Polymyositis and dermatomyositis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. | The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. | ||
==Pathophysiology== | ==Pathophysiology== | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
* | *Polymyositis is caused by [[inflammation]] and [[degeneration]] of the [[Muscle|muscles]]. Dermatomyositis is caused by skin [[inflammation]]. | ||
*The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. However, it is understood that polymyositis and dermatomyositis are the result of autoimmune attack but triggering factors of are not well-known. | |||
* | |||
*The | |||
* | |||
====Antisynthetase syndrome==== | ====Antisynthetase syndrome==== | ||
====Amyopathic dermatomyositis==== | ====Amyopathic dermatomyositis==== | ||
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==Associated Conditions== | ==Associated Conditions== | ||
Different conditions associated with polymyositis and dermatomyositis include: | Different conditions associated with polymyositis and dermatomyositis include: | ||
*Interstitial lung disease | *[[Interstitial lung disease]] | ||
*Conduction abnormalities and arrhythmia | *[[Conduction disorders|Conduction abnormalities]] and [[Cardiac arrhythmia|arrhythmia]] | ||
*Myocardial infarction | *[[Myocardial infarction]] | ||
*Malignancy like: | *[[Cancer|Malignancy]] like: | ||
*Other connective tissue diseases like | *Other [[Connective tissue disease|connective tissue diseases]] like | ||
**Scleroderma | **[[Scleroderma]] | ||
**SLE | **[[SLE]] | ||
**Mixed connective tissue disease | **[[Mixed connective tissue disease]] | ||
**Rheumatoid arthritis | **[[Rheumatoid arthritis]] | ||
**Sjögren's syndrome | **[[Sjögren's syndrome]] | ||
==Gross Pathology== | ==Gross Pathology== | ||
*On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. | *On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. | ||
Revision as of 19:59, 4 April 2018
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Polymyositis and dermatomyositis Microchapters |
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Differentiating Polymyositis and dermatomyositis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
The exact pathogenesis of polymyositis and dermatomyositis is not fully understood.
Pathophysiology
Pathogenesis
- Polymyositis is caused by inflammation and degeneration of the muscles. Dermatomyositis is caused by skin inflammation.
- The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. However, it is understood that polymyositis and dermatomyositis are the result of autoimmune attack but triggering factors of are not well-known.
Antisynthetase syndrome
Amyopathic dermatomyositis
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Different conditions associated with polymyositis and dermatomyositis include:
- Interstitial lung disease
- Conduction abnormalities and arrhythmia
- Myocardial infarction
- Malignancy like:
- Other connective tissue diseases like
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].