Rnd1

Rho family GTPase 1
File:PBB Protein RND1 image.jpg PDB rendering based on 2cls.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2cls​
Identifiers
Symbols	RND1 ; ARHS; FLJ42294; RHO6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8706
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RND1 210056 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Rnd1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.. It is encoded by the gene RND1.

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]

Further reading

• Nobes CD, Lauritzen I, Mattei MG; et al. (1998). "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion". J. Cell Biol. 141 (1): 187–97. PMID 9531558.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vayssière B, Zalcman G, Mahé Y; et al. (2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Lett. 467 (1): 91–6. PMID 10664463.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aoki J, Katoh H, Mori K, Negishi M (2001). "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells". Biochem. Biophys. Res. Commun. 278 (3): 604–8. doi:10.1006/bbrc.2000.3842. PMID 11095956.CS1 maint: Multiple names: authors list (link)
• Rohm B, Rahim B, Kleiber B; et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases". FEBS Lett. 486 (1): 68–72. PMID 11108845.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". J. Biol. Chem. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.CS1 maint: Multiple names: authors list (link)
• Katoh H, Harada A, Mori K, Negishi M (2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. PMID 11940653.CS1 maint: Multiple names: authors list (link)
• Hanzal-Bayer M, Renault L, Roversi P; et al. (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMID 11980706.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.CS1 maint: Multiple names: authors list (link)
• Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras". Science. 305 (5685): 862–5. doi:10.1126/science.1097545. PMID 15297673.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada A, Katoh H, Negishi M (2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells". J. Biol. Chem. 280 (18): 18418–24. doi:10.1074/jbc.M411356200. PMID 15738000.CS1 maint: Multiple names: authors list (link)
• Kim YS, Hori M, Yasuda K, Ozaki H (2006). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria". Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 142 (4): 410–5. doi:10.1016/j.cbpa.2005.08.028. PMID 16311049.CS1 maint: Multiple names: authors list (link)