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• Mycoplasma pneumoniae Return to Top

• Mycoplasma pneumoniae

• 1. Community-acquired pneumonia

• Preferred regimen: Macrolide OR Tetracycline
• Alternative regimen: Fluoroquinolone

• 2. Outpatient treatment
• 2.1 Previously healthy and no risk factors for drug-resistant Streptococcus pneumoniae infection:

• Preferred regimen:Macrolides (azithromycin, clarithromycin, OR erythromycin) (strong recommendation)
• Alternative regimen: Doxycycline
• 2.2 Preferred regimen in presence of comorbidities, such as chronic heart, lung, liver, or renal disease; diabetes mellitus; alcoholism; malignancies; asplenia; immunosuppressing conditions or use of immunosuppressing drugs; use of antimicrobials within the previous 3 months or other risks for drug resistant Streptococcus pneumoniae infection: Option A Fluoroquinolone (moxifloxacin, gemifloxacin, OR levofloxacin Option B beta-lactam AND a macrolide
• 2.3 Preferred regimen in regions with a high rate of infection macrolide resistant S. pneumoniae: Fluoroquinolone (moxifloxacin, gemifloxacin, OR levofloxacin and beta-lactam AND a macrolide

• 3. Inpatient non Intensive care unit treatment

• Preferred regimen:fluoroquinolone
• Preferred regimen in level one evidence: beta-lactamANDmacrolide(Preferred beta-lactam agents include cefotaxime, ceftriaxone, and ampicillin; ertapenem for selected patients