Sepsis pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
Line 14: | Line 14: | ||
*[[Septic shock]] | *[[Septic shock]] | ||
*[[Systemic inflammatory response syndrome]] (SIRS) | *[[Systemic inflammatory response syndrome]] (SIRS) | ||
==References== | |||
{{Reflist|2}} | |||
[[Category:Medical emergencies]] | [[Category:Medical emergencies]] | ||
[[Category:Intensive care medicine]] | [[Category:Intensive care medicine]] | ||
Line 24: | Line 28: | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 12:13, 19 September 2012
Sepsis Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Sepsis pathophysiology On the Web |
American Roentgen Ray Society Images of Sepsis pathophysiology |
Risk calculators and risk factors for Sepsis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2];
Overview
The immunological response that causes sepsis is a systemic inflammatory response causing widespread activation of inflammation and coagulation pathways. This may progress to dysfunction of the circulatory system and, even under optimal treatment, may result in the multiple organ dysfunction syndrome and eventually death. A subclass of distributive shock, shock refers specifically to decreased tissue perfusion resulting in end-organ dysfunction. Cytokines TNFα, IL-1β, IL-6 released in a large scale inflammatory response results in massive vasodilation, increased capillary permeability, decreased systemic vascular resistance, and hypotension. Hypotension reduces tissue perfusion pressure and thus tissue hypoxia ensues. Finally, in an attempt to offset decreased blood pressure, ventricular dilatation and myocardial dysfunction will occur.
Related Chapters
- Meningococcemia
- Anaphylactic shock
- Cardiogenic shock
- Neurogenic shock
- Sepsis
- Shock
- Septic shock
- Systemic inflammatory response syndrome (SIRS)