goldberg MF, Lutty GA, Dampier C, Osunkwo I et al.| title=Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management. | journal=ScientificWorldJournal | year= 2012 | volume= 2012 | issue=  | pages= 949535 | pmid=22924029 | doi=10.1100/2012/949535 | pmc=3415156 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22924029  }} </ref> For patients who develop [[choledocholithiasis]], endoscopic retrograde cholangiopancreatography (ERCP) may be done.  


==References==
==References==
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{{reflist|2}}
[[Category:Hematology]]
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Revision as of 18:36, 24 October 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]

Overview

Surgical intervention is generally not recommended for the management of sickle-cell disease. However, certain surgeries may be performed for specific complications.

Surgery

Surgical intervention is generally not recommended for the management of sickle-cell disease. However, elective splenectomy can be performed after the first episode of a splenic sequestration crisis.[1] Cholecystectomy can be done for patients who develop [[cholecystitis\\ or symptoms of gallbladder disease.[1] For patients who develop choledocholithiasis, endoscopic retrograde cholangiopancreatography (ERCP) may be done.

References

  1. 1.0 1.1 Ballas SK, Kesen MR, Goldberg MF, Lutty GA, Dampier C, Osunkwo I; et al. (2012). "Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management". ScientificWorldJournal. 2012: 949535. doi:10.1100/2012/949535. PMC 3415156. PMID 22924029.