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| <ref name="pmid23115205">{{cite journal |vauthors=Hu J, Van Valckenborgh E, Menu E, De Bruyne E, Vanderkerken K |title=Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models |journal=Dis Model Mech |volume=5 |issue=6 |pages=763–71 |date=November 2012 |pmid=23115205 |pmc=3484859 |doi=10.1242/dmm.008961 |url=}}</ref><ref name="pmid6380395">{{cite journal |vauthors=Biemer JJ |title=Hepatic manifestations of lymphomas |journal=Ann. Clin. Lab. Sci. |volume=14 |issue=4 |pages=252–60 |date=1984 |pmid=6380395 |doi= |url=}}</ref>
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| {{familytree/start |summary=Weight loss Management Algorithm.}}
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| {{familytree | | | | | | | | | | M01 | | | | | | | M01=<div style="float: left; text-align: left; width: 20em; padding:1em;">'''[[Physical exam]]'''<div class="mw-collapsible mw-collapsed"><br>
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| ❑ Appearance of the [[patient]]:<br>[[Cachexia]] is observed among [[patients]] with [[malignancy]]. Surgical scar marks demonstrating previous surgery for intentional weight loss or [[malignancy]] treatment<br>
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| ❑ [[Vital signs]]<br>
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| :❑ [[Temperature]]: Chronic low-grade fever may demonstrate chronic [[infection]] , [[malignancy]]. <br>
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| :❑ [[Heart rate]]: [[Tachycardia]] with regular pulse may demonstrate [[infection]]. <br>
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| :❑ [[Respiratory rate]]: [[Tachypnea]] may demonstrate [[respiratory system]] involvement ([[infection]]\ [[metastasis]]).<br>
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| :❑ [[Blood pressure]]: [[Chronic hypertension]] or [[hypotension]] is common among elders.<br>
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| :❑ [[Oxygen saturation]]: Low saturation may demonstrate [[respiratory system]] involvement or hematologic [[malignancies]], such as [[multiple myeloma]].<br>
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| ❑ [[BMI]] assessment or simply [[weight]] among immobile or bed-ridden [[patients]].<br>
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| ❑ HEENT<br>
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| ❑ [[Cardiovascular examination]]<br>
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| ❑ [[Respiratory examination]]<br>
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| ❑ [[Gastrointestinal system]] exam includes [[oral examination]], [[abdominal examination]], and [[digital rectal exam]]. <br>
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| :❑ [[Organomegaly]]) may demonstrate [[mtastasis|metastases]] or primary lesions such as [[hepatosplenomegaly]] in [[infectious mononucleosis|IM]], [[Hodgkin's lymphoma]]. [[hepatomegaly]] is more common in [[non-Hodgkin's lymphoma]].<br>
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| ❑ Observing the [[patient]] having a meal may demonstrate<br>
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| :❑ Distractions by external stimuli may demonstrate [[dementia]]. <br>
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| :❑ Inadequate movements of the [[patient]] to feed him/herself may demonstrate [[neuromuscular]] disorders or functional limitations. <br>
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| ❑ Mini mental state examination to assess the [[cognitive function]], and [[mood]] assessment.}}
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| {{familytree | | | | | | | | | | |!| | | | | | |}}
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| {{familytree | | | | | | | | | | U01 | | | | | | | U01='''Labs'''<div class="mw-collapsible mw-collapsed"><div style="float: left; text-align: left; width: 20em; padding:1em;">
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| ❑ [[CBC]] with differential<br>
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| ❑ [[ESR]]<br>
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| ❑ [[CMP]]<br>
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| ❑ [[Peripheral smaer]]<br>
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| ❑ [[Liver function tests|LFTs]]<br>
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| *''Labs may be required at a later stage pf diagnosis''}}
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| {{familytree | | | | | | | | | | |!| | | | | | |}}
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| {{familytree | | | | | | | | | | | | | | | | | |}}
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| {{familytree | | | | | | | | | | | | | | | | | |}}
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| {{familytree/end}}
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