RNF128

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene.[1]

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]

Interactions

RNF128 has been shown to interact with CD154[2] and OTUB1.[3]

References

  1. 1.0 1.1 "Entrez Gene: RNF128 ring finger protein 128".
  2. Lineberry, Neil B; Su Leon L; Lin Jack T; Coffey Greg P; Seroogy Christine M; Fathman C Garrison (Aug 2008). "Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy". J. Immunol. United States. 181 (3): 1622–6. doi:10.4049/jimmunol.181.3.1622. PMC 2853377. PMID 18641297.
  3. Soares, Luis; Seroogy Christine; Skrenta Heidi; Anandasabapathy Niroshana; Lovelace Patricia; Chung Chan D; Engleman Edgar; Fathman C Garrison (Jan 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nat. Immunol. United States. 5 (1): 45–54. doi:10.1038/ni1017. ISSN 1529-2908. PMID 14661020.

Further reading