Retinoblastoma staging: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Retinoblastoma}}
{{Retinoblastoma}}
{{CMG}},{{AS}}{{JC}}
{{CMG}}{{AE}}{{Simrat}}
==Overview==
==Overview==
Retinoblastoma may be classified into several subtypes based on the International Retinoblastoma Staging System (IRSS).
Retinoblastoma may be classified into several subgroups based on the International Retinoblastoma Staging System (IRSS).


==Staging==
==Staging==
A number of systems have been devised to stage retinoblastoma, with various end-points, and multiple systems are often used concurrently.  
The International Classification for Intraocular Retinoblastoma, based upon the Philadelphia and Murphree systems,<ref name="pmid10388023">{{cite journal| author=Pratt CB, Fontanesi J, Lu X, Parham DM, Elfervig J, Meyer D| title=Proposal for a New Staging Scheme for Intraocular and Extraocular Retinoblastoma Based on an Analysis of 103 Globes. | journal=Oncologist | year= 1997 | volume= 2 | issue= 1 | pages= 1-5 | pmid=10388023 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10388023  }} </ref> <ref name="pmid15136321">{{cite journal| author=Shields CL, Mashayekhi A, Demirci H, Meadows AT, Shields JA| title=Practical approach to management of retinoblastoma. | journal=Arch Ophthalmol | year= 2004 | volume= 122 | issue= 5 | pages= 729-35 | pmid=15136321 | doi=10.1001/archopht.122.5.729 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15136321  }} </ref><ref name="pmid15763190">{{cite journal| author=Linn Murphree A| title=Intraocular retinoblastoma: the case for a new group classification. | journal=Ophthalmol Clin North Am | year= 2005 | volume= 18 | issue= 1 | pages= 41-53, viii | pmid=15763190 | doi=10.1016/j.ohc.2004.11.003 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15763190  }} </ref> is currently the classification being used by the Children's Oncology Group in multicenter treatment protocols <ref name="pmid16996605">{{cite journal| author=Shields CL, Mashayekhi A, Au AK, Czyz C, Leahey A, Meadows AT et al.| title=The International Classification of Retinoblastoma predicts chemoreduction success. | journal=Ophthalmology | year= 2006 | volume= 113 | issue= 12 | pages= 2276-80 | pmid=16996605 | doi=10.1016/j.ophtha.2006.06.018 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16996605  }} </ref><ref name="pmid15763190">{{cite journal| author=Linn Murphree A| title=Intraocular retinoblastoma: the case for a new group classification. | journal=Ophthalmol Clin North Am | year= 2005 | volume= 18 | issue= 1 | pages= 41-53, viii | pmid=15763190 | doi=10.1016/j.ohc.2004.11.003 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15763190  }} </ref>. The goal of International Classification of Retinoblastoma (ICRB) is to reflect the likelihood of ocular survival based on modern treatment techniques such as chemotherapy and focal therapy. The International Classification of Retinoblastoma (ICRB) was developed to better predict those with intraocular retinoblastoma who are likely to be cured without the need for external-beam radiation treatment or enucleation.  
The Reese Ellsworth classification is assessed with fundoscopy and aims at predicting the chance of preserving the eye with external beam radiotherapy. .
More relevant to radiology practice is the International retinoblastoma classification which predicts overall survival
===The International Retinoblastoma Staging System (IRSS)===
===The International Retinoblastoma Staging System (IRSS)===
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center

Revision as of 16:30, 13 October 2015

Retinoblastoma Microchapters

Home

Patient Information

Overview

Historical perspective

Classification

Pathophysiology

Causes

Differentiating Retinoblastoma from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural history, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

History & Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Retinoblastoma staging On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Retinoblastoma staging

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Retinoblastoma staging

CDC on Retinoblastoma staging

Retinoblastoma staging in the news

Blogs on Retinoblastoma staging

Directions to Hospitals Treating Retinoblastoma

Risk calculators and risk factors for Retinoblastoma staging

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Retinoblastoma may be classified into several subgroups based on the International Retinoblastoma Staging System (IRSS).

Staging

The International Classification for Intraocular Retinoblastoma, based upon the Philadelphia and Murphree systems,[1] [2][3] is currently the classification being used by the Children's Oncology Group in multicenter treatment protocols [4][3]. The goal of International Classification of Retinoblastoma (ICRB) is to reflect the likelihood of ocular survival based on modern treatment techniques such as chemotherapy and focal therapy. The International Classification of Retinoblastoma (ICRB) was developed to better predict those with intraocular retinoblastoma who are likely to be cured without the need for external-beam radiation treatment or enucleation.

The International Retinoblastoma Staging System (IRSS)

Stage Features
Stage 0
  • Patients treated conservatively
Stage I
  • eye enucleated, completely resected histologically
Stage II
  • eye enucleated, microscopic residual tumor
Stage III
Stage III A
Stage III B
  • regional extension
  • overt orbital disease
  • preauricular or cervical lymph node extension
Stage IV
Stage IV A




Stage IV B


  • Metastasis
  • haematogeneous metastasis without CNS involvement
  • single lesion
  • multiple lesions
  • preauricular or cervical lymph node extension
  • CNS metastatic involvement
  • prechiasmatic lesion
  • CNS mass
  • leptomeningeal disease

References

  1. Pratt CB, Fontanesi J, Lu X, Parham DM, Elfervig J, Meyer D (1997). "Proposal for a New Staging Scheme for Intraocular and Extraocular Retinoblastoma Based on an Analysis of 103 Globes". Oncologist. 2 (1): 1–5. PMID 10388023.
  2. Shields CL, Mashayekhi A, Demirci H, Meadows AT, Shields JA (2004). "Practical approach to management of retinoblastoma". Arch Ophthalmol. 122 (5): 729–35. doi:10.1001/archopht.122.5.729. PMID 15136321.
  3. 3.0 3.1 Linn Murphree A (2005). "Intraocular retinoblastoma: the case for a new group classification". Ophthalmol Clin North Am. 18 (1): 41–53, viii. doi:10.1016/j.ohc.2004.11.003. PMID 15763190.
  4. Shields CL, Mashayekhi A, Au AK, Czyz C, Leahey A, Meadows AT; et al. (2006). "The International Classification of Retinoblastoma predicts chemoreduction success". Ophthalmology. 113 (12): 2276–80. doi:10.1016/j.ophtha.2006.06.018. PMID 16996605.

Template:WH Template:WS

See also


Template:Nervous tissue tumors