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{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase SIK2''' is an [[enzyme]] that in humans is encoded by the ''SIK2'' [[gene]].<ref name="pmid15067358">{{cite journal | vauthors = Katoh M, Katoh M | title = Identification and characterization of human FOXN5 and rat Foxn5 genes in silico | journal = International Journal of Oncology | volume = 24 | issue = 5 | pages = 1339–44 | date = May 2004 | pmid = 15067358 | pmc = | doi = 10.3892/ijo.24.5.1339 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNF1LK2 SNF1-like kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23235| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = SNF1-like kinase 2
| HGNCid = 21680
| Symbol = SNF1LK2
| AltSymbols =; DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; SIK2
| OMIM = 608973
| ECnumber = 
| Homologene = 22875
| MGIid = 2445031
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0046626 |text = regulation of insulin receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23235
    | Hs_Ensembl = ENSG00000170145
    | Hs_RefseqProtein = NP_056006
    | Hs_RefseqmRNA = NM_015191
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 110978380
    | Hs_GenLoc_end = 111102840
    | Hs_Uniprot = Q9H0K1
    | Mm_EntrezGene = 235344
    | Mm_Ensembl = ENSMUSG00000037112
    | Mm_RefseqmRNA = NM_178710
    | Mm_RefseqProtein = NP_848825
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 50645029
    | Mm_GenLoc_end = 50761303
    | Mm_Uniprot = Q8BLX0
  }}
}}
'''SNF1-like kinase 2''', also known as '''SNF1LK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNF1LK2 SNF1-like kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23235| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SNF1LK2 has been shown to [[Protein-protein interaction|interact]] with [[CRTC2]].<ref name=pmid15454081>{{cite journal | vauthors = Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M | title = The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector | journal = Cell | volume = 119 | issue = 1 | pages = 61–74 | date = Oct 2004 | pmid = 15454081 | doi = 10.1016/j.cell.2004.09.015 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 5 | pages = 277–86 | date = Oct 1998 | pmid = 9872452 | doi = 10.1093/dnares/5.5.277 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi= }}
* {{cite journal | vauthors = Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M | title = Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 18440–7 | date = May 2003 | pmid = 12624099 | doi = 10.1074/jbc.M211770200 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Katoh M, Katoh M | title = Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats | journal = International Journal of Oncology | volume = 23 | issue = 5 | pages = 1471–6 | date = Nov 2003 | pmid = 14532992 | doi = 10.3892/ijo.23.5.1471 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR | title = LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 | journal = The EMBO Journal | volume = 23 | issue = 4 | pages = 833–43 | date = Feb 2004 | pmid = 14976552 | pmc = 381014 | doi = 10.1038/sj.emboj.7600110 }}
*{{cite journal  | author=Horike N, Takemori H, Katoh Y, ''et al.'' |title=Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18440-7 |year= 2003 |pmid= 12624099 |doi= 10.1074/jbc.M211770200 }}
* {{cite journal | vauthors = Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M | title = The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector | journal = Cell | volume = 119 | issue = 1 | pages = 61–74 | date = Oct 2004 | pmid = 15454081 | doi = 10.1016/j.cell.2004.09.015 }}
*{{cite journal | author=Katoh M, Katoh M |title=Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. |journal=Int. J. Oncol. |volume=23 |issue= 5 |pages= 1471-6 |year= 2004 |pmid= 14532992 |doi= }}
* {{cite journal | vauthors = Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M | title = Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm | journal = European Journal of Biochemistry / FEBS | volume = 271 | issue = 21 | pages = 4307–19 | date = Nov 2004 | pmid = 15511237 | doi = 10.1111/j.1432-1033.2004.04372.x }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Lizcano JM, Göransson O, Toth R, ''et al.'' |title=LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. |journal=EMBO J. |volume=23 |issue= 4 |pages= 833-43 |year= 2005 |pmid= 14976552 |doi= 10.1038/sj.emboj.7600110 }}
*{{cite journal | author=Katoh M, Katoh M |title=Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. |journal=Int. J. Oncol. |volume=24 |issue= 5 |pages= 1339-44 |year= 2004 |pmid= 15067358 |doi=  }}
*{{cite journal  | author=Screaton RA, Conkright MD, Katoh Y, ''et al.'' |title=The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. |journal=Cell |volume=119 |issue= 1 |pages= 61-74 |year= 2004 |pmid= 15454081 |doi= 10.1016/j.cell.2004.09.015 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Katoh Y, Takemori H, Min L, ''et al.'' |title=Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm. |journal=Eur. J. Biochem. |volume=271 |issue= 21 |pages= 4307-19 |year= 2004 |pmid= 15511237 |doi= 10.1111/j.1432-1033.2004.04372.x }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Serine/threonine-specific protein kinases}}
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[[Category:EC 2.7.11]]

Latest revision as of 02:34, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.[1][2]

Interactions

SNF1LK2 has been shown to interact with CRTC2.[3]

References

  1. ↑ Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". International Journal of Oncology. 24 (5): 1339–44. doi:10.3892/ijo.24.5.1339. PMID 15067358.
  2. ↑ "Entrez Gene: SNF1LK2 SNF1-like kinase 2".
  3. ↑ Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M (May 2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2". The Journal of Biological Chemistry. 278 (20): 18440–7. doi:10.1074/jbc.M211770200. PMID 12624099.
  • Katoh M, Katoh M (Nov 2003). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats". International Journal of Oncology. 23 (5): 1471–6. doi:10.3892/ijo.23.5.1471. PMID 14532992.
  • Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
  • Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
  • Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M (Nov 2004). "Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm". European Journal of Biochemistry / FEBS. 271 (21): 4307–19. doi:10.1111/j.1432-1033.2004.04372.x. PMID 15511237.


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