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==Overview==
==Overview==
Rhinosinusitis is the inflammation of the nasal mucosa and paranasal sinuses. The terms [[sinusitis]] and [[rhinosinusitis]] are used interchangeably, although rhinosinusitis is preferred because inflammation of the paranasal sinuses rarely ever occurs without concurrent inflammation of the nasal mucosa. There are 4 pairs of sinus cavities, named for the [[skull]] bones they are located in: [[maxillary]], [[ethmoid]], [[frontal]] and [[sphenoidal]]. The cause of [[rhinosinusitis]] is mostly infectious, although it can be associated with other medical conditions such as [[allergies]]. The diagnosis is primarily clinical and imaging and other diagnostic studies are not necessary for diagnosis. A [[CT]] or [[MRI]] is indicated when [[rhinosinusitis]] is complicated by extension of the infection to surrounding structures, such as the [[orbit]] and [[brain]]. [[Rhinosinusitis]] is a self-limiting disease and treatment is supportive, in order to alleviate the respiratory symptoms and pain. [[Antibiotics]] may be indicated in select cases of [[acute]] [[bacterial]] and [[chronic]] rhinosinusitis. 
==Historical Perspective==
==Historical Perspective==
*Between 3700 and 1500 BC, the [[paranasal sinuses]] were first identified by the ancient Egyptians. The ancient Egyptians are considered to have been the first in discovering sinus surgery; when mummifying a human body, they would remove the [[brain]] through the nasal cavity.<ref name="pmid24386595">{{cite journal |vauthors=Mavrodi A, Paraskevas G |title=Evolution of the paranasal sinuses' anatomy through the ages |journal=Anat Cell Biol |volume=46 |issue=4 |pages=235–8 |year=2013 |pmid=24386595 |pmc=3875840 |doi=10.5115/acb.2013.46.4.235 |url=}}</ref>
*[[Hippocrates]] later described the process of producing voice as "air passing through empty cavities," which referred to the [[paranasal sinuses]]. He also documented in his writings about [[nasal polyps]] and how to remove them.<ref name="pmid24386595">{{cite journal |vauthors=Mavrodi A, Paraskevas G |title=Evolution of the paranasal sinuses' anatomy through the ages |journal=Anat Cell Biol |volume=46 |issue=4 |pages=235–8 |year=2013 |pmid=24386595 |pmc=3875840 |doi=10.5115/acb.2013.46.4.235 |url=}}</ref>
*In 1489, Leonardo Da Vinci was the first to illustrate the [[maxillary]] sinuses and their relationship with the teeth of the upper [[jaw]]. <ref name="Drawings of Leonardo">The Drawings of Leonardo http://www.drawingsofleonardo.org. Accessed on Oct. 3rd, 2016.</ref>
*In 1905, the first paper in literature was found on suppurative frontal sinusitis.<ref name="pmid20761892">{{cite journal |vauthors=Milligan W |title=SUPPURATIVE FRONTAL SINUSITIS: ITS SURGICAL TREATMENT, BASED ON AN ANALYSIS OF FORTY CASES |journal=Br Med J |volume=1 |issue=2300 |pages=171–4 |year=1905 |pmid=20761892 |pmc=2318988 |doi= |url=}}</ref>
==Classification==
==Classification==
Rhinosinusitis can be classified based on the location of sinus involved into maxillary, frontal, ethmoidal, sphenoidal or pansinusitis. It can also be classified according to the duration of the disease or etiology.<ref name="pmid27602668">{{cite journal| author=Rosenfeld RM| title=CLINICAL PRACTICE. Acute Sinusitis in Adults. | journal=N Engl J Med | year= 2016 | volume= 375 | issue= 10 | pages= 962-70 | pmid=27602668 | doi=10.1056/NEJMcp1601749 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27602668  }} </ref><ref name="mayoclinic">{{Cite journal
