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{{CMG}}; {{AE}}{{RAK}}


==Overview==
Cardiac surgery<ref name="pmid23447502">{{cite journal| author=Aya HD, Cecconi M, Hamilton M, Rhodes A| title=Goal-directed therapy in cardiac surgery: a systematic review and meta-analysis. | journal=Br J Anaesth | year= 2013 | volume= 110 | issue= 4 | pages= 510-7 | pmid=23447502 | doi=10.1093/bja/aet020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23447502 }} </ref>
Protein S deficiency is an autosomal dominant thrombophilia, which leads to an increased risk of thromboembolic events. Protein S is a
 
==Historical Perspective==
Protein S was first discovered and purified in Seattle, Washington in 1979, and it was arbitrarily named protein S after the city it was discovered in. At the time, the function of this protein was still unknown; however, it was hypothesized that protein S plays a role in activating protein C. Protein S deficiency was first discovered in 1984 when two related individuals with recurrent thromboembolic events and normal coagulation tests were studied. These individuals were found to have diminished anticoagulation activity, and when purified human protein S was added to their plasma, effective anticoagulation was restored.
==Classification==
 
==Pathophysiology==
 
==Clinical Features==
 
==Differentiating [disease name] from other Diseases==
 
   
==Epidemiology and Demographics==
 
===Age===
 
===Gender===
===Race===
 
==Risk Factors==
== Natural History, Complications and Prognosis==
 
== Diagnosis ==
 
===Diagnostic Criteria===
=== Symptoms ===
 
=== Physical Examination ===
 
 
=== Laboratory Findings ===
 
===Imaging Findings===
 
=== Other Diagnostic Studies ===
 
== Treatment ==
=== Medical Therapy ===
 
=== Surgery ===
 
=== Prevention ===
 
==References==
{{Reflist|2}}

Latest revision as of 15:09, 26 March 2021


Cardiac surgery[1]

  1. Aya HD, Cecconi M, Hamilton M, Rhodes A (2013). "Goal-directed therapy in cardiac surgery: a systematic review and meta-analysis". Br J Anaesth. 110 (4): 510–7. doi:10.1093/bja/aet020. PMID 23447502.