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The red to purple, spotted ([[petechial]]) rash of RMSF is usually not seen until the sixth day or later after onset of symptoms and occurs in 35-60% of patients with the [[infection]]. This is a sign of progression to severe disease, and every attempt should be made to begin treatment before petechiae develop.
The red to purple, spotted ([[petechial]]) rash of RMSF is usually not seen until the sixth day or later after onset of symptoms and occurs in 35-60% of patients with the [[infection]]. This is a sign of progression to severe disease, and every attempt should be made to begin treatment before petechiae develop.


[[Image:RMSF rash 1.jpg|Early stage rash in a patient with RMSF]]
<gallery perRow="3">
[[Image:RMSF rash 2.jpg|Early stage rash in a patient with RMSF]]
Image:RMSF rash 1.jpg|Early stage rash in a patient with RMSF
[[Image:RMSF rash 3.jpg|Later stage rash in a patient with RMSF]]
Image:RMSF rash 2.jpg|Early stage rash in a patient with RMSF
[[Image:RMSF rash 4.jpg|Rocky Mountain spotted fever is a potentially fatal infection transmitted to humans by ticks. This photograph shows the classical appearing rash which often begins on the wrists and ankles, and spreads rapidly towards the center of the body. The rash may also be present on the palms and soles]]
Image:RMSF rash 3.jpg|Later stage rash in a patient with RMSF
[[Image:RMSF rash 5.jpg|Rocky Mountain Spotted Fever is a disease transmitted to humans by a tick bite.  The spots begin as flat (macular) red (erythematous) patches that may bleed into the skin, causing purplish spots (purpura).  The disease is named after its characteristic spots.]]
Image:RMSF rash 4.jpg|Rocky Mountain spotted fever is a potentially fatal infection transmitted to humans by ticks. This photograph shows the classical appearing rash which often begins on the wrists and ankles, and spreads rapidly towards the center of the body. The rash may also be present on the palms and soles
[[Image:RMSF rash 6.jpg|Rocky Mountain spotted fever is caused by the organism Rickettsia rickettsii and is transmitted by a tick bite.  It is a serious infection that produces a classical rash in about 90% of infected individuals.  This is the typical appearance of the rash.  There are many symptoms that affect the entire body (systemic)]]
Image:RMSF rash 5.jpg|Rocky Mountain Spotted Fever is a disease transmitted to humans by a tick bite.  The spots begin as flat (macular) red (erythematous) patches that may bleed into the skin, causing purplish spots (purpura).  The disease is named after its characteristic spots.
Image:RMSF rash 6.jpg|Rocky Mountain spotted fever is caused by the organism Rickettsia rickettsii and is transmitted by a tick bite.  It is a serious infection that produces a classical rash in about 90% of infected individuals.  This is the typical appearance of the rash.  There are many symptoms that affect the entire body (systemic)
</gallery>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 21:01, 14 February 2012

Rocky Mountain spotted fever Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Physician diagnosis

There are several aspects of RMSF that make it challenging for healthcare providers to diagnose and treat. The symptoms of RMSF vary from patient to patient and can easily resemble other, more common diseases. Treatment for this disease is most effective at preventing death if started in the first five days of symptoms. Diagnostic tests for this disease, especially tests based on the detection of antibodies, will frequently appear negative in the first 7-10 days of illness. Due to the complexities of this disease and the limitations of currently available diagnostic tests, there is no test available at this time that can provide a conclusive result in time to make important decisions about treatment.

For this reason, healthcare providers must use their judgment to treat patients based on clinical suspicion alone. Healthcare providers may find important information in the patient’s history and physical examination that may aid clinical suspicion. Information such as recent tick bites, exposure to high grass and tick-infested areas, contact with dogs, similar illnesses in family members or pets, or history of recent travel to areas of high incidence can be helpful in making the diagnosis. Also, information about the presence of symptoms such as fever and rash may be helpful. The healthcare provider may also look at routine blood tests, such as a complete blood cell count or a chemistry panel. Clues such as a low platelet count (thrombocytopenia), low sodium levels (hyponatremia), or elevated liver enzyme levels are often helpful predictors of RMSF but may not be present in all patients. After a suspect diagnosis is made on clinical suspicion and treatment has begun, specialized laboratory testing should be used to confirm the diagnosis of RMSF.

The diagnosis of RMSF must be made based on clinical signs and symptoms, and can later be confirmed using specialized confirmatory laboratory tests. Treatment should never be delayed pending the receipt of laboratory test results, or be withheld on the basis of an initial negative finding for R. rickettsii.

Rash

While most people with RMSF (90%) have some type of rash during the course of illness, some people do not develop the rash until late in the disease process, after treatment should have already begun. Approximately 10% of RMSF patients never develop a rash. It is important for physicians to consider RMSF if other signs and symptoms support a diagnosis, even if a rash is not present.

A classic case of RMSF involves a rash that first appears 2-5 days after the onset of fever as small, flat, pink, non-itchy spots (macules) on the wrists, forearms, and ankles and spreads to include the trunk and sometimes the palms and soles. Often the rash varies from this description and people who fail to develop a rash, or develop an atypical rash, are at increased risk of being misdiagnosed.

The red to purple, spotted (petechial) rash of RMSF is usually not seen until the sixth day or later after onset of symptoms and occurs in 35-60% of patients with the infection. This is a sign of progression to severe disease, and every attempt should be made to begin treatment before petechiae develop.

References