RNF128: Difference between revisions
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==Interactions== | ==Interactions== | ||
RNF128 has been shown to [[ | RNF128 has been shown to [[Protein–protein interaction|interact]] with [[CD154]]<ref name=pmid18641297>{{cite journal |last=Lineberry |first=Neil B |authorlink= |author2=Su Leon L |author3=Lin Jack T |author4=Coffey Greg P |author5=Seroogy Christine M |author6=Fathman C Garrison |date=Aug 2008 |title=Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy |journal=J. Immunol. |volume=181 |issue=3 |pages=1622–6 |publisher= |location = United States| issn = | pmid = 18641297 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2853377 | doi=10.4049/jimmunol.181.3.1622}}</ref> and [[OTUB1]].<ref name=pmid14661020>{{cite journal |last=Soares |first=Luis |authorlink= |author2=Seroogy Christine |author3=Skrenta Heidi |author4=Anandasabapathy Niroshana |author5=Lovelace Patricia |author6=Chung Chan D |author7=Engleman Edgar |author8=Fathman C Garrison |date=Jan 2004 |title=Two isoforms of otubain 1 regulate T cell anergy via GRAIL |journal=Nat. Immunol. |volume=5 |issue=1 |pages=45–54 |publisher= |location = United States| issn = 1529-2908| pmid = 14661020 |doi = 10.1038/ni1017 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | ||
==References== | ==References== | ||
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*{{cite journal |vauthors=Kostianovsky AM, Maier LM, Baecher-Allan C, etal |title=Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. |journal=J. Immunol. |volume=178 |issue= 10 |pages= 6158–63 |year= 2007 |pmid= 17475842 |doi= 10.4049/jimmunol.178.10.6158}} | *{{cite journal |vauthors=Kostianovsky AM, Maier LM, Baecher-Allan C, etal |title=Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. |journal=J. Immunol. |volume=178 |issue= 10 |pages= 6158–63 |year= 2007 |pmid= 17475842 |doi= 10.4049/jimmunol.178.10.6158}} | ||
*{{cite journal |vauthors=MacKenzie DA, Schartner J, Lin J, etal |title=GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. |journal=J. Biol. Chem. |volume=282 |issue= 13 |pages= 9696–702 |year= 2007 |pmid= 17259178 |doi= 10.1074/jbc.M604192200 }} | *{{cite journal |vauthors=MacKenzie DA, Schartner J, Lin J, etal |title=GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. |journal=J. Biol. Chem. |volume=282 |issue= 13 |pages= 9696–702 |year= 2007 |pmid= 17259178 |doi= 10.1074/jbc.M604192200 }} | ||
*{{cite journal |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }} | *{{cite journal |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |bibcode=2005Natur.434..325R }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal |vauthors=Soares L, Seroogy C, Skrenta H, etal |title=Two isoforms of otubain 1 regulate T cell anergy via GRAIL. |journal=Nat. Immunol. |volume=5 |issue= 1 |pages= 45–54 |year= 2004 |pmid= 14661020 |doi= 10.1038/ni1017 }} | *{{cite journal |vauthors=Soares L, Seroogy C, Skrenta H, etal |title=Two isoforms of otubain 1 regulate T cell anergy via GRAIL. |journal=Nat. Immunol. |volume=5 |issue= 1 |pages= 45–54 |year= 2004 |pmid= 14661020 |doi= 10.1038/ni1017 }} | ||
*{{cite journal |vauthors=Anandasabapathy N, Ford GS, Bloom D, etal |title=GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. |journal=Immunity |volume=18 |issue= 4 |pages= 535–47 |year= 2003 |pmid= 12705856 |doi=10.1016/S1074-7613(03)00084-0 }} | *{{cite journal |vauthors=Anandasabapathy N, Ford GS, Bloom D, etal |title=GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. |journal=Immunity |volume=18 |issue= 4 |pages= 535–47 |year= 2003 |pmid= 12705856 |doi=10.1016/S1074-7613(03)00084-0 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
Latest revision as of 01:48, 26 June 2018
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E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene.[1]
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]
Interactions
RNF128 has been shown to interact with CD154[2] and OTUB1.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: RNF128 ring finger protein 128".
- ↑ Lineberry, Neil B; Su Leon L; Lin Jack T; Coffey Greg P; Seroogy Christine M; Fathman C Garrison (Aug 2008). "Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy". J. Immunol. United States. 181 (3): 1622–6. doi:10.4049/jimmunol.181.3.1622. PMC 2853377. PMID 18641297.
- ↑ Soares, Luis; Seroogy Christine; Skrenta Heidi; Anandasabapathy Niroshana; Lovelace Patricia; Chung Chan D; Engleman Edgar; Fathman C Garrison (Jan 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nat. Immunol. United States. 5 (1): 45–54. doi:10.1038/ni1017. ISSN 1529-2908. PMID 14661020.
Further reading
- Kostianovsky AM, Maier LM, Baecher-Allan C, et al. (2007). "Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression". J. Immunol. 178 (10): 6158–63. doi:10.4049/jimmunol.178.10.6158. PMID 17475842.
- MacKenzie DA, Schartner J, Lin J, et al. (2007). "GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype". J. Biol. Chem. 282 (13): 9696–702. doi:10.1074/jbc.M604192200. PMID 17259178.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Soares L, Seroogy C, Skrenta H, et al. (2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nat. Immunol. 5 (1): 45–54. doi:10.1038/ni1017. PMID 14661020.
- Anandasabapathy N, Ford GS, Bloom D, et al. (2003). "GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells". Immunity. 18 (4): 535–47. doi:10.1016/S1074-7613(03)00084-0. PMID 12705856.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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