Receptor activity-modifying protein

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Receptor activity-modifying protein 1 (RAMP1)
Identifiers
SymbolRAMP1
Entrez10267
HUGO9843
OMIM605153
RefSeqNM_005855
UniProtO60894
Other data
LocusChr. 2 q36-37.1
Receptor activity-modifying protein 2 (RAMP2)
Identifiers
SymbolRAMP2
Entrez10266
HUGO9844
OMIM605154
RefSeqNM_005854
UniProtO60895
Other data
LocusChr. 17 q12-21.1
Receptor activity-modifying protein 1 (RAMP3)
Identifiers
SymbolRAMP3
Entrez10268
HUGO9845
OMIM605155
RefSeqNM_005856
UniProtO60896
Other data
LocusChr. 7 q13-p12

Receptor activity-modifying proteins (RAMPs) are a class of proteins which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP).[1] There are three distinct types of RAMPs, designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene.[2]

External links

References

  1. Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A (2006). "Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs". Ann N Y Acad Sci. 1070: 90–104. PMID 16888151.
  2. Young A (2005). "Amylin: Physiology and Pharmacology; Chapter 3: Receptor pharmacology". Advances in Pharmacology. 52: 47–65. PMID 16492540.