Renal agenesis history and symptoms: Difference between revisions
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{{Renal agenesis}} | {{Renal agenesis}} | ||
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== Overview == | |||
Since patients with unilateral renal agenesis (URA) have an increased risk for [[proteinuria]], [[hypertension]], and [[renal insufficiency]], checking for symptoms of these complications should be considered. Checking for other contralateral [[Congenital disorder|congenital]] [[anomaly]] of [[kidney]] or [[Urinary system|urinary tract]] (CAKUT) such as [[Vesicoureteral reflux|VUR (vesicoureteral reflux)]] and PUJO (pelviureteric junction obstruction), extra-renal [[Anomaly|anomalies]] in different organs (such as [[Heart|cardiac]], [[lung]], [[Gastrointestinal tract|gastrointestinal]], [[Sex organ|genital]], [[skeleton]], and [[Vertebra|vertebral]]) , and associated syndromes and sequences (such as [[VACTERL association|VACTERL]], [[CHARGE syndrome|CHARGE]] and [[Edwards syndrome|Trisomy 18]]) should be considered when URA is diagnosed. | |||
== History == | |||
Maternal history during pregnancy for the following may be important in unilateral renal disease (URA):<ref name="pmid16956352">{{cite journal| author=Woolf AS, Hillman KA| title=Unilateral renal agenesis and the congenital solitary functioning kidney: developmental, genetic and clinical perspectives. | journal=BJU Int | year= 2007 | volume= 99 | issue= 1 | pages= 17-21 | pmid=16956352 | doi=10.1111/j.1464-410X.2006.06504.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16956352 }} </ref> | |||
* Uncontrolled [[diabetes]] | |||
* Treatment for [[hypertension]] | |||
The following may be important to check in the [[family history]] of patients with URA:<ref name="pmid30734167">{{cite journal| author=Xu Q, Wu H, Zhou L, Xie J, Zhang W, Yu H | display-authors=etal| title=The clinical characteristics of Chinese patients with unilateral renal agenesis. | journal=Clin Exp Nephrol | year= 2019 | volume= 23 | issue= 6 | pages= 792-798 | pmid=30734167 | doi=10.1007/s10157-019-01704-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30734167 }} </ref> | |||
* URA | |||
* CAKUT (congenital [[Anomaly|anomalies]] of the [[kidney]] and [[Urinary system|urinary tract]]) | |||
* [[End stage renal disease|End stage renal disease (ESRD)]] | |||
* [[Consanguinity]] | |||
== Symptoms == | |||
Since patients with unilateral renal agenesis (URA) have an increased risk for [[proteinuria]], [[hypertension]], and [[renal insufficiency]], checking for symptoms of these complications should be considered.<ref name="pmid30734167" /> | |||
Checking for other contralateral [[Congenital disorder|congenital]] [[anomaly]] of [[kidney]] or [[Urinary system|urinary tract]] (CAKUT) such as [[Vesicoureteral reflux|VUR (vesicoureteral reflux)]] and PUJO (pelviureteric junction obstruction), extra-renal [[Anomaly|anomalies]] in different organs (such as [[Heart|cardiac]], [[lung]], [[Gastrointestinal tract|gastrointestinal]], [[Sex organ|genital]], [[skeleton]], and [[Vertebra|vertebral]]) , and associated syndromes and sequences (such as [[VACTERL association|VACTERL]], [[CHARGE syndrome|CHARGE]] and [[Edwards syndrome|Trisomy 18]]) should be considered when URA is diagnosed.<ref name="pmid28722320">{{cite journal| author=Laurichesse Delmas H, Kohler M, Doray B, Lémery D, Francannet C, Quistrebert J | display-authors=etal| title=Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries. | journal=Birth Defects Res | year= 2017 | volume= 109 | issue= 15 | pages= 1204-1211 | pmid=28722320 | doi=10.1002/bdr2.1065 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28722320 }} </ref><ref name="pmid23449343">{{cite journal| author=Westland R, Schreuder MF, Ket JC, van Wijk JA| title=Unilateral renal agenesis: a systematic review on associated anomalies and renal injury. | journal=Nephrol Dial Transplant | year= 2013 | volume= 28 | issue= 7 | pages= 1844-55 | pmid=23449343 | doi=10.1093/ndt/gft012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23449343 }} </ref> | |||
==References== | ==References== | ||
Latest revision as of 14:29, 1 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
Since patients with unilateral renal agenesis (URA) have an increased risk for proteinuria, hypertension, and renal insufficiency, checking for symptoms of these complications should be considered. Checking for other contralateral congenital anomaly of kidney or urinary tract (CAKUT) such as VUR (vesicoureteral reflux) and PUJO (pelviureteric junction obstruction), extra-renal anomalies in different organs (such as cardiac, lung, gastrointestinal, genital, skeleton, and vertebral) , and associated syndromes and sequences (such as VACTERL, CHARGE and Trisomy 18) should be considered when URA is diagnosed.
History
Maternal history during pregnancy for the following may be important in unilateral renal disease (URA):[1]
- Uncontrolled diabetes
- Treatment for hypertension
The following may be important to check in the family history of patients with URA:[2]
- URA
- CAKUT (congenital anomalies of the kidney and urinary tract)
- End stage renal disease (ESRD)
- Consanguinity
Symptoms
Since patients with unilateral renal agenesis (URA) have an increased risk for proteinuria, hypertension, and renal insufficiency, checking for symptoms of these complications should be considered.[2]
Checking for other contralateral congenital anomaly of kidney or urinary tract (CAKUT) such as VUR (vesicoureteral reflux) and PUJO (pelviureteric junction obstruction), extra-renal anomalies in different organs (such as cardiac, lung, gastrointestinal, genital, skeleton, and vertebral) , and associated syndromes and sequences (such as VACTERL, CHARGE and Trisomy 18) should be considered when URA is diagnosed.[3][4]
References
- ↑ Woolf AS, Hillman KA (2007). "Unilateral renal agenesis and the congenital solitary functioning kidney: developmental, genetic and clinical perspectives". BJU Int. 99 (1): 17–21. doi:10.1111/j.1464-410X.2006.06504.x. PMID 16956352.
- ↑ 2.0 2.1 Xu Q, Wu H, Zhou L, Xie J, Zhang W, Yu H; et al. (2019). "The clinical characteristics of Chinese patients with unilateral renal agenesis". Clin Exp Nephrol. 23 (6): 792–798. doi:10.1007/s10157-019-01704-x. PMID 30734167.
- ↑ Laurichesse Delmas H, Kohler M, Doray B, Lémery D, Francannet C, Quistrebert J; et al. (2017). "Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries". Birth Defects Res. 109 (15): 1204–1211. doi:10.1002/bdr2.1065. PMID 28722320.
- ↑ Westland R, Schreuder MF, Ket JC, van Wijk JA (2013). "Unilateral renal agenesis: a systematic review on associated anomalies and renal injury". Nephrol Dial Transplant. 28 (7): 1844–55. doi:10.1093/ndt/gft012. PMID 23449343.