Rhinosinusitis can be classified based on the location of [[sinus]] involved into [[maxillary]], [[frontal]], [[ethmoidal]], [[sphenoidal]] or pansinusitis.<ref name="icd10"> World Health Organization International Classification of Disease (2016) http://apps.who.int/classifications/icd10/browse/2016/en#/J01 Accessed on September 22, 2016. </ref><ref name= "icd"> American Academy of Allergy Asthma and Immunology (2014) https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20Management/finances-coding/sinus-disease-codes-ICD10.pdf Accessed on September 22, 2016. </ref><ref name="mandelll">{{cite book |last1=Mandell |first1=Gerald |last2=Douglas |first2=R.Gordon |last3=Bennett |first3=John |date=1985 |title=Principles and Practice of Infectious Disease |location= USA |publisher=A Wiley Medical Publication |page=370 |isbn=0471876437}}</ref>. It can also be classified according to the duration of the disease or etiology.<ref name="pmid27602668">{{cite journal| author=Rosenfeld RM| title=CLINICAL PRACTICE. Acute Sinusitis in Adults. | journal=N Engl J Med | year= 2016 | volume= 375 | issue= 10 | pages= 962-70 | pmid=27602668 | doi=10.1056/NEJMcp1601749 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27602668  }} </ref><ref name="mayoclinic">{{Cite journal
  | author = [[Eli O. Meltzer]] & [[Daniel L. Hamilos]]
  | author = [[Eli O. Meltzer]] & [[Daniel L. Hamilos]]
  | title = Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines
  | title = Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines
Line 19: Line 25:
}}</ref>
}}</ref>
==Pathophysiology==
==Pathophysiology==
The pathophysiology for both acute and chronic rhinosinusitis involves blockage of the nasal sinuses and inflammation of the nasal sinuses. However, biofilms play a role in the pathogenesis of chronic rhinosinusitis. There are many associated conditions with rhinosinusitis, but most notably are those related to allergy and immunodeficiency.  
The pathophysiology for both [[acute]] and [[chronic]] rhinosinusitis involves blockage of the nasal [[sinuses]] and [[inflammation]] of the nasal [[sinuses]]. However, [[biofilms]] play a role in the pathogenesis of [[chronic]] rhinosinusitis. There are many associated conditions with rhinosinusitis, but most notably are those related to [[allergy]] and [[immunodeficiency]].  
==Causes==
==Causes==
The causes of rhinosinusitis can be divided according to the infectious group that causes it into: bacterial, viral and fungal.
The causes of rhinosinusitis can be divided according to the infectious group that causes it into: [[bacterial]], [[viral]] and [[fungal]].
==Differential Diagnosis==
==Differential Diagnosis==
Rhinosinusitis must be differentiated from other diseases that may present with a headache and/or respiratory symptoms.
Rhinosinusitis must be differentiated from other diseases that may present with a [[headache]] and/or respiratory symptoms.
==Epidemiology and Demographics==
==Epidemiology and Demographics==
The incidence of acute rhinosinusitis and prevalence of chronic rhinosinusitis have a wide range, depending on the setting.  
The incidence of [[acute]] rhinosinusitis and prevalence of [[chronic]] rhinosinusitis have a wide range, depending on the setting.  
==Risk Factors==
==Risk Factors==
Anatomical abnormalities of the nasal cavity, immunodeficiency and other diseases are all risk factors for the development of rhinosinusitis.  
Anatomical abnormalities of the [[nasal cavity]], [[immunodeficiency]] and other diseases are all risk factors for the development of rhinosinusitis.
 
