Sickle-cell disease history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
Common symptoms of sickle cell disease include:<ref name="pmid11452073">{{cite journal |vauthors=Lonergan GJ, Cline DB, Abbondanzo SL |title=Sickle cell anemia |journal=Radiographics |volume=21 |issue=4 |pages=971–94 |date=2001 |pmid=11452073 |doi=10.1148/radiographics.21.4.g01jl23971 |url=}}</ref> | Common symptoms of sickle cell disease include:<ref name="pmid11452073">{{cite journal |vauthors=Lonergan GJ, Cline DB, Abbondanzo SL |title=Sickle cell anemia |journal=Radiographics |volume=21 |issue=4 |pages=971–94 |date=2001 |pmid=11452073 |doi=10.1148/radiographics.21.4.g01jl23971 |url=}}</ref><ref name="pmid12112099">{{cite journal |vauthors=Prengler M, Pavlakis SG, Prohovnik I, Adams RJ |title=Sickle cell disease: the neurological complications |journal=Ann. Neurol. |volume=51 |issue=5 |pages=543–52 |date=May 2002 |pmid=12112099 |doi=10.1002/ana.10192 |url=}}</ref> | ||
*[[Pain and nociception|Pain]] and/or [[bone pain]] | *[[Pain and nociception|Pain]] and/or [[bone pain]] | ||
*[[Dactylitis]] | *[[Dactylitis]] | ||
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===Acute chest crisis=== | ===Acute chest crisis=== | ||
Symptoms of acute chest crisis include:<ref name="pmid23534969">{{cite journal |vauthors=Desai PC, Ataga KI |title=The acute chest syndrome of sickle cell disease |journal=Expert Opin Pharmacother |volume=14 |issue=8 |pages=991–9 |date=June 2013 |pmid=23534969 |doi=10.1517/14656566.2013.783570 |url=}}</ref> | Symptoms of acute chest crisis include:<ref name="pmid23534969">{{cite journal |vauthors=Desai PC, Ataga KI |title=The acute chest syndrome of sickle cell disease |journal=Expert Opin Pharmacother |volume=14 |issue=8 |pages=991–9 |date=June 2013 |pmid=23534969 |doi=10.1517/14656566.2013.783570 |url=}}</ref><ref name="pmid9057664">{{cite journal |vauthors=Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, Nickerson B |title=Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease |journal=Blood |volume=89 |issue=5 |pages=1787–92 |date=March 1997 |pmid=9057664 |doi= |url=}}</ref> | ||
*[[Fever]] | *[[Fever]] | ||
*[[Chest pain]] | *[[Chest pain]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
Symptoms of sickle-cell disease include mild pain in the arms an legs to severe pain from sickle cell crises and acute chest syndrome.
History
The location of vaso-occlusive episodes determines the types of symptoms a patient will experience. For example, vaso-occlusive crisis in the bones will cause bone pain. Bones, especially weight-bearing bones, are a common target of vaso-occlusive damage due to bone ischemia.
Symptoms
Common symptoms of sickle cell disease include:[1][2]
- Pain and/or bone pain
- Dactylitis
- Blurry vision
- Persistent and painful erection
- Numbness
- Tingling
- Motor skill loss
- Speech deficits
- Gait disturbance
- Leg ulceration
- Jaundice
Acute chest crisis
Symptoms of acute chest crisis include:[3][4]
References
- ↑ Lonergan GJ, Cline DB, Abbondanzo SL (2001). "Sickle cell anemia". Radiographics. 21 (4): 971–94. doi:10.1148/radiographics.21.4.g01jl23971. PMID 11452073.
- ↑ Prengler M, Pavlakis SG, Prohovnik I, Adams RJ (May 2002). "Sickle cell disease: the neurological complications". Ann. Neurol. 51 (5): 543–52. doi:10.1002/ana.10192. PMID 12112099.
- ↑ Desai PC, Ataga KI (June 2013). "The acute chest syndrome of sickle cell disease". Expert Opin Pharmacother. 14 (8): 991–9. doi:10.1517/14656566.2013.783570. PMID 23534969.
- ↑ Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, Nickerson B (March 1997). "Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease". Blood. 89 (5): 1787–92. PMID 9057664.