Sarcoidosis causes: Difference between revisions

Jump to navigation Jump to search
Line 7: Line 7:


'''Immunological factors'''- The sarcoid granulomas indicate cell mediated immune response. Anergy to common skin test antigens like Candida and Tuberculosis purified protein derivative (PPD) is seen in sarcoidosis patient.It was demonstrated that the mycobacterial virulence factors, ESAT-6 and katG, when presented by DRB1*1101 are recognized by sarcoidosis CD4+ T cells.<ref name="pmid19536643">{{cite journal| author=Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sidney J, Sette A et al.| title=Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101. | journal=J Clin Immunol | year= 2010 | volume= 30 | issue= 1 | pages= 157-66 | pmid=19536643 | doi=10.1007/s10875-009-9311-y | pmc=PMC2821522 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19536643  }} </ref>
'''Immunological factors'''- The sarcoid granulomas indicate cell mediated immune response. Anergy to common skin test antigens like Candida and Tuberculosis purified protein derivative (PPD) is seen in sarcoidosis patient.It was demonstrated that the mycobacterial virulence factors, ESAT-6 and katG, when presented by DRB1*1101 are recognized by sarcoidosis CD4+ T cells.<ref name="pmid19536643">{{cite journal| author=Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sidney J, Sette A et al.| title=Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101. | journal=J Clin Immunol | year= 2010 | volume= 30 | issue= 1 | pages= 157-66 | pmid=19536643 | doi=10.1007/s10875-009-9311-y | pmc=PMC2821522 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19536643  }} </ref>
'''Drug side effect'''
* [[Certolizumab pegol]]
   
   
'''Environmental factors ''' - Several environmental exposures are believed to be associated with the risk for sarcoidosis:mold or mildew, musty odors at work, agricultural employment, and pesticide-using industries.
'''Environmental factors ''' - Several environmental exposures are believed to be associated with the risk for sarcoidosis:mold or mildew, musty odors at work, agricultural employment, and pesticide-using industries.

Revision as of 21:36, 27 April 2015

Sarcoidosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Sarcoidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Sarcoidosis causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Sarcoidosis causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Sarcoidosis causes

CDC on Sarcoidosis causes

Sarcoidosis causes in the news

Blogs on Sarcoidosis causes

Directions to Hospitals Treating Sarcoidosis

Risk calculators and risk factors for Sarcoidosis causes

Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.

Causes

Sarcoidosis involves a dysregulated immune response to environmental agents in a genetically susceptible host.

Immunological factors- The sarcoid granulomas indicate cell mediated immune response. Anergy to common skin test antigens like Candida and Tuberculosis purified protein derivative (PPD) is seen in sarcoidosis patient.It was demonstrated that the mycobacterial virulence factors, ESAT-6 and katG, when presented by DRB1*1101 are recognized by sarcoidosis CD4+ T cells.[1]

Drug side effect

Environmental factors - Several environmental exposures are believed to be associated with the risk for sarcoidosis:mold or mildew, musty odors at work, agricultural employment, and pesticide-using industries.

Genetic factors - Recent pangenomic studies highlight some regions of the genome such as 6p21 where are located important immune genes: MHC, BTNL2 and TNF-α . Sarcoidosis is more common and severe in blacks than whites.[2]It was recently found that non-synonymous single-nucleotide polymorphism (SNP), rs1049550, within the annexin A11 (ANXA11) gene was associated with susceptibility to sarcoidosis[3].Sarcoidosis likely results from an interplay of environmental and genetic factors.

References

  1. Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sidney J, Sette A; et al. (2010). "Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101". J Clin Immunol. 30 (1): 157–66. doi:10.1007/s10875-009-9311-y. PMC 2821522. PMID 19536643.
  2. Judson MA, Boan AD, Lackland DT (2012). "The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States". Sarcoidosis Vasc Diffuse Lung Dis. 29 (2): 119–27. PMID 23461074.
  3. Levin AM, Iannuzzi MC, Montgomery CG, Trudeau S, Datta I, McKeigue P; et al. (2013). "Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans". Genes Immun. 14 (1): 13–8. doi:10.1038/gene.2012.48. PMC 3595044. PMID 23151485.

Template:WH Template:WS