==Screening==
==Screening==
There are no recommendations for screening for rhinosinusitis.<ref name="USPSTF sinusitis"> US Preventive Services Task Force (2016) https://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=rhinosinusitis Accessed on September 28, 2016.</ref>
There are no recommendations for screening for rhinosinusitis.<ref name="USPSTF sinusitis"> US Preventive Services Task Force (2016) https://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=rhinosinusitis Accessed on September 28, 2016.</ref>
==Natural History, Complications and Prognosis==
==Natural History, Complications and Prognosis==
Acute rhinosinusitis is a self-limiting disease. However, rarely acute and chronic rhinosinusitis can be complicated by extension of the infection to the surrounding structures, such as the eyes and brain.  
[[Acute]] rhinosinusitis is a self-limiting disease. However, rarely [[acute]] and [[chronic]] rhinosinusitis can be complicated by extension of the infection to the surrounding structures, such as the [[eyes]] and [[brain]].  
==History and Symptoms==
==History and Symptoms==
Rhinosinusitis can present with a wide range of constitutional and respiratory symptoms.  
Rhinosinusitis can present with a wide range of constitutional and respiratory symptoms.  
==Physical Examination==
==Physical Examination==
Examination of the nose with a speculum or otoscope may reveal mucosal edema, narrowing of the middle meatus, purulent rhinorrhea and other findings.  
Examination of the [[nose]] with a [[speculum]] or [[otoscope]] may reveal mucosal [[edema]], narrowing of the middle [[meatus]], purulent [[rhinorrhea]] and other findings.  
==Laboratory Findings==
==Laboratory Findings==
There are several lab findings that can be done when suspecting rhinosinusitis, but these findings are nonspecific.  
There are several lab findings that can be done when suspecting rhinosinusitis, but these findings are nonspecific.  
==X-Ray==
==X-Ray==
A plain [[x-ray]] of the sinuses has no role in the workup of rhinosinusitis. It may show a fluid level in the sinuses, but a plain [[x-ray]] is associated with a high negative and high positive rate for rhinosinusitis.<ref name="pmid15378314">{{cite journal |vauthors=Berger G, Steinberg DM, Popovtzer A, Ophir D |title=Endoscopy versus radiography for the diagnosis of acute bacterial rhinosinusitis |journal=Eur Arch Otorhinolaryngol |volume=262 |issue=5 |pages=416–22 |year=2005 |pmid=15378314 |doi=10.1007/s00405-004-0830-0 |url=}}</ref><ref name="pmid21490181">{{cite journal |vauthors=Meltzer EO, Hamilos DL |title=Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines |journal=Mayo Clin. Proc. |volume=86 |issue=5 |pages=427–43 |year=2011 |pmid=21490181 |pmc=3084646 |doi=10.4065/mcp.2010.0392 |url=}}</ref>
A plain [[x-ray]] of the [[sinuses]] has no role in the workup of rhinosinusitis. It may show a fluid level in the sinuses, but a plain [[x-ray]] is associated with a high negative and high positive rate for rhinosinusitis.<ref name="pmid15378314">{{cite journal |vauthors=Berger G, Steinberg DM, Popovtzer A, Ophir D |title=Endoscopy versus radiography for the diagnosis of [[acute]] bacterial rhinosinusitis |journal=Eur Arch Otorhinolaryngol |volume=262 |issue=5 |pages=416–22 |year=2005 |pmid=15378314 |doi=10.1007/s00405-004-0830-0 |url=}}</ref><ref name="pmid21490181">{{cite journal |vauthors=Meltzer EO, Hamilos DL |title=Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines |journal=Mayo Clin. Proc. |volume=86 |issue=5 |pages=427–43 |year=2011 |pmid=21490181 |pmc=3084646 |doi=10.4065/mcp.2010.0392 |url=}}</ref>
==CT==
==CT==
Although not routinely indicated for suspected cases of rhinosinusitis and findings are highly nonspecific, CT scan is the imaging modality of choice in cases of chronic or complicated rhinosinusitis. Positive CT scan findings are not essential for diagnosis, but negative CT scan findings rules out rhinosinusitis. Findings include mucosal thickening and narrowing of the osteomeatal sinuses.<ref name="pmid21490181">{{cite journal |vauthors=Meltzer EO, Hamilos DL |title=Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines |journal=Mayo Clin. Proc. |volume=86 |issue=5 |pages=427–43 |year=2011 |pmid=21490181 |pmc=3084646 |doi=10.4065/mcp.2010.0392 |url=}}</ref><ref name="pmid22438350">{{cite journal |vauthors=Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein EJ, Hicks LA, Pankey GA, Seleznick M, Volturo G, Wald ER, File TM |title=IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults |journal=Clin. Infect. Dis. |volume=54 |issue=8 |pages=e72–e112 |year=2012 |pmid=22438350 |doi=10.1093/cid/cir1043 |url=}}</ref><ref name="pmid20974374">{{cite journal |vauthors=Hoxworth JM, Glastonbury CM |title=Orbital and intracranial complications of acute sinusitis |journal=Neuroimaging Clin. N. Am. |volume=20 |issue=4 |pages=511–26 |year=2010 |pmid=20974374 |doi=10.1016/j.nic.2010.07.004 |url=}}</ref><ref name="pmid27602668">{{cite journal |vauthors=Rosenfeld RM |title=CLINICAL PRACTICE. Acute Sinusitis in Adults |journal=N. Engl. J. Med. |volume=375 |issue=10 |pages=962–70 |year=2016 |pmid=27602668 |doi=10.1056/NEJMcp1601749 |url=}}</ref>
