Polymyositis and dermatomyositis pathophysiology: Difference between revisions
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*Polymyositis is caused by [[inflammation]] and [[degeneration]] of the [[Muscle|muscles]]. Dermatomyositis is caused by skin [[inflammation]]. | *Polymyositis is caused by [[inflammation]] and [[degeneration]] of the [[Muscle|muscles]]. Dermatomyositis is caused by skin [[inflammation]]. | ||
*The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. However, it is understood that polymyositis and dermatomyositis are the result of autoimmune attack but triggering factors of are not well-known. | *The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. However, it is understood that polymyositis and dermatomyositis are the result of autoimmune attack but triggering factors of are not well-known. | ||
*Viral infection might be a trigger for immune system to attack muscle fibers and other tissues. | |||
* | * | ||
====Antisynthetase syndrome==== | ====Antisynthetase syndrome==== | ||
Revision as of 20:06, 4 April 2018
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Polymyositis and dermatomyositis Microchapters |
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Differentiating Polymyositis and dermatomyositis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Overview
The exact pathogenesis of polymyositis and dermatomyositis is not fully understood.
Pathophysiology
Pathogenesis
- Polymyositis is caused by inflammation and degeneration of the muscles. Dermatomyositis is caused by skin inflammation.
- The exact pathogenesis of polymyositis and dermatomyositis is not fully understood. However, it is understood that polymyositis and dermatomyositis are the result of autoimmune attack but triggering factors of are not well-known.
- Viral infection might be a trigger for immune system to attack muscle fibers and other tissues.
Antisynthetase syndrome
Amyopathic dermatomyositis
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Different conditions associated with polymyositis and dermatomyositis include:
- Interstitial lung disease
- Conduction abnormalities and arrhythmia
- Myocardial infarction
- Malignancy like:
- Other connective tissue diseases like
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].