Rhabdomyosarcoma laboratory findings: Difference between revisions

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{{Rhabdomyosarcoma}}
{{Rhabdomyosarcoma}}
{{CMG}}
{{CMG}};{{AE}} {{S.M}}
 
==Overview==
The essential [[laboratory]] tests for [[patients]] with [[rhabdomyosarcoma]] are evaluation of [[CBC]], [[liver function tests]], [[renal function tests]], [[blood]] [[Electrolyte|electrolytes]], and [[coagulation]] studies.
 
== Laboratory Findings==
* The essential [[laboratory]] tests for [[patients]] with [[rhabdomyosarcoma]] are:<ref name="pmid10466447">{{cite journal| author=Fiegl M, Weltermann A, Stindl R, Fonatsch C, Lechner K, Gisslinger H| title=Massive disseminated intravascular coagulation and hyperfibrinolysis in alveolar rhabdomyosarcoma: case report and review of the literature. | journal=Ann Hematol | year= 1999 | volume= 78 | issue= 7 | pages= 335-8 | pmid=10466447 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10466447  }} </ref><ref name="pmid9703006">{{cite journal| author=Kawasaki H, Takayama J, Nagasaki K, Yamaguchi K, Ohira M| title=Hypercalcemia in children with rhabdomyosarcoma. | journal=J Pediatr Hematol Oncol | year= 1998 | volume= 20 | issue= 4 | pages= 327-9 | pmid=9703006 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9703006  }} </ref>
** [[CBC]]:
*** It may result into [[pancytopenia]] and [[anemia]] due to [[bone]] involvement.
** [[Liver function test]] ( [[LFT]]):
*** [[LFT]] should be evaluated before [[chemotherapy]] and for assessment of [[liver]] [[metastasis]].
** [[Renal function tests|Renal function test]]:
*** [[BUN]] and [[creatinine]] levels should be evaluated before [[chemotherapy]].
** Blood [[Electrolyte|electrolytes]] such as [[sodium]], [[potassium]], [[chlorine]], [[calcium]], [[Phosphorous acid|phosphorous]], and [[magnesium]]:
*** [[Hypercalcemia]] may occur.
*** These tests should be evaluated before [[chemotherapy]].
** [[Coagulation]] studies:
*** [[Disseminated intravascular coagulation]] may occur.


==Laboratory Findings==
When rhabdomyosarcoma is suspected, tests will be run for blood, muscle, and marrow.


Diagnosis of rhabdomyosarcoma depends on recognition of [[differentiation]] toward skeletal muscle cells.  The protein ''myo D1'' is a protein normally found in developing skeletal muscle cells which disappears after the muscle matures and becomes innervated by a [[nerve]].  Thus, myo D1 is not found in normal skeletal muscle and serves as a useful immunohistochemical marker of rhabdomyosarcoma.


==References==
==References==
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Orthopedics]]

Latest revision as of 16:56, 8 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]

Overview

The essential laboratory tests for patients with rhabdomyosarcoma are evaluation of CBC, liver function tests, renal function tests, blood electrolytes, and coagulation studies.

Laboratory Findings


References

  1. Fiegl M, Weltermann A, Stindl R, Fonatsch C, Lechner K, Gisslinger H (1999). "Massive disseminated intravascular coagulation and hyperfibrinolysis in alveolar rhabdomyosarcoma: case report and review of the literature". Ann Hematol. 78 (7): 335–8. PMID 10466447.
  2. Kawasaki H, Takayama J, Nagasaki K, Yamaguchi K, Ohira M (1998). "Hypercalcemia in children with rhabdomyosarcoma". J Pediatr Hematol Oncol. 20 (4): 327–9. PMID 9703006.

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