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The following table contains the main risk factors for CDI:[1][2][3][2][2]

Severity of the disease
Mild: diarrhea as the only symptom
Moderate: raised white cell count but <15,000 cells/mL and serum creatine <1.5 times baseline
Severe: leucocytosis >15,000 cells/mL OR serum creatinene level >1.5 times baseline or abdominal tenderness and serum albumin < 3 g/dL
Severe complicated: hypotension or shock, ileus, megacolon, leucocytosis >20,000 cells/mL OR leucopenia <2,000, lactate >2.2 mmol/L, delirium, fever ≥ 38.5 °C, organ failure


Community-onset infection Hospital-onset infection
Includes patients with 1 or more of the following conditions:
  • The presence of an invasive device at time of admission
  • History of MRSA infection or colonization
  • History of surgery, hospitalization, dialysis, or residence in a long-term care facility in the previous 12 months.
Includes patients with positive culture results obtained >48 h after admission.
Patients might also have 1 of the conditions described in community-onset infection.
  1. Hensgens MP, Goorhuis A, Dekkers OM, Kuijper EJ (2012). "Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics". J Antimicrob Chemother. 67 (3): 742–8. doi:10.1093/jac/dkr508. PMID 22146873.
  2. 2.0 2.1 2.2 Knight, Christopher L.; Surawicz, Christina M. (2013). "Clostridium difficile Infection". Medical Clinics of North America. 97 (4): 523–536. doi:10.1016/j.mcna.2013.02.003. ISSN 0025-7125.
  3. Planche, Tim (2013). "Clostridium difficile". Medicine. 41 (11): 654–657. doi:10.1016/j.mpmed.2013.08.003. ISSN 1357-3039.