Sepsis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
A subclass of [[distributive shock]], shock refers specifically to decreased tissue [[perfusion]] resulting in end-organ dysfunction. [[Cytokines]] TNFα, IL-1β, IL-6 released in a large scale inflammatory response results in massive [[vasodilation]], increased [[capillary]] permeability, decreased systemic vascular resistance, and [[hypotension]]. Hypotension reduces tissue perfusion pressure and thus tissue [[Hypoxia (medical)|hypoxia]] ensues. Finally, in an attempt to offset decreased [[blood pressure]], [[ventricular]] dilatation and [[myocardium|myocardial]] dysfunction will occur.== | A subclass of [[distributive shock]], shock refers specifically to decreased tissue [[perfusion]] resulting in end-organ dysfunction. [[Cytokines]] TNFα, IL-1β, IL-6 released in a large scale inflammatory response results in massive [[vasodilation]], increased [[capillary]] permeability, decreased systemic vascular resistance, and [[hypotension]]. Hypotension reduces tissue perfusion pressure and thus tissue [[Hypoxia (medical)|hypoxia]] ensues. Finally, in an attempt to offset decreased [[blood pressure]], [[ventricular]] dilatation and [[myocardium|myocardial]] dysfunction will occur. | ||
==See also== | |||
*[[Anaphylactic shock]] | |||
*[[Cardiogenic shock]] | |||
*[[Neurogenic shock]] | |||
*[[Sepsis]] | |||
*[[Shock (medical)|Shock]] | |||
* [[Septic shock]] | |||
*[[Systemic inflammatory response syndrome]] (SIRS) | |||
[[Category:Medical emergencies]] | |||
[[Category:Intensive care medicine]] | |||
[[Category:Causes of death]] | |||
[[Category:Infectious disease]] | |||
[[Category:Emergency medicine]] | |||
{{ | ==References== | ||
{{reflist|2}} | |||
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{{WikiDoc Sources | |||
Revision as of 02:09, 17 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
A subclass of distributive shock, shock refers specifically to decreased tissue perfusion resulting in end-organ dysfunction. Cytokines TNFα, IL-1β, IL-6 released in a large scale inflammatory response results in massive vasodilation, increased capillary permeability, decreased systemic vascular resistance, and hypotension. Hypotension reduces tissue perfusion pressure and thus tissue hypoxia ensues. Finally, in an attempt to offset decreased blood pressure, ventricular dilatation and myocardial dysfunction will occur.
See also
- Anaphylactic shock
- Cardiogenic shock
- Neurogenic shock
- Sepsis
- Shock
- Septic shock
- Systemic inflammatory response syndrome (SIRS)
References
{{WikiDoc Sources