Seminoma causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Seminoma}} | {{Seminoma}} | ||
{{AE}}{{ | {{CMG}}; {{AE}} {{S.G.}} | ||
==Overview== | ==Overview== | ||
Common causes of seminoma include: [[cryptorchidism]], undeescending [[testis]], [[abdominal]] [[testis]], [[trauma]], [[mumps]], [[maternal]] [[estrogen]] [[Exposure (photography)|exposure]].Seminoma is caused by a [[mutation]] in the KIT [[gene]]. 12p11.2-p12.1 [[chromosomal]] [[Amplification|amplifications]] and [[Deletion (genetics)|deletions]] observed in majority of cases of seminoma. | |||
==Causes== | ==Causes== | ||
===Common Causes=== | |||
* | Common causes of seminoma may include:<ref name="pmid23519268">{{cite journal |vauthors=Ferguson L, Agoulnik AI |title=Testicular cancer and cryptorchidism |journal=Front Endocrinol (Lausanne) |volume=4 |issue= |pages=32 |date=2013 |pmid=23519268 |doi=10.3389/fendo.2013.00032 |url=}}</ref><ref name="pmid11061944">{{cite journal |vauthors=Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH |title=Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma? |journal=J. Urol. |volume=164 |issue=6 |pages=2143–4 |date=December 2000 |pmid=11061944 |doi= |url=}}</ref> | ||
*[[Cryptorchidism]] | |||
*Undescended [[testis]] | |||
*[[Abdominal]] [[testis]] | |||
*[[Trauma]] | |||
*[[Mumps]] | |||
*[[Maternal]] [[estrogen]] [[Exposure (photography)|exposure]] | |||
===Genetic Causes=== | |||
*Seminoma is caused by a [[mutation]] in the KIT [[gene]].<ref name="pmid17943970">{{cite journal |vauthors=Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA |title=Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature |journal=Genes Chromosomes Cancer |volume=47 |issue=1 |pages=34–42 |date=January 2008 |pmid=17943970 |doi=10.1002/gcc.20503 |url=}}</ref> | |||
*12p11.2-p12.1 [[chromosomal]] [[Amplification|amplifications]] and [[Deletion (genetics)|deletions]] observed in majority of cases.<ref name="pmid27584029">{{cite journal |vauthors=Woldu SL, Amatruda JF, Bagrodia A |title=Testicular germ cell tumor genomics |journal=Curr Opin Urol |volume=27 |issue=1 |pages=41–47 |date=January 2017 |pmid=27584029 |pmc=6368344 |doi=10.1097/MOU.0000000000000347 |url=}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 13:19, 15 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Common causes of seminoma include: cryptorchidism, undeescending testis, abdominal testis, trauma, mumps, maternal estrogen exposure.Seminoma is caused by a mutation in the KIT gene. 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases of seminoma.
Causes
Common Causes
Common causes of seminoma may include:[1][2]
Genetic Causes
- Seminoma is caused by a mutation in the KIT gene.[3]
- 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.[4]
References
- ↑ Ferguson L, Agoulnik AI (2013). "Testicular cancer and cryptorchidism". Front Endocrinol (Lausanne). 4: 32. doi:10.3389/fendo.2013.00032. PMID 23519268.
- ↑ Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH (December 2000). "Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma?". J. Urol. 164 (6): 2143–4. PMID 11061944.
- ↑ Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA (January 2008). "Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature". Genes Chromosomes Cancer. 47 (1): 34–42. doi:10.1002/gcc.20503. PMID 17943970.
- ↑ Woldu SL, Amatruda JF, Bagrodia A (January 2017). "Testicular germ cell tumor genomics". Curr Opin Urol. 27 (1): 41–47. doi:10.1097/MOU.0000000000000347. PMC 6368344. PMID 27584029.