Although not routinely indicated for suspected cases of rhinosinusitis and findings are highly nonspecific, [[CT]] scan is the imaging modality of choice in cases of [[chronic]] or complicated rhinosinusitis. Positive [[CT]] scan findings are not essential for diagnosis, but negative [[CT]] scan findings rules out rhinosinusitis. Findings include mucosal thickening and narrowing of the osteomeatal [[sinuses]].<ref name="pmid21490181">{{cite journal |vauthors=Meltzer EO, Hamilos DL |title=Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus guidelines |journal=Mayo Clin. Proc. |volume=86 |issue=5 |pages=427–43 |year=2011 |pmid=21490181 |pmc=3084646 |doi=10.4065/mcp.2010.0392 |url=}}</ref><ref name="pmid22438350">{{cite journal |vauthors=Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein EJ, Hicks LA, Pankey GA, Seleznick M, Volturo G, Wald ER, File TM |title=IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults |journal=Clin. Infect. Dis. |volume=54 |issue=8 |pages=e72–e112 |year=2012 |pmid=22438350 |doi=10.1093/cid/cir1043 |url=}}</ref><ref name="pmid20974374">{{cite journal |vauthors=Hoxworth JM, Glastonbury CM |title=Orbital and intracranial complications of acute sinusitis |journal=Neuroimaging Clin. N. Am. |volume=20 |issue=4 |pages=511–26 |year=2010 |pmid=20974374 |doi=10.1016/j.nic.2010.07.004 |url=}}</ref><ref name="pmid27602668">{{cite journal |vauthors=Rosenfeld RM |title=CLINICAL PRACTICE. Acute Sinusitis in Adults |journal=N. Engl. J. Med. |volume=375 |issue=10 |pages=962–70 |year=2016 |pmid=27602668 |doi=10.1056/NEJMcp1601749 |url=}}</ref>
==Other Imaging Findings==
==Other Imaging Findings==
[[MRI]] is an excellent alternative to [[CT]] scan in detecting [[orbital]] and [[intracranial]] complications of rhinosinusitis.<ref name="pmid17640430">{{cite journal |vauthors=McIntosh D, Mahadevan M |title=Failure of contrast enhanced computed tomography scans to identify an orbital abscess. The benefit of magnetic resonance imaging |journal=J Laryngol Otol |volume=122 |issue=6 |pages=639–40 |year=2008 |pmid=17640430 |doi=10.1017/S0022215107000102 |url=}}</ref><ref name="pmid11889374">{{cite journal |vauthors=Younis RT, Anand VK, Davidson B |title=The role of computed tomography and magnetic resonance imaging in patients with sinusitis with complications |journal=Laryngoscope |volume=112 |issue=2 |pages=224–9 |year=2002 |pmid=11889374 |doi=10.1097/00005537-200202000-00005 |url=}}</ref>
==Other Diagnostic Studies==
==Other Diagnostic Studies==
Nasal [[endoscopy]] and anterior rhinoscopy can be done in the case of rhinosinusitis to evaluate for nasal anatomy, [[nasal polyps]] and the paranasal [[sinuses]]. [[Endoscopy]] can be done as part of the functional endoscopic sinus surgery (FESS), which is used as a treatment in the case of chronic rhinosinusitis and [[nasal polyps]].<ref name="pmid27340637">{{cite journal |vauthors=K Maru Y, Gupta Y |title=Nasal Endoscopy Versus Other Diagnostic Tools in Sinonasal Diseases |journal=Indian J Otolaryngol Head Neck Surg |volume=68 |issue=2 |pages=202–6 |year=2016 |pmid=27340637 |doi=10.1007/s12070-014-0762-y |url=}}</ref><ref name="pmid27083059">{{cite journal |vauthors=Garcia GJ, Hariri BM, Patel RG, Rhee JS |title=The relationship between nasal resistance to airflow and the airspace minimal cross-sectional area |journal=J Biomech |volume=49 |issue=9 |pages=1670–8 |year=2016 |pmid=27083059 |doi=10.1016/j.jbiomech.2016.03.051 |url=}}</ref>
Nasal [[endoscopy]] and anterior rhinoscopy can be done in the case of rhinosinusitis to evaluate for nasal anatomy, [[nasal polyps]] and the paranasal [[sinuses]]. [[Endoscopy]] can be done as part of the [[Functional Endoscopic Sinus Surgery|functional endoscopic sinus surgery]] (FESS), which is used as a treatment in the case of [[chronic]] rhinosinusitis and [[nasal polyps]].<ref name="pmid27340637">{{cite journal |vauthors=K Maru Y, Gupta Y |title=Nasal Endoscopy Versus Other Diagnostic Tools in Sinonasal Diseases |journal=Indian J Otolaryngol Head Neck Surg |volume=68 |issue=2 |pages=202–6 |year=2016 |pmid=27340637 |doi=10.1007/s12070-014-0762-y |url=}}</ref><ref name="pmid27083059">{{cite journal |vauthors=Garcia GJ, Hariri BM, Patel RG, Rhee JS |title=The relationship between nasal resistance to airflow and the airspace minimal cross-sectional area |journal=J Biomech |volume=49 |issue=9 |pages=1670–8 |year=2016 |pmid=27083059 |doi=10.1016/j.jbiomech.2016.03.051 |url=}}</ref>
 
