SIVA1
| SIVA1, apoptosis-inducing factor | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SIVA1 ; CD27BP; SIVA; Siva-1; Siva-2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4692 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SIVA1 203489 at tn.png | |||||||||||
| File:PBB GE SIVA1 210792 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
SIVA1, apoptosis-inducing factor, also known as SIVA1, is a human gene.[1]
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.[1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Prasad KV, Ao Z, Yoon Y; et al. (1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6346–51. PMID 9177220.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Henke A, Launhardt H, Klement K; et al. (2000). "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva". J. Virol. 74 (9): 4284–90. PMID 10756043.
- Cao C, Ren X, Kharbanda S; et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". J. Biol. Chem. 276 (15): 11465–8. doi:10.1074/jbc.C100050200. PMID 11278261.
- Henke A, Nestler M, Strunze S; et al. (2001). "The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva". Virology. 289 (1): 15–22. doi:10.1006/viro.2001.1082. PMID 11601913.
- Held-Feindt J, Mentlein R (2002). "CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors". Int. J. Cancer. 98 (3): 352–6. PMID 11920585.
- Xue L, Chu F, Cheng Y; et al. (2002). "Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6925–30. doi:10.1073/pnas.102182299. PMID 12011449.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Spinicelli S, Nocentini G, Ronchetti S; et al. (2003). "GITR interacts with the pro-apoptotic protein Siva and induces apoptosis". Cell Death Differ. 9 (12): 1382–4. doi:10.1038/sj.cdd.4401140. PMID 12478477.
- Chu F, Borthakur A, Sun X; et al. (2004). "The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis". Apoptosis. 9 (1): 83–95. doi:10.1023/B:APPT.0000012125.01799.4c. PMID 14739602.
- Py B, Slomianny C, Auberger P; et al. (2004). "Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway". J. Immunol. 172 (7): 4008–17. PMID 15034012.
- Fortin A, MacLaurin JG, Arbour N; et al. (2004). "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. doi:10.1074/jbc.M400376200. PMID 15105421.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Chu F, Barkinge J, Hawkins S; et al. (2005). "Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2". Cancer Res. 65 (12): 5301–9. doi:10.1158/0008-5472.CAN-04-3270. PMID 15958577.
- Gudi R, Barkinge J, Hawkins S; et al. (2006). "Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD)". Oncogene. 25 (24): 3458–62. doi:10.1038/sj.onc.1209381. PMID 16491128.
- Nestler M, Martin U, Hortschansky P; et al. (2006). "The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22". Mol. Cell. Biochem. 287 (1–2): 147–55. doi:10.1007/s11010-005-9082-6. PMID 16683188.
- Severino A, Abbruzzese C, Manente L; et al. (2007). "Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytes". J. Cell. Physiol. 212 (1): 118–25. doi:10.1002/jcp.21011. PMID 17348035.
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