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▸ Click on the following categories to expand treatment regimens.

Conjunctivitis Medical Therapy

  ▸  Bacterial Conjunctivitis

  ▸  Gram-Positive (Cocco-)Bacilli

Gram-Negative

  ▸  Gram-Negative Cocci in Pairs

  ▸  Gram-Negative Coccobacilli

  ▸  Gram-Negative Bacilli

Bacterial Conjunctivitis
Preferred Regimen
Non-gonococcal
Ciprofloxacin 1–2 gtts q2h while awake x 1st 2 days, then q4–8h x 7 days
OR
Gatifloxacin 1–2 gtts q2h while awake x 1st 2 days, then q4–8h x 7 days
OR
Levofloxacin 1–2 gtts q2h while awake x 1st 2 days, then q4–8h x 7 days
OR
Moxifloxacin 1–2 gtts q2h while awake x 1st 2 days, then q4–8h x 7 days
Gonococcal
Adult dose
Ciprofloxacin 1 gm IM/IV as 1 dose
Pediatric dose
Ciprofloxacin 25-50 mg/kg IV/IM (not to exceed 125 mg) as 1 dose
Alternative Regimen (for non-gonococcal only)
Polymyxin B + Trimethoprim 1–2 gtts q3–6h x 7–10 days
OR
Azithromycin 1%, 1 gtt bid x 2 days, then 1 gtt daily x 5 days
Chlamydia Trachomatis
Preferred Regimen
Azithromycin 1 gm once or twice weekly
Alternative Regimen
Doxycycline 100 mg bid po x 7 days
Gram-Positive (Cocco-)Bacilli
Preferred Regimen
Ampicillin 2 g IV q4h
OR
Penicillin G 4 MU IV q4h
PLUS
Gentamicin 1.7 mg/kg IV q8h
Alternative Regimen
TMP/SMZ 5 mg/kg IV q6—12h (TMP component)
OR
Meropenem 2 g IV q8h
Gram-Negative Cocci in Pairs
Preferred Regimen
Cefotaxime 2 g IV q4—6h
OR
Ceftriaxone 2 g IV q12h
Alternative Regimen
Penicillin G 4 MU IV q4h
OR
Ampicillin 2 g IV q4h
OR
Chloramphenicol 1—1.5 g IV q6h
OR
Moxifloxacin 400 mg IV q24h
OR
Aztreonam 2 g IV q6—8h
Gram-Negative Coccobacilli
Preferred Regimen
Cefotaxime 2 g IV q4—6h
OR
Ceftriaxone 2 g IV q12h
Alternative Regimen
Chloramphenicol 1—1.5 g IV q6h
OR
Cefepime 2 g IV q8h
OR
Meropenem 2 g IV q8h
OR
Moxifloxacin 400 mg IV q24h
Gram-Negative Bacilli
Preferred Regimen
Cefotaxime 2 g IV q4—6h
OR
Ceftriaxone 2 g IV q12h
Alternative Regimen
Cefepime 2 g IV q8h
OR
Meropenem 2 g IV q8h
OR
Aztreonam 2 g IV q6—8h
OR
Moxifloxacin 400 mg IV q24h
OR
TMP/SMZ 5 mg/kg IV q6—12h (TMP component)