==Medical Therapy==
==Medical Therapy==
Supportive therapy is the mainstay of treatment for both cases of acute and chronic rhinosinusitis. Antibiotics can be added in select cases of acute, as well as chronic rhinosinusitis.
Supportive therapy is the mainstay of treatment for both cases of [[acute]] and [[chronic]] rhinosinusitis. [[Antibiotics]] can be added in select cases of [[acute]], as well as [[chronic]] rhinosinusitis.
==Surgery==
==Surgery==
Functional endoscopic sinus surgery (FESS) is reserved for cases of chronic rhinosinusitis not responding to medical therapy.
Functional endoscopic sinus surgery (FESS) is reserved for cases of [[chronic]] rhinosinusitis not responding to medical therapy.
==Primary Prevention==
==Primary Prevention==
There are no clear guidelines on how to prevent the occurrence of rhinosinusitis.<ref name="pmid25379119">{{cite journal |vauthors=Bachert C, Pawankar R, Zhang L, Bunnag C, Fokkens WJ, Hamilos DL, Jirapongsananuruk O, Kern R, Meltzer EO, Mullol J, Naclerio R, Pilan R, Rhee CS, Suzaki H, Voegels R, Blaiss M |title=ICON: chronic rhinosinusitis |journal=World Allergy Organ J |volume=7 |issue=1 |pages=25 |year=2014 |pmid=25379119 |pmc=4213581 |doi=10.1186/1939-4551-7-25 |url=}}</ref>
There are no clear guidelines on how to prevent the occurrence of rhinosinusitis.<ref name="pmid25379119">{{cite journal |vauthors=Bachert C, Pawankar R, Zhang L, Bunnag C, Fokkens WJ, Hamilos DL, Jirapongsananuruk O, Kern R, Meltzer EO, Mullol J, Naclerio R, Pilan R, Rhee CS, Suzaki H, Voegels R, Blaiss M |title=ICON: chronic rhinosinusitis |journal=World Allergy Organ J |volume=7 |issue=1 |pages=25 |year=2014 |pmid=25379119 |pmc=4213581 |doi=10.1186/1939-4551-7-25 |url=}}</ref>
==Secondary Prevention==
==Secondary Prevention==
Secondary prevention is mostly aimed at preventing the exacerbation of chronic rhinosinusitis or another episode of acute recurrent sinusitis. Methods such as abstinence from smoking, using saline nasal irrigation, and treatment of the underlying cause can be used to promote healthy sinuses. <ref name="AAFP"> American Academy of Family Physicians http://www.aafp.org/afp/2007/1201/p1718.html. Accessed on Oct. 4, 2016.</ref>


==References==  
==References==  
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[[Category:Otolaryngology]]
[[Category:Emergency mdicine]]
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[[Category:Infectious disease]]
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[[Category:Immunology]]
[[Category:Otolaryngology]]

Latest revision as of 00:01, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

Rhinosinusitis is the inflammation of the nasal mucosa and paranasal sinuses. The terms sinusitis and rhinosinusitis are used interchangeably, although rhinosinusitis is preferred because inflammation of the paranasal sinuses rarely ever occurs without concurrent inflammation of the nasal mucosa. There are 4 pairs of sinus cavities, named for the skull bones they are located in: maxillary, ethmoid, frontal and sphenoidal. The cause of rhinosinusitis is mostly infectious, although it can be associated with other medical conditions such as allergies. The diagnosis is primarily clinical and imaging and other diagnostic studies are not necessary for diagnosis. A CT or MRI is indicated when rhinosinusitis is complicated by extension of the infection to surrounding structures, such as the orbit and brain. Rhinosinusitis is a self-limiting disease and treatment is supportive, in order to alleviate the respiratory symptoms and pain. Antibiotics may be indicated in select cases of acute bacterial and chronic rhinosinusitis.

Historical Perspective

  • Between 3700 and 1500 BC, the paranasal sinuses were first identified by the ancient Egyptians. The ancient Egyptians are considered to have been the first in discovering sinus surgery; when mummifying a human body, they would remove the brain through the nasal cavity.[1]
  • Hippocrates later described the process of producing voice as "air passing through empty cavities," which referred to the paranasal sinuses. He also documented in his writings about nasal polyps and how to remove them.[1]
  • In 1489, Leonardo Da Vinci was the first to illustrate the maxillary sinuses and their relationship with the teeth of the upper jaw. [2]
  • In 1905, the first paper in literature was found on suppurative frontal sinusitis.[3]

Classification

Rhinosinusitis can be classified based on the location of sinus involved into maxillary, frontal, ethmoidal, sphenoidal or pansinusitis.[4][5][6]. It can also be classified according to the duration of the disease or etiology.[7][8]

Pathophysiology

The pathophysiology for both acute and chronic rhinosinusitis involves blockage of the nasal sinuses and inflammation of the nasal sinuses. However, biofilms play a role in the pathogenesis of chronic rhinosinusitis. There are many associated conditions with rhinosinusitis, but most notably are those related to allergy and immunodeficiency.

Causes

The causes of rhinosinusitis can be divided according to the infectious group that causes it into: bacterial, viral and fungal.

Differential Diagnosis

Rhinosinusitis must be differentiated from other diseases that may present with a headache and/or respiratory symptoms.

Epidemiology and Demographics

The incidence of acute rhinosinusitis and prevalence of chronic rhinosinusitis have a wide range, depending on the setting.

Risk Factors

Anatomical abnormalities of the nasal cavity, immunodeficiency and other diseases are all risk factors for the development of rhinosinusitis.

Screening

There are no recommendations for screening for rhinosinusitis.[9]

Natural History, Complications and Prognosis

Acute rhinosinusitis is a self-limiting disease. However, rarely acute and chronic rhinosinusitis can be complicated by extension of the infection to the surrounding structures, such as the eyes and brain.

History and Symptoms

Rhinosinusitis can present with a wide range of constitutional and respiratory symptoms.

Physical Examination

Examination of the nose with a speculum or otoscope may reveal mucosal edema, narrowing of the middle meatus, purulent rhinorrhea and other findings.

Laboratory Findings

There are several lab findings that can be done when suspecting rhinosinusitis, but these findings are nonspecific.

X-Ray

A plain x-ray of the sinuses has no role in the workup of rhinosinusitis. It may show a fluid level in the sinuses, but a plain x-ray is associated with a high negative and high positive rate for rhinosinusitis.[10][11]

CT

Although not routinely indicated for suspected cases of rhinosinusitis and findings are highly nonspecific, CT scan is the imaging modality of choice in cases of chronic or complicated rhinosinusitis. Positive CT scan findings are not essential for diagnosis, but negative CT scan findings rules out rhinosinusitis. Findings include mucosal thickening and narrowing of the osteomeatal sinuses.[11][12][13][7]

Other Imaging Findings

MRI is an excellent alternative to CT scan in detecting orbital and intracranial complications of rhinosinusitis.[14][15]

Other Diagnostic Studies

Nasal endoscopy and anterior rhinoscopy can be done in the case of rhinosinusitis to evaluate for nasal anatomy, nasal polyps and the paranasal sinuses. Endoscopy can be done as part of the functional endoscopic sinus surgery (FESS), which is used as a treatment in the case of chronic rhinosinusitis and nasal polyps.[16][17]

Medical Therapy

Supportive therapy is the mainstay of treatment for both cases of acute and chronic rhinosinusitis. Antibiotics can be added in select cases of acute, as well as chronic rhinosinusitis.

Surgery

Functional endoscopic sinus surgery (FESS) is reserved for cases of chronic rhinosinusitis not responding to medical therapy.

Primary Prevention

There are no clear guidelines on how to prevent the occurrence of rhinosinusitis.[18]

Secondary Prevention

Secondary prevention is mostly aimed at preventing the exacerbation of chronic rhinosinusitis or another episode of acute recurrent sinusitis. Methods such as abstinence from smoking, using saline nasal irrigation, and treatment of the underlying cause can be used to promote healthy sinuses. [19]

References

  1. 1.0 1.1 Mavrodi A, Paraskevas G (2013). "Evolution of the paranasal sinuses' anatomy through the ages". Anat Cell Biol. 46 (4): 235–8. doi:10.5115/acb.2013.46.4.235. PMC 3875840. PMID 24386595.
  2. The Drawings of Leonardo http://www.drawingsofleonardo.org. Accessed on Oct. 3rd, 2016.
  3. Milligan W (1905). "SUPPURATIVE FRONTAL SINUSITIS: ITS SURGICAL TREATMENT, BASED ON AN ANALYSIS OF FORTY CASES". Br Med J. 1 (2300): 171–4. PMC 2318988. PMID 20761892.
  4. World Health Organization International Classification of Disease (2016) http://apps.who.int/classifications/icd10/browse/2016/en#/J01 Accessed on September 22, 2016.
  5. American Academy of Allergy Asthma and Immunology (2014) https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20Management/finances-coding/sinus-disease-codes-ICD10.pdf Accessed on September 22, 2016.
  6. Mandell, Gerald; Douglas, R.Gordon; Bennett, John (1985). Principles and Practice of Infectious Disease. USA: A Wiley Medical Publication. p. 370. ISBN 0471876437.
  7. 7.0 7.1 Rosenfeld RM (2016). "CLINICAL PRACTICE. Acute Sinusitis in Adults". N Engl J Med. 375 (10): 962–70. doi:10.1056/NEJMcp1601749. PMID 27602668.
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