Sickle-cell disease history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
Symptoms of sickle-cell disease include mild pain in the arms an legs to severe pain from sickle cell crises and acute chest syndrome.
History
The location of vaso-occlusive episodes determines the types of symptoms a patient will experience. For example, vaso-occlusive crisis in the bones will cause bone pain. Bones, especially weight-bearing bones, are a common target of vaso-occlusive damage due to bone ischemia.
Symptoms
Common symptoms of sickle cell disease include:[1][2]
- Pain and/or bone pain
- Dactylitis
- Blurry vision
- Persistent and painful erection
- Numbness
- Tingling
- Motor skill loss
- Speech deficits
- Gait disturbance
- Leg ulceration
- Jaundice
Acute chest crisis
Symptoms of acute chest crisis include:[3][4]
References
- ↑ Lonergan GJ, Cline DB, Abbondanzo SL (2001). "Sickle cell anemia". Radiographics. 21 (4): 971–94. doi:10.1148/radiographics.21.4.g01jl23971. PMID 11452073.
- ↑ Prengler M, Pavlakis SG, Prohovnik I, Adams RJ (May 2002). "Sickle cell disease: the neurological complications". Ann. Neurol. 51 (5): 543–52. doi:10.1002/ana.10192. PMID 12112099.
- ↑ Desai PC, Ataga KI (June 2013). "The acute chest syndrome of sickle cell disease". Expert Opin Pharmacother. 14 (8): 991–9. doi:10.1517/14656566.2013.783570. PMID 23534969.
- ↑ Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, Nickerson B (March 1997). "Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease". Blood. 89 (5): 1787–92. PMID 9057664.