Sepsis pathophysiology: Difference between revisions
Hardik Patel (talk | contribs) No edit summary |
Hardik Patel (talk | contribs) |
||
| Line 6: | Line 6: | ||
==Overview== | ==Overview== | ||
The immunological response that causes sepsis is a systemic inflammatory response causing widespread activation of [[inflammation]] and [[coagulation]] pathways. This may progress to dysfunction of the [[septic shock|circulatory system]] and, even under optimal treatment, may result in the [[multiple organ dysfunction syndrome]] and eventually [[death]]. A subclass of [[distributive shock]], shock refers specifically to decreased tissue [[perfusion]] resulting in end-organ dysfunction. | The immunological response that causes sepsis is a systemic inflammatory response causing widespread activation of [[inflammation]] and [[coagulation]] pathways. This may progress to dysfunction of the [[septic shock|circulatory system]] and, even under optimal treatment, may result in the [[multiple organ dysfunction syndrome]] and eventually [[death]]. A subclass of [[distributive shock]], shock refers specifically to decreased tissue [[perfusion]] resulting in end-organ dysfunction. [[Cytokines]] [[TNFα]], [[interleukin|IL]]-1β, [[interferon]] γ, [[interleukin|IL]]-6 released in a large scale inflammatory response results in massive [[vasodilation]], increased [[capillary]] permeability, decreased systemic vascular resistance, and [[hypotension]]. Hypotension reduces tissue perfusion pressure and thus tissue [[Hypoxia (medical)|hypoxia]] ensues. Finally, in an attempt to offset decreased [[blood pressure]], [[ventricular]] dilatation and [[myocardium|myocardial]] dysfunction will occur. | ||
==References== | ==References== | ||
Revision as of 13:19, 18 December 2012
|
Sepsis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Sepsis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Sepsis pathophysiology |
|
Risk calculators and risk factors for Sepsis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2];
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Overview
The immunological response that causes sepsis is a systemic inflammatory response causing widespread activation of inflammation and coagulation pathways. This may progress to dysfunction of the circulatory system and, even under optimal treatment, may result in the multiple organ dysfunction syndrome and eventually death. A subclass of distributive shock, shock refers specifically to decreased tissue perfusion resulting in end-organ dysfunction. Cytokines TNFα, IL-1β, interferon γ, IL-6 released in a large scale inflammatory response results in massive vasodilation, increased capillary permeability, decreased systemic vascular resistance, and hypotension. Hypotension reduces tissue perfusion pressure and thus tissue hypoxia ensues. Finally, in an attempt to offset decreased blood pressure, ventricular dilatation and myocardial dysfunction will occur.