Sandbox g56
- Staphylococcus haemolyticus
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- Preferred regimen (1): Nafcillin 1–2 g IV q4-6h (maximum 12 g/day)
- Preferred regimen (2): Oxacillin 1–2 g IVq4-6h (maximum 12 g/day)
- Preferred regimen (3): Cefazolin 0.5–2 g IV q6-8h
- Alternative regimen (1): TMP-SMX 4–5 mg/kg IV q6–12h
- Alternative regimen (2): Doxycycline 100–200 mg IV q12-24h
- 2. Methicillin-resistant, Glycopeptide-susceptible strain
- Preferred regimen: Vancomycin 15–20 mg/kg IV q8–12h
- 3. Methicillin-resistant, Glycopeptide-resistant strain
- Preferred regimen (1): Daptomycin 4–6 mg/kg IV q24h
- Preferred regimen (2): Linezolid 600 mg PO/IV q12h
- Staphylococcus saprophyticus
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- 1. Urinary tract infections[3]
- Preferred regimen (1): Cephalexin 500 mg PO qid
- Preferred regimen (2): Amoxicillin-Clavulanate 875/125 mg PO bid
- Preferred regimen (3): TMP-SMX 160–800 mg PO bid
- Alternative regimen: Levofloxacin 500 mg PO qd
- Streptococcus anginosus
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- 1. Dental abscess[4]
- Preferred regimen: Penicillin V 500 mg PO qid
- Alternative regimen: Vancomycin 15–20 mg/kg IV q8–12h
- 2. Brain abscess
- Preferred regimen (1): Penicillin G 18–24 MU/day IV q4–6h
- Preferred regimen (2): Ceftriaxone 2 g IV q12h
- Alternative regimen: Vancomycin 15–20 mg/kg IV q8–12h
- Bacillus cereus
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- 1. Food poisoning[5]
- Preferred regimen: Food poisoning is usually self-limited and requires no antibiotic therapy.
- 2. Bacteremia
- Preferred regimen: Vancomycin 15 mg/kg IV q12h
- Alternative regimen: Clindamycin 600 mg IV q8h
- Note (1): Bacillus cereus is commonly resistant to beta-lactams.
- Note (2): Pseudobacteremia is transient and usually results from contaminated blood cultures, gloves, or syringes.
- 3. Meningitis or brain abscess
- Preferred regimen: Vancomycin 15 mg/kg IV q12h
- Alternative regimen: Clindamycin 600 mg IV q8h
- Note: Blood culture isolates are mostly contaminates until proven otherwise, especially in intravenous drug user population.
- 4. Endophthalmitis
- Preferred regimen: Clindamycin 450 μg intravitreal AND Gentamicin 400 μg intravitreal OR Dexamethasone intravitreal AND Vancomycin 15 mg/kg IV q12h
- Alternative regimen: Clindamycin 600 mg IV q8h
- Note: Ophthalmological consultation, culture ocular fluids, early vitrectomy, and intravitreal antibiotics are necessary.
- 5. Endocarditis
- Preferred regimen: Vancomycin 15 mg/kg IV q12h
- Note: Most blood cultures in intravenous drug users are contaminates or represent transient bacteremia.
- 6. Soft tissue infection
- Preferred regimen: Vancomycin 15 mg/kg IV q12h
- Alternative regimen: Clindamycin 600 mg IV q8h
- 7. Pneumonia
- Preferred regimen: Vancomycin 15 mg/kg IV q12h
- Alternative regimen: Clindamycin 600 mg IV q8h
- Elizabethkingia meningoseptica
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- Preferred regimen (1): Levofloxacin 750 mg IV/PO q24h
- Preferred regimen (2): TMP-SMX 8–10 mg/kg/day IV divided q6–8h
- Alternative regimen (1): Ciprofloxacin 400 mg IV q12h
- Alternative regimen (2): TMP-SMX 8–10 mg/kg/day IV divided q6–8h
References
- ↑ Abramowicz, Mark (2011). Handbook of antimicrobial therapy : selected articles from Treatment guidelines with updates from The medical letter. New Rochelle, N.Y: The Medical Letter. ISBN 978-0981527826.
- ↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.
- ↑ Abramowicz, Mark (2011). Handbook of antimicrobial therapy : selected articles from Treatment guidelines with updates from The medical letter. New Rochelle, N.Y: The Medical Letter. ISBN 978-0981527826.
- ↑ Abramowicz, Mark (2011). Handbook of antimicrobial therapy : selected articles from Treatment guidelines with updates from The medical letter. New Rochelle, N.Y: The Medical Letter. ISBN 978-0981527826.
- ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.
- ↑ Hsu, M.-S.; Liao, C.-H.; Huang, Y.-T.; Liu, C.-Y.; Yang, C.-J.; Kao, K.-L.; Hsueh, P.-R. (2011-10). "Clinical features, antimicrobial susceptibilities, and outcomes of Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) bacteremia at a medical center in Taiwan, 1999-2006". European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology. 30 (10): 1271–1278. doi:10.1007/s10096-011-1223-0. ISSN 1435-4373. PMID 21461847. Check date values in:
|date=(help) - ↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.