Sandbox:Sahar

Recomendacations	Class	Level	References
History and clinical assessment
In all patients with suspected AAS, pre-test probability assessment is recommended, according to the patient’s condition, symptoms, and clinical features.
Laboratory testing
In case of suspicion of AAS, the interpretation of biomarkers should always be considered along with the pretest clinical probability.
In case of low clinical probability of AAS, negative D-dimer levels should be considered as ruling out the diagnosis.
In case of intermediate clinical probability of AAS with a positive (point-of-care) D-dimer test, further imaging tests should be considered.
In patients with high probability (risk score 2 or 3) of AD, testing of D-dimers is not recommended.
Imaging
TTE is recommended as an initial imaging investigation.
In unstabled patients with a suspicion of AAS, the following imaging modalities are recommended according to local availability and expertise:
TOE
CT
In stable patients with a suspicion of AAS, the following imaging modalities are recommended (or should be considered) according to local availability and expertise:
CT
MRI